STRINGSTRING
Cul3 Cul3 Tet2 Tet2 Vdr Vdr I79_022023 I79_022023 Mki67 Mki67 I79_022741 I79_022741 Bsx Bsx Ar Ar Csf1 Csf1 I79_024048 I79_024048 Ptch1 Ptch1 Fgfr2 Fgfr2 I79_024314 I79_024314 I79_024593 I79_024593 Capn1 Capn1 I79_025170 I79_025170 I79_025176 I79_025176 I79_025388 I79_025388 I79_025795 I79_025795 I79_026146 I79_026146 I79_026151 I79_026151 I79_019663 I79_019663 I79_000092 I79_000092 Prox1 Prox1 I79_000300 I79_000300 Plxna1 Plxna1 Tp63 Tp63 Slc9a3r1 Slc9a3r1 I79_000973 I79_000973 I79_001073 I79_001073 Tbx3 Tbx3 Phb2 Phb2 Wnt5a Wnt5a I79_001487 I79_001487 Tgfbr2 Tgfbr2 Src Src Tgm2 Tgm2 I79_002693 I79_002693 Pax6 Pax6 Fgl1 Fgl1 Csmd1 Csmd1 I79_003312 I79_003312 Mmp2 Mmp2 I79_003741 I79_003741 Gli2 Gli2 Msx2 Msx2 Nog Nog I79_004031 I79_004031 Hoxd13 Hoxd13 Kdm5b Kdm5b Igfbp5 Igfbp5 I79_005358 I79_005358 Hoxb13 Hoxb13 Med1 Med1 Igf1 Igf1 I79_006225 I79_006225 I79_006254 I79_006254 I79_006442 I79_006442 I79_006650 I79_006650 Mst1 Mst1 Dag1 Dag1 Fem1b Fem1b I79_006792 I79_006792 Ncoa3 Ncoa3 I79_006881 I79_006881 Tbx2 Tbx2 Cav1 Cav1 I79_007641 I79_007641 Lrp6 Lrp6 Bmp7 Bmp7 Tfap2c Tfap2c Nfib Nfib I79_008319 I79_008319 Serpinb5 Serpinb5 I79_008941 I79_008941 Pml Pml Nr3c1 Nr3c1 Tgfb3 Tgfb3 Nrg3 Nrg3 Lama5 Lama5 Polb Polb Sfrp1 Sfrp1 Robo1 Robo1 I79_010159 I79_010159 I79_010279 I79_010279 Cdc42 Cdc42 Wnt4 Wnt4 I79_010613 I79_010613 I79_010622 I79_010622 Lrrc1 Lrrc1 I79_010651 I79_010651 Igf1r Igf1r Cdh1 Cdh1 Esrp2 Esrp2 I79_011943 I79_011943 Sema3c Sema3c Sema3a Sema3a Notch2 Notch2 Ddr1 Ddr1 CgPICR_001850 CgPICR_001850 Ctnnd1 Ctnnd1 Tnc Tnc Rarg Rarg Gli3 Gli3 Plxnd1 Plxnd1 I79_015109 I79_015109 Stat6 Stat6 I79_015223 I79_015223 I79_015381 I79_015381 Sostdc1 Sostdc1 Npm3 Npm3 Msn Msn Rps6ka1 Rps6ka1 Twsg1 Twsg1 Frs2 Frs2 Nrp1 Nrp1 Tnf Tnf Pdgfb Pdgfb I79_017861 I79_017861 I79_018023 I79_018023 Btrc Btrc Lrp5 Lrp5 Tgfa Tgfa I79_019149 I79_019149 I79_019286 I79_019286 Foxa1 Foxa1 Epha2 Epha2 Tgfb1 Tgfb1 Fgf7 Fgf7 Areg Areg
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cul3Cullin-3; Belongs to the cullin family. (746 aa)
Tet2Putative methylcytosine dioxygenase TET2. (273 aa)
VdrVitamin D3 receptor. (372 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
Mki67Antigen KI-67. (3232 aa)
I79_022741Putative methylcytosine dioxygenase TET2. (127 aa)
BsxBrain-specific homeobox protein-like. (89 aa)
ArAndrogen receptor. (517 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
I79_024048Paired box protein Pax-3. (324 aa)
Ptch1Protein patched-like 1. (1114 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_024314Paired box protein Pax-3. (301 aa)
I79_024593Uncharacterized protein. (194 aa)
Capn1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (740 aa)
I79_025170Slit-like 2 protein. (345 aa)
I79_025176Putative methylcytosine dioxygenase TET2. (113 aa)
I79_025388Putative methylcytosine dioxygenase TET2. (160 aa)
I79_025795Vitamin D3 receptor. (86 aa)
I79_026146ETS translocation variant 4. (95 aa)
I79_026151ETS translocation variant 4. (69 aa)
I79_01966325-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (216 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Prox1Prospero homeobox protein 1. (738 aa)
I79_000300Plexin-A1. (457 aa)
Plxna1Plexin-A1. (777 aa)
Tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
Slc9a3r1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (354 aa)
I79_000973Transcription factor SOX-10. (360 aa)
I79_001073C-C motif chemokine. (72 aa)
Tbx3T-box transcription factor TBX3. (709 aa)
Phb2Prohibitin-2. (396 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_001487Progesterone receptor. (741 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SrcTyrosine-protein kinase. (536 aa)
Tgm2Protein-glutamine gamma-glutamyltransferase 2. (686 aa)
I79_002693Netrin-1. (252 aa)
Pax6Paired box protein Pax-6. (544 aa)
Fgl1Fibrinogen-like protein 1. (314 aa)
Csmd1CUB and sushi domain-containing protein 1. (106 aa)
I79_003312CUB and sushi domain-containing protein 1. (3110 aa)
Mmp272 kDa type IV collagenase. (662 aa)
I79_003741Dual oxidase 2. (1367 aa)
Gli2Zinc finger protein GLI2. (1547 aa)
Msx2Homeobox protein MSX-2. (267 aa)
NogNoggin. (117 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
Hoxd13Homeobox protein Hox-D13. (204 aa)
Kdm5bLysine-specific demethylase 5B. (748 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
I79_005358Estrogen receptor beta. (58 aa)
Hoxb13Homeobox protein Hox-B13. (284 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_006225Sonic hedgehog protein. (226 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
I79_006442Relaxin receptor 1. (770 aa)
I79_006650Hepatocyte growth factor-like protein. (93 aa)
Mst1Hepatocyte growth factor-like protein. (88 aa)
Dag1Dystroglycan. (893 aa)
Fem1bProtein fem-1-like B. (469 aa)
I79_006792DUF1518 domain-containing protein. (200 aa)
Ncoa3Nuclear receptor coactivator 3. (1211 aa)
I79_006881CUB and sushi domain-containing protein 2. (3527 aa)
Tbx2T-box transcription factor TBX2. (234 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Tfap2cTranscription factor AP-2 gamma. (463 aa)
NfibNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
I79_008319Zinc finger protein 157. (381 aa)
Serpinb5Serpin B5; Belongs to the serpin family. (375 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
PmlPutative transcription factor PML. (540 aa)
Nr3c1Glucocorticoid receptor. (748 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
Nrg3Pro-neuregulin-3, membrane-bound isoform. (153 aa)
Lama5Laminin subunit alpha-5. (3735 aa)
PolbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Robo1Roundabout-like 1. (129 aa)
I79_010159Roundabout-like 1. (1362 aa)
I79_010279Epithelial splicing regulatory protein 1. (677 aa)
Cdc42Cell division control protein 42-like. (191 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
I79_010613Transcription factor AP-2 gamma. (236 aa)
I79_010622Leucine-rich repeat-containing protein 1. (119 aa)
Lrrc1Leucine-rich repeat-containing protein 1. (167 aa)
I79_010651Tumor necrosis factor receptor superfamily member EDAR. (403 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
Esrp2Epithelial splicing regulatory protein 2. (697 aa)
I79_011943Semaphorin-3C. (86 aa)
Sema3cSemaphorin-3C; Belongs to the semaphorin family. (493 aa)
Sema3aSemaphorin-3A-like protein; Belongs to the semaphorin family. (758 aa)
Notch2Neurogenic locus notch-like protein 2. (1521 aa)
Ddr1Epithelial discoidin domain-containing receptor 1 isoform 1. (910 aa)
CgPICR_001850Selenoprotein H. (100 aa)
Ctnnd1Catenin delta-1. (932 aa)
TncTenascin. (2202 aa)
RargRetinoic acid receptor gamma. (458 aa)
Gli3Zinc finger protein GLI3. (1582 aa)
Plxnd1Plexin-D1. (612 aa)
I79_015109Interleukin-6. (174 aa)
Stat6Signal transducer and activator of transcription. (844 aa)
I79_015223Neurogenic locus notch-like protein 2. (248 aa)
I79_015381Protein scribble-like. (789 aa)
Sostdc1Sclerostin domain-containing protein 1. (193 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
MsnMoesin. (293 aa)
Rps6ka1Ribosomal protein S6 kinase. (743 aa)
Twsg1Twisted gastrulation protein-like 1. (222 aa)
Frs2Fibroblast growth factor receptor substrate 2. (509 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (923 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
I79_017861Solute carrier family 12 member 2. (706 aa)
I79_018023Ectodysplasin-A; Belongs to the tumor necrosis factor family. (192 aa)
BtrcF-box/WD repeat-containing protein 1A. (488 aa)
Lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
TgfaProtransforming growth factor alpha. (211 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
I79_019286Androgen receptor. (295 aa)
Foxa1Hepatocyte nuclear factor 3-alpha. (434 aa)
Epha2Ephrin type-A receptor 2. (942 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
AregAmphiregulin. (230 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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