(103 nodes) Leukocyte chemotaxis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pikfyve	1-phosphatidylinositol-3-phosphate 5-kinase. (377 aa)
	Cxcl3	C-X-C motif chemokine. (101 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Dpep1	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
	I79_000380	Protein FAM19A4. (74 aa)
	I79_000930	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (509 aa)
	CgPICR_003438	C-C motif chemokine. (143 aa)
	I79_001072	C-C motif chemokine. (97 aa)
	I79_001073	C-C motif chemokine. (72 aa)
	Ccl1	C-C motif chemokine 1. (91 aa)
	Pde4d	Phosphodiesterase. (507 aa)
	Itga9	Integrin alpha-9; Belongs to the integrin alpha chain family. (976 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	I79_002099	Vascular endothelial growth factor receptor 1. (115 aa)
	Edn3	Endothelin-3. (274 aa)
	Il17rc	Interleukin-17 receptor C. (358 aa)
	Hrh1	Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	Ano6	Anoctamin. (319 aa)
	Spp1	Osteopontin. (117 aa)
	H671_4g12987	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	Cxcr2	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	I79_025277	Anoctamin. (281 aa)
	I79_025400	Anoctamin. (273 aa)
	Trem1	Triggering receptor expressed on myeloid cells 1. (92 aa)
	I79_025437	Junctional adhesion molecule-like. (340 aa)
	I79_025515	High affinity interleukin-8 receptor A; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	Sbds	Ribosome maturation protein SBDS. (181 aa)
	S1pr1	Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	I79_022792	Signal recognition particle 54 kDa protein. (71 aa)
	Cxcr3	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (286 aa)
	I79_022271	Ras-related C3 botulinum toxin substrate 2. (178 aa)
	Alox5	Arachidonate 5-lipoxygenase. (674 aa)
	I79_021859	Protein FAM19A3. (124 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1017 aa)
	Scg2	Secretogranin-2. (763 aa)
	Adam8	Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
	I79_020316	Guanine nucleotide exchange factor VAV3. (604 aa)
	Slc37a4	Glucose-6-phosphate translocase. (285 aa)
	Mdk	Midkine. (160 aa)
	Myo9b	Myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1987 aa)
	Ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	Cklf	Chemokine-like factor-like protein. (149 aa)
	Cxadr	Coxsackievirus and adenovirus receptor-like. (394 aa)
	Lgals3	Galectin. (281 aa)
	Il17ra	Interleukin-17 receptor A. (865 aa)
	Lrrc3	Transient receptor potential cation channel subfamily M member 2. (1604 aa)
	Itgb2	Integrin beta. (769 aa)
	I79_007196	60S ribosomal protein L13a. (146 aa)
	Csf3r	Granulocyte colony-stimulating factor receptor. (841 aa)
	I79_007229	Receptor-type tyrosine-protein phosphatase O. (1056 aa)
	Ptn	Pleiotrophin. (168 aa)
	I79_008231	Proto-oncogene vav. (879 aa)
	I79_008250	Endothelin-2. (137 aa)
	I79_008766	Integrin alpha-1; Belongs to the integrin alpha chain family. (1854 aa)
	I79_008828	Lymphotactin. (114 aa)
	I79_008865	60S ribosomal protein L13a. (138 aa)
	I79_009191	Basigin. (437 aa)
	Gpr183	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	Tnfsf11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
	I79_010290	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	Syk	Tyrosine-protein kinase. (611 aa)
	Ccl22	C-C motif chemokine. (93 aa)
	Cx3cl1	Fractalkine. (335 aa)
	Ccl17	C-C motif chemokine. (93 aa)
	Arhgef5	Rho guanine nucleotide exchange factor 5. (1561 aa)
	Pde4b	Phosphodiesterase. (517 aa)
	I79_011955	60S ribosomal protein L13a. (112 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Ninj1	Ninjurin-1. (102 aa)
	Cx3cr1	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	Ch25h	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (284 aa)
	I79_013771	Calcitonin. (206 aa)
	I79_014453	1-phosphatidylinositol-3-phosphate 5-kinase. (266 aa)
	I79_020109	Glucose-6-phosphate translocase. (141 aa)
	I79_014455	1-phosphatidylinositol-3-phosphate 5-kinase. (306 aa)
	Chga	Chromogranin-A. (434 aa)
	I79_015453	C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	Ccr3	Putative C-C chemokine receptor type 3-like protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	Gbf1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1. (1857 aa)
	Trpm4	Transient receptor potential cation channel subfamily M member 4. (315 aa)
	Rpl13a	60S ribosomal protein L13a. (117 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Pdgfb	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	I79_017861	Solute carrier family 12 member 2. (706 aa)
	I79_018112	Lysosomal-trafficking regulator. (3383 aa)
	I79_018245	C-X-C motif chemokine. (322 aa)
	I79_018247	C-X-C motif chemokine 15. (63 aa)
	Cxcl1	C-X-C motif chemokine. (101 aa)
	I79_018349	Coronin-1A. (143 aa)
	Anxa1	Annexin. (346 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	CgPICR_003405	C-C motif chemokine. (98 aa)
	CgPICR_003404	C-C motif chemokine. (92 aa)
	I79_019038	Nck-associated protein 1-like. (1065 aa)
	Hsd3b7	3 beta-hydroxysteroid dehydrogenase type 7; Belongs to the 3-beta-HSD family. (369 aa)
	Gas6	Growth arrest-specific protein 6. (684 aa)
	I79_019663	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (216 aa)
	I79_019770	Protein S100; Belongs to the S-100 family. (124 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Srp54	Signal recognition particle 54 kDa protein. (272 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ano6	I79_025277	G3IJF3	G3IMX2	Anoctamin.	Anoctamin.	0.928
Ano6	I79_025400	G3IJF3	G3IN88	Anoctamin.	Anoctamin.	0.922
Anxa1	IL1B	G3I5L3	G3I1B0	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.500
Anxa1	Lgals3	G3I5L3	G3H7B3	Annexin.	Galectin.	0.550
Ccl1	Ccl17	G3GTT6	G3HIL3	C-C motif chemokine 1.	C-C motif chemokine.	0.747
Ccl1	Ccl19	G3GTT6	G3HN20	C-C motif chemokine 1.	C-C motif chemokine.	0.527
Ccl1	Ccl21	G3GTT6	G3HN19	C-C motif chemokine 1.	C-C motif chemokine 21a.	0.471
Ccl1	Ccl22	G3GTT6	G3HIL1	C-C motif chemokine 1.	C-C motif chemokine.	0.695
Ccl1	Ccl5	G3GTT6	G3I8B1	C-C motif chemokine 1.	C-C motif chemokine.	0.765
Ccl1	Ccr3	G3GTT6	G3HWU2	C-C motif chemokine 1.	Putative C-C chemokine receptor type 3-like protein; Belongs to the G-protein coupled receptor 1 family.	0.855
Ccl1	Ccr7	G3GTT6	G3I5N8	C-C motif chemokine 1.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.823
Ccl1	CgPICR_003404	G3GTT6	G3I641	C-C motif chemokine 1.	C-C motif chemokine.	0.505
Ccl1	CgPICR_003405	G3GTT6	G3I640	C-C motif chemokine 1.	C-C motif chemokine.	0.480
Ccl1	CgPICR_003438	G3GTT6	G3GTT2	C-C motif chemokine 1.	C-C motif chemokine.	0.555
Ccl1	CgPICR_014700	G3GTT6	G3HWU4	C-C motif chemokine 1.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.861
Ccl1	Cx3cl1	G3GTT6	G3HIL2	C-C motif chemokine 1.	Fractalkine.	0.525
Ccl1	Cx3cr1	G3GTT6	G3HQW7	C-C motif chemokine 1.	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.964
Ccl1	Cxcl1	G3GTT6	G3I473	C-C motif chemokine 1.	C-X-C motif chemokine.	0.631
Ccl1	Cxcr2	G3GTT6	G3IMN7	C-C motif chemokine 1.	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family.	0.834
Ccl1	Cxcr3	G3GTT6	G3IF30	C-C motif chemokine 1.	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family.	0.804