(45 nodes) Negative regulation of epithelial cell differentiation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tbx3	T-box transcription factor TBX3. (709 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	I79_025679	Forkhead box protein P4. (346 aa)
	Foxp1	Forkhead box protein P1. (696 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	I79_025680	Forkhead box protein P4. (206 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	I79_023436	Forkhead box protein P4. (104 aa)
	I79_023429	Forkhead box protein P4. (631 aa)
	Acvrl1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
	Foxj2	Forkhead box protein J2. (573 aa)
	Xdh	Xanthine dehydrogenase/oxidase. (1332 aa)
	Gdf3	Growth/differentiation factor 3. (361 aa)
	Foxp4	Forkhead box protein P4. (685 aa)
	Gpsm3	Neurogenic locus notch-like protein 4. (1797 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Spry1	Protein sprouty-like 1. (313 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Zeb1	Zinc finger E-box-binding homeobox 1. (1078 aa)
	I79_011377	Grainyhead-like protein 2-like. (522 aa)
	S1pr3	Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	Spred1	Sprouty-related, EVH1 domain-containing protein 1. (370 aa)
	Nkx6-3	Homeobox protein Nkx-6.3. (262 aa)
	Id1	DNA-binding protein inhibitor ID-1. (157 aa)
	Fst	Follistatin. (316 aa)
	Osr1	Protein odd-skipped-related 1. (266 aa)
	Srsf6	Splicing factor, arginine/serine-rich 6. (210 aa)
	Hoxa7	Homeobox protein Hox-A7. (112 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Mmp9	Matrix metalloproteinase-9. (710 aa)
	I79_006675	Secreted frizzled-related protein 3. (286 aa)
	Tgfbr1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
	Nodal	Nodal. (309 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Spred2	Sprouty-related, EVH1 domain-containing protein 2. (415 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Ezh2	Histone-lysine N-methyltransferase EZH2. (746 aa)
	Vhl	Von Hippel-Lindau disease tumor suppressor. (134 aa)
	Six2	Homeobox protein SIX2. (299 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acvrl1	Nodal	G3IC00	G3H6S2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal.	0.401
Acvrl1	Tgfbr1	G3IC00	G3H7H0	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.444
Cav1	Ccnd1	G3H9I8	A5A422	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.411
Cav1	Ctnnb1	G3H9I8	G3H996	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta-1.	0.689
Cav1	Mmp9	G3H9I8	G3H8V1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Matrix metalloproteinase-9.	0.427
Cav1	Spred1	G3H9I8	G3HHV7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty-related, EVH1 domain-containing protein 1.	0.480
Cav1	Spred2	G3H9I8	G3H119	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty-related, EVH1 domain-containing protein 2.	0.457
Ccnd1	Cav1	A5A422	G3H9I8	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.411
Ccnd1	Ctnnb1	A5A422	G3H996	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Catenin beta-1.	0.706
Ccnd1	Ezh2	A5A422	G3GXG1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Histone-lysine N-methyltransferase EZH2.	0.412
Ccnd1	Jag1	A5A422	G3GSA7	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.529
Ccnd1	Mmp9	A5A422	G3H8V1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Matrix metalloproteinase-9.	0.743
Ccnd1	Zeb1	A5A422	G3HN44	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Zinc finger E-box-binding homeobox 1.	0.461
Ctnnb1	Cav1	G3H996	G3H9I8	Catenin beta-1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.689
Ctnnb1	Ccnd1	G3H996	A5A422	Catenin beta-1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.706
Ctnnb1	Dll1	G3H996	G3HNT7	Catenin beta-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.450
Ctnnb1	Ezh2	G3H996	G3GXG1	Catenin beta-1.	Histone-lysine N-methyltransferase EZH2.	0.701
Ctnnb1	I79_000973	G3H996	G3GTI9	Catenin beta-1.	Transcription factor SOX-10.	0.781
Ctnnb1	I79_001484	G3H996	G3GUW0	Catenin beta-1.	65 kDa Yes-associated protein.	0.812
Ctnnb1	I79_006675	G3H996	G3H8H5	Catenin beta-1.	Secreted frizzled-related protein 3.	0.497