(30 nodes) Developmental induction network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Hoxa11	Homeobox protein Hox-A11. (250 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	I79_008847	POU domain protein. (621 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	I79_009364	Transcription factor AP-2 alpha. (411 aa)
	CUNH12orf43	Uncharacterized protein C12orf43-like. (261 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Sox2	Transcription factor SOX-2. (273 aa)
	I79_013082	Homeodomain-interacting protein kinase 1. (1249 aa)
	Spry1	Protein sprouty-like 1. (313 aa)
	Fzd5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (616 aa)
	I79_014806	Homeobox protein Hox-C11. (229 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_022078	Homeobox protein Nkx-2.1. (190 aa)
	Wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	I79_003906	Fibroblast growth factor receptor 4. (1040 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	Ctnnb1	Catenin beta-1. (781 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ctnnb1	Fzd5	G3H996	G3HU61	Catenin beta-1.	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.529
Ctnnb1	I79_000973	G3H996	G3GTI9	Catenin beta-1.	Transcription factor SOX-10.	0.781
Ctnnb1	I79_003906	G3H996	G3H181	Catenin beta-1.	Fibroblast growth factor receptor 4.	0.448
Ctnnb1	I79_004031	G3H996	G3H1K2	Catenin beta-1.	Fibroblast growth factor receptor.	0.690
Ctnnb1	I79_006254	G3H996	G3H7C4	Catenin beta-1.	Bone morphogenetic protein 4.	0.448
Ctnnb1	Sox2	G3H996	G3HJZ4	Catenin beta-1.	Transcription factor SOX-2.	0.771
Ctnnb1	Sox8	G3H996	G3HBV8	Catenin beta-1.	Transcription factor SOX-8.	0.589
Ctnnb1	Wnt1	G3H996	G3I6J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.785
Ctnnb1	Wnt2	G3H996	G3H9J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.684
Ctnnb1	Wnt2b	G3H996	G3IH40	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.603
Ctnnb1	Wnt4	G3H996	G3HIM9	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.679
Fgf1	Fgf3	G3HEK8	G3I4D7	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.503
Fgf1	Frs2	G3HEK8	G3HZ39	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2.	0.651
Fgf1	Gdnf	G3HEK8	G3HJV8	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Glial cell line-derived neurotrophic factor.	0.485
Fgf1	I79_003906	G3HEK8	G3H181	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor 4.	0.928
Fgf1	I79_004031	G3HEK8	G3H1K2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor.	0.980
Fgf1	I79_019149	G3HEK8	G3I6M4	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
Fgf1	Npm3	G3HEK8	G3HXU8	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.427
Fgf3	Fgf1	G3I4D7	G3HEK8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.503
Fgf3	Frs2	G3I4D7	G3HZ39	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2.	0.694