(39 nodes) Pituitary gland development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_002107	GS homeobox 1. (112 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Aldh1a2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (460 aa)
	I79_025355	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (325 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	Tcf7l2	Transcription factor 7-like 1. (73 aa)
	Pitx2	Homeobox protein. (322 aa)
	I79_022078	Homeobox protein Nkx-2.1. (190 aa)
	I79_021679	POU domain protein. (218 aa)
	Rbpj	Recombining binding protein suppressor of hairless-like protein. (486 aa)
	I79_020783	Transcription factor 7-like 2. (451 aa)
	Lhx3	LIM/homeobox protein Lhx3. (403 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Adcyap1	Pituitary adenylate cyclase-activating polypeptide-like protein. (176 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Gli1	Zinc finger protein GLI1. (1104 aa)
	I79_014474	Cyclic AMP-responsive element-binding protein 1. (325 aa)
	Cdh1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	I79_010864	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (372 aa)
	Kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	Gata2	Endothelial transcription factor GATA-2. (480 aa)
	I79_008831	T-box transcription factor TBX19. (250 aa)
	Srd5a1	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_006180	Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (627 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	I79_004403	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (187 aa)
	Drd2	D(2) dopamine receptor. (274 aa)
	Isl1	Insulin gene enhancer protein ISL-1. (257 aa)
	Nog	Noggin. (117 aa)
	Gli2	Zinc finger protein GLI2. (1547 aa)
	I79_003741	Dual oxidase 2. (1367 aa)
	Pax6	Paired box protein Pax-6. (544 aa)
	I79_002659	High mobility group protein HMGI-C. (103 aa)
	Ghrh	Somatoliberin. (102 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcyap1	Ghrh	G3I5A7	G3GXX5	Pituitary adenylate cyclase-activating polypeptide-like protein.	Somatoliberin.	0.657
Adcyap1	I79_010864	G3I5A7	G3HJL6	Pituitary adenylate cyclase-activating polypeptide-like protein.	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.	0.813
Drd2	I79_004403	G3H2I9	G3H2J0	D(2) dopamine receptor.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.926
Drd2	I79_025355	G3H2I9	G3IN43	D(2) dopamine receptor.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.958
Gata2	I79_006254	G3HIC9	G3H7C4	Endothelial transcription factor GATA-2.	Bone morphogenetic protein 4.	0.434
Gata2	Isl1	G3HIC9	G3H207	Endothelial transcription factor GATA-2.	Insulin gene enhancer protein ISL-1.	0.423
Gata2	Lhx3	G3HIC9	G3I6Y3	Endothelial transcription factor GATA-2.	LIM/homeobox protein Lhx3.	0.429
Ghrh	Adcyap1	G3GXX5	G3I5A7	Somatoliberin.	Pituitary adenylate cyclase-activating polypeptide-like protein.	0.657
Ghrh	I79_010864	G3GXX5	G3HJL6	Somatoliberin.	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.	0.989
Gli1	Gli2	G3HW42	G3H142	Zinc finger protein GLI1.	Zinc finger protein GLI2.	0.985
Gli1	I79_006254	G3HW42	G3H7C4	Zinc finger protein GLI1.	Bone morphogenetic protein 4.	0.478
Gli1	I79_019149	G3HW42	G3I6M4	Zinc finger protein GLI1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
Gli1	Npm3	G3HW42	G3HXU8	Zinc finger protein GLI1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
Gli1	Pax6	G3HW42	G3GZA8	Zinc finger protein GLI1.	Paired box protein Pax-6.	0.505
Gli2	Gli1	G3H142	G3HW42	Zinc finger protein GLI2.	Zinc finger protein GLI1.	0.985
Gli2	Pax6	G3H142	G3GZA8	Zinc finger protein GLI2.	Paired box protein Pax-6.	0.423
I79_004403	Drd2	G3H2J0	G3H2I9	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	D(2) dopamine receptor.	0.926
I79_004403	I79_025355	G3H2J0	G3IN43	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.598
I79_006254	Gata2	G3H7C4	G3HIC9	Bone morphogenetic protein 4.	Endothelial transcription factor GATA-2.	0.434
I79_006254	Gli1	G3H7C4	G3HW42	Bone morphogenetic protein 4.	Zinc finger protein GLI1.	0.478