(63 nodes) Midbrain development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kdm2b	Lysine-specific demethylase 2B. (1305 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Smad1	Mothers against decapentaplegic-like 1. (232 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	I79_008405	Tyrosine-protein kinase RYK. (141 aa)
	I79_008642	Homeobox protein OTX1. (339 aa)
	I79_021938	Mothers against decapentaplegic-like 1. (122 aa)
	I79_021890	Disks large-like 5. (101 aa)
	I79_021503	Paired mesoderm homeobox protein 2A. (139 aa)
	I79_021448	Disks large-like 5. (270 aa)
	I79_021447	Disks large-like 5. (129 aa)
	I79_021446	Disks large-like 5. (133 aa)
	I79_021445	Disks large-like 5. (294 aa)
	I79_019981	Lysine-specific demethylase 2B. (484 aa)
	I79_019973	Disks large-like 5. (219 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_018593	Disks large-like 5. (121 aa)
	I79_018312	Tyrosine-protein kinase RYK. (163 aa)
	I79_018043	Frizzled-6. (109 aa)
	I79_015873	Pituitary homeobox 3. (214 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Wls	Integral membrane protein GPR177. (166 aa)
	Uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	I79_013795	Disks large-like 5. (96 aa)
	Smad9	Mothers against decapentaplegic homolog. (465 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (319 aa)
	Kat2a	Histone acetyltransferase KAT2A. (663 aa)
	I79_012761	LIM homeobox transcription factor 1-alpha. (88 aa)
	Lmx1a	LIM homeobox transcription factor 1-alpha. (333 aa)
	I79_012895	Transcription factor AP-2 delta. (352 aa)
	Otx2	Homeobox protein OTX2. (289 aa)
	I79_013668	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1. (809 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (148 aa)
	Foxb1	Forkhead box protein B1. (325 aa)
	I79_001115	Amyloid-like protein 2. (682 aa)
	Tal2	T-cell acute lymphocytic leukemia protein 2. (108 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	I79_025783	Mothers against decapentaplegic-like 1. (97 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	I79_025513	Mothers against decapentaplegic-like 1. (151 aa)
	I79_025487	Disks large-like 5. (92 aa)
	I79_025459	Mothers against decapentaplegic-like 1. (117 aa)
	I79_025450	Disks large-like 5. (167 aa)
	I79_025338	Disks large-like 5. (203 aa)
	I79_025316	Mothers against decapentaplegic-like 1. (104 aa)
	I79_025180	Disks large-like 5. (144 aa)
	Cxcr2	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	I79_024959	Mothers against decapentaplegic-like 1. (161 aa)
	I79_024447	Disks large-like 5. (99 aa)
	I79_024446	Disks large-like 5. (162 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	Hes3	Transcription factor HES-3. (201 aa)
	Padi2	Protein-arginine deiminase type-2. (650 aa)
	I79_022271	Ras-related C3 botulinum toxin substrate 2. (178 aa)
	I79_022205	Disks large-like 5. (99 aa)
	Msx1	Homeobox protein MSX-1. (261 aa)
	Dlg5	Disks large-like 5; Belongs to the MAGUK family. (1873 aa)
	Fzd3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ctnnb1	Fgfr2	G3H996	G3IJY0	Catenin beta-1.	Fibroblast growth factor receptor 2.	0.527
Ctnnb1	Fzd3	G3H996	G3H0J5	Catenin beta-1.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
Ctnnb1	I79_004031	G3H996	G3H1K2	Catenin beta-1.	Fibroblast growth factor receptor.	0.690
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_007641	G3H996	G3HB26	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	I79_010136	G3H996	G3HHN2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.760
Ctnnb1	I79_015873	G3H996	G3HXV8	Catenin beta-1.	Pituitary homeobox 3.	0.423
Ctnnb1	I79_018043	G3H996	G3I3N3	Catenin beta-1.	Frizzled-6.	0.563
Ctnnb1	I79_022271	G3H996	G3IEW6	Catenin beta-1.	Ras-related C3 botulinum toxin substrate 2.	0.588
Ctnnb1	Lrp6	G3H996	G3HB27	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	Rac1	G3H996	G3GVB5	Catenin beta-1.	Ras-related C3 botulinum toxin substrate 1.	0.588
Ctnnb1	Wnt1	G3H996	G3I6J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.785
Ctnnb1	Wnt2	G3H996	G3H9J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.684
Ctnnb1	Wnt5a	G3H996	G3GUT6	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.628
Ctnnb1	Wnt9b	G3H996	G3IP03	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.443
Fgfr2	Ctnnb1	G3IJY0	G3H996	Fibroblast growth factor receptor 2.	Catenin beta-1.	0.527
Fgfr2	Fgfr3	G3IJY0	G3HK77	Fibroblast growth factor receptor 2.	Fibroblast growth factor receptor 3.	0.960
Fgfr2	I79_004031	G3IJY0	G3H1K2	Fibroblast growth factor receptor 2.	Fibroblast growth factor receptor.	0.429
Fgfr3	Fgfr2	G3HK77	G3IJY0	Fibroblast growth factor receptor 3.	Fibroblast growth factor receptor 2.	0.960
Fgfr3	I79_004031	G3HK77	G3H1K2	Fibroblast growth factor receptor 3.	Fibroblast growth factor receptor.	0.602