(82 nodes) Brush border membrane network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_000806	Heat shock cognate protein HSP 90-beta. (102 aa)
	Slc9a3r1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (354 aa)
	Slc46a1	Proton-coupled folate transporter. (459 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	I79_001265	Cytochrome b reductase 1. (284 aa)
	Slc3a1	Neutral and basic amino acid transport protein rBAT. (364 aa)
	Gna12	Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
	I79_002010	Phospholipase B1, membrane-associated. (995 aa)
	Drd5	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (403 aa)
	Kcnk1	Potassium channel subfamily K member 1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (225 aa)
	I79_002280	Potassium channel subfamily K member 1. (204 aa)
	Slc5a6	Sodium-dependent multivitamin transporter. (204 aa)
	I79_002574	Sodium-dependent multivitamin transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (466 aa)
	Slc34a1	Sodium-dependent phosphate transport protein 2A. (629 aa)
	Cdhr2	Cadherin-related family member 2-like protein. (1330 aa)
	Pdzk1	Na(+)/H(+) exchange regulatory cofactor NHE-RF3. (523 aa)
	Hsp90aa1	Heat shock protein HSP 90-alpha. (332 aa)
	Pcmt1	Protein-L-isoaspartate(D-aspartate) O-methyltransferase. (100 aa)
	I79_005534	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1145 aa)
	I79_006467	Intelectin-1a. (290 aa)
	I79_006468	Intelectin-1a. (333 aa)
	I79_006469	Intelectin-1a. (315 aa)
	Pex19	Peroxisomal biogenesis factor 19. (299 aa)
	Gna13	Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
	Ca4	Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (310 aa)
	I79_007529	Cystine/glutamate transporter. (437 aa)
	I79_007634	Heat shock protein HSP 90-beta. (176 aa)
	I79_008088	Heat shock protein HSP 90-beta. (412 aa)
	I79_009115	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
	I79_009116	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
	Slc7a9	B(0,+)-type amino acid transporter 1. (476 aa)
	I79_009982	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
	I79_009987	Collectrin. (118 aa)
	H671_xg20748	Angiotensin-converting enzyme. (644 aa)
	PEMT	Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (189 aa)
	I79_010173	Cubilin. (1951 aa)
	Aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	Slc5a1	Sodium/glucose cotransporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (664 aa)
	Slc26a6	Solute carrier family 26 member 6. (637 aa)
	I79_011304	Parathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family. (626 aa)
	Npc1l1	Niemann-Pick C1-like protein 1. (1328 aa)
	Slc28a2	Sodium/nucleoside cotransporter 2. (625 aa)
	I79_011940	Platelet glycoprotein 4; Belongs to the CD36 family. (348 aa)
	Atp7a	Copper-transporting ATPase 1. (1457 aa)
	I79_012961	SH3 and multiple ankyrin repeat domains protein 2. (1121 aa)
	I79_013640	Heat shock protein HSP 90-alpha. (249 aa)
	I79_014369	Intelectin-1a. (279 aa)
	I79_014372	Intelectin-1a. (626 aa)
	Lima1	LIM domain and actin-binding protein 1. (759 aa)
	I79_016292	Heat shock protein HSP 90-alpha. (205 aa)
	I79_016293	Heat shock protein HSP 90-alpha 1. (135 aa)
	Mfsd10	Major facilitator superfamily domain-containing protein 10. (456 aa)
	Cbll1	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (986 aa)
	I79_017503	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (651 aa)
	I79_017967	Mucin and cadherin-like protein. (611 aa)
	I79_018653	Heat shock protein HSP 90-beta. (131 aa)
	Slc22a12	Solute carrier family 22 member 12. (553 aa)
	B4galt1	Beta-1,4-galactosyltransferase 1. (258 aa)
	Slc2a2	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (351 aa)
	I79_020270	Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (492 aa)
	Slc27a4	Long-chain fatty acid transport protein 4. (643 aa)
	Slc34a2	Sodium-dependent phosphate transport protein 2B. (694 aa)
	I79_021138	Heat shock protein HSP 90-beta. (90 aa)
	I79_021139	Heat shock protein HSP 90-beta. (113 aa)
	Cutc	Canalicular multispecific organic anion transporter 1. (1555 aa)
	I79_021590	Heat shock protein HSP 90-beta. (121 aa)
	H671_2g5523	Rap guanine nucleotide exchange factor 3-like protein. (979 aa)
	I79_022009	Transient receptor potential cation channel subfamily M member 6. (1577 aa)
	Slc11a2	Natural resistance-associated macrophage protein 2. (474 aa)
	Slc34a3	Sodium-dependent phosphate transport protein 2C. (598 aa)
	I79_025269	Glutamyl aminopeptidase. (84 aa)
	Enpep	Glutamyl aminopeptidase. (372 aa)
	Slc9a3	Sodium/hydrogen exchanger 3. (99 aa)
	Folr1	Folate receptor alpha. (257 aa)
	I79_023505	Solute carrier family 28 member 3. (394 aa)
	Slc6a19	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (661 aa)
	Slc6a18	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (557 aa)
	I79_024082	Heat shock protein HSP 90-beta. (166 aa)
	Slc5a2	Sodium/glucose cotransporter 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (674 aa)
	I79_024580	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (612 aa)
	I79_024796	Aminopeptidase N. (493 aa)
	Anpep	Aminopeptidase N. (325 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anpep	H671_xg20748	G3ILR8	G3HH90	Aminopeptidase N.	Angiotensin-converting enzyme.	0.604
Anpep	I79_009987	G3ILR8	G3HH89	Aminopeptidase N.	Collectrin.	0.514
Anpep	I79_024796	G3ILR8	G3ILM6	Aminopeptidase N.	Aminopeptidase N.	0.835
Cdhr2	I79_017967	G3H190	G3I3G0	Cadherin-related family member 2-like protein.	Mucin and cadherin-like protein.	0.884
Cutc	Pdzk1	G3IBW1	G3H2R4	Canalicular multispecific organic anion transporter 1.	Na(+)/H(+) exchange regulatory cofactor NHE-RF3.	0.441
Cutc	Slc2a2	G3IBW1	G3I947	Canalicular multispecific organic anion transporter 1.	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.476
Cutc	Slc9a3r1	G3IBW1	G3GTH2	Canalicular multispecific organic anion transporter 1.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.436
Drd5	Gna12	G3GWE8	G3GVE4	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit alpha-12.	0.420
Drd5	Gna13	G3GWE8	G3H860	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit alpha-13.	0.420
Enpep	I79_024796	G3IGC4	G3ILM6	Glutamyl aminopeptidase.	Aminopeptidase N.	0.576
Folr1	Slc46a1	G3II15	G3GTP5	Folate receptor alpha.	Proton-coupled folate transporter.	0.763
Gna12	Drd5	G3GVE4	G3GWE8	Guanine nucleotide-binding protein subunit alpha-12.	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.420
Gna12	Gna13	G3GVE4	G3H860	Guanine nucleotide-binding protein subunit alpha-12.	Guanine nucleotide-binding protein subunit alpha-13.	0.986
Gna13	Drd5	G3H860	G3GWE8	Guanine nucleotide-binding protein subunit alpha-13.	D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.420
Gna13	Gna12	G3H860	G3GVE4	Guanine nucleotide-binding protein subunit alpha-13.	Guanine nucleotide-binding protein subunit alpha-12.	0.986
H671_xg20748	Anpep	G3HH90	G3ILR8	Angiotensin-converting enzyme.	Aminopeptidase N.	0.604
H671_xg20748	I79_009987	G3HH90	G3HH89	Angiotensin-converting enzyme.	Collectrin.	0.436
H671_xg20748	I79_024796	G3HH90	G3ILM6	Angiotensin-converting enzyme.	Aminopeptidase N.	0.619
H671_xg20748	Pdzk1	G3HH90	G3H2R4	Angiotensin-converting enzyme.	Na(+)/H(+) exchange regulatory cofactor NHE-RF3.	0.403
H671_xg20748	Slc6a18	G3HH90	G3IIU1	Angiotensin-converting enzyme.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.730