(26 nodes) Thyroid gland development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_003741	Dual oxidase 2. (1367 aa)
	I79_025880	Thyroid hormone receptor alpha. (77 aa)
	I79_005672	Homeobox protein Hox-B3. (174 aa)
	Map2k1	Dual specificity mitogen-activated protein kinase kinase 1. (101 aa)
	I79_025358	Thyroglobulin. (227 aa)
	Hhex	Hematopoietically-expressed homeobox protein Hhex. (98 aa)
	Edn1	Endothelin-1. (202 aa)
	I79_024992	Thyroglobulin. (241 aa)
	Pax8	Paired box protein Pax-8. (452 aa)
	I79_022078	Homeobox protein Nkx-2.1. (190 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Thra	Thyroid hormone receptor alpha. (493 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	I79_016797	Dual specificity mitogen-activated protein kinase kinase 1. (129 aa)
	Srf	Serum response factor. (361 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Map2k2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (380 aa)
	I79_009740	B-Raf proto-oncogene serine/threonine-protein kinase. (229 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	I79_009030	T-box transcription factor TBX1. (293 aa)
	Hoxa3	Homeobox protein Hox-A3. (286 aa)
	I79_007135	Homeobox protein Nkx-2.5. (223 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Edn1	Ednra	G3H0G9	G3H9A8	Endothelin-1.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.999
Edn1	I79_019149	G3H0G9	G3I6M4	Endothelin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.475
Edn1	Npm3	G3H0G9	G3HXU8	Endothelin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.475
Ednra	Edn1	G3H9A8	G3H0G9	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1.	0.999
Hhex	Hoxa3	G3IN11	G3HD72	Hematopoietically-expressed homeobox protein Hhex.	Homeobox protein Hox-A3.	0.607
Hhex	Pax8	G3IN11	G3IET9	Hematopoietically-expressed homeobox protein Hhex.	Paired box protein Pax-8.	0.513
Hoxa3	Hhex	G3HD72	G3IN11	Homeobox protein Hox-A3.	Hematopoietically-expressed homeobox protein Hhex.	0.607
Hoxa3	I79_005672	G3HD72	G3H5T1	Homeobox protein Hox-A3.	Homeobox protein Hox-B3.	0.768
Hoxa3	Pax8	G3HD72	G3IET9	Homeobox protein Hox-A3.	Paired box protein Pax-8.	0.417
I79_005672	Hoxa3	G3H5T1	G3HD72	Homeobox protein Hox-B3.	Homeobox protein Hox-A3.	0.768
I79_006225	I79_019149	G3H796	G3I6M4	Sonic hedgehog protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
I79_006225	Npm3	G3H796	G3HXU8	Sonic hedgehog protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
I79_007135	I79_009030	G3H9Q5	G3HEP2	Homeobox protein Nkx-2.5.	T-box transcription factor TBX1.	0.598
I79_007135	Srf	G3H9Q5	G3HYT2	Homeobox protein Nkx-2.5.	Serum response factor.	0.670
I79_009030	I79_007135	G3HEP2	G3H9Q5	T-box transcription factor TBX1.	Homeobox protein Nkx-2.5.	0.598
I79_009500	I79_009740	G3HFY3	G3HGK2	Mitogen-activated protein kinase 1.	B-Raf proto-oncogene serine/threonine-protein kinase.	0.637
I79_009500	I79_016797	G3HFY3	G3I0B8	Mitogen-activated protein kinase 1.	Dual specificity mitogen-activated protein kinase kinase 1.	0.868
I79_009500	Map2k1	G3HFY3	G3INJ6	Mitogen-activated protein kinase 1.	Dual specificity mitogen-activated protein kinase kinase 1.	0.899
I79_009500	Map2k2	G3HFY3	G3HSM1	Mitogen-activated protein kinase 1.	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.911
I79_009500	Mapk3	G3HFY3	G3I4H1	Mitogen-activated protein kinase 1.	Mitogen-activated protein kinase.	0.606