(53 nodes) Regulation of myelination network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ctsc	Dipeptidyl-peptidase 1; Belongs to the peptidase C1 family. (483 aa)
	I79_019428	Integrin alpha-X; Belongs to the integrin alpha chain family. (1016 aa)
	I79_019031	Teneurin-4. (3477 aa)
	I79_018913	Homeobox protein Nkx-6.2. (114 aa)
	I79_018785	Retinoic acid receptor alpha. (484 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	I79_018449	Kallikrein-8; Belongs to the peptidase S1 family. (260 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Dicer1	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
	I79_014914	Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (756 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	I79_005213	Nuclear receptor domain-containing protein. (162 aa)
	Kif14	Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1633 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	I79_003225	Serotransferrin. (1227 aa)
	Fig4	Polyphosphoinositide phosphatase. (907 aa)
	H671_xg19992	Zinc finger protein ZPR1 isoform 1. (108 aa)
	Tmem98	Transmembrane protein 98. (226 aa)
	I79_002119	Wiskott-Aldrich syndrome protein family member 3. (421 aa)
	Slc25a12	Calcium-binding mitochondrial carrier protein Aralar1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (646 aa)
	I79_012760	Retinoic acid receptor RXR-gamma. (414 aa)
	Ptprz1	Receptor-type tyrosine-protein phosphatase zeta. (2289 aa)
	I79_011203	Partitioning defective 3-like. (1009 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	I79_010839	Eukaryotic translation initiation factor 2-alpha kinase 3. (783 aa)
	Sirt2	NAD-dependent deacetylase sirtuin-2. (83 aa)
	Rnf10	RING finger protein 10. (759 aa)
	I79_007629	Lipin-1. (895 aa)
	Ptn	Pleiotrophin. (168 aa)
	Nsun5	Putative methyltransferase NSUN5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (153 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Dag1	Dystroglycan. (893 aa)
	Rarg	Retinoic acid receptor gamma. (458 aa)
	Tnfrsf21	Tumor necrosis factor receptor superfamily member 21. (654 aa)
	I79_014098	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	Mtmr2	Myotubularin-related protein 2. (572 aa)
	Rxrb	Retinoic acid receptor RXR-beta. (101 aa)
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	S100b	Protein S100; Belongs to the S-100 family. (92 aa)
	Egr2	Early growth response protein 2. (410 aa)
	I79_025358	Thyroglobulin. (227 aa)
	I79_024992	Thyroglobulin. (241 aa)
	Tnfrsf1b	Tumor necrosis factor receptor superfamily member 1B. (477 aa)
	Tcf7l2	Transcription factor 7-like 1. (73 aa)
	Tppp	Tubulin polymerization-promoting protein. (236 aa)
	I79_022526	Myelin gene regulatory factor. (1095 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	Lgi4	Leucine-rich repeat LGI family member 4. (97 aa)
	I79_020783	Transcription factor 7-like 2. (451 aa)
	I79_019552	Zinc finger protein ZPR1. (503 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Ctnnb1	G3H397	G3H996	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Catenin beta-1.	0.790
Akt1	Hgf	G3H397	G3HPQ5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.494
Akt1	I79_014914	G3H397	G3HVC8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins.	0.455
Akt1	I79_018586	G3H397	G3I540	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.767
Akt1	Igf1	G3H397	G3H672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I.	0.710
Akt1	Mtor	G3H397	G3IEE8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.994
Akt1	Ngfr	G3H397	G3HJP7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor receptor superfamily member 16.	0.445
Akt1	Tnf	G3H397	G3HZG9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.636
Ctnnb1	Akt1	G3H996	G3H397	Catenin beta-1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.790
Ctnnb1	I79_011203	G3H996	G3HKH7	Catenin beta-1.	Partitioning defective 3-like.	0.519
Ctnnb1	I79_014914	G3H996	G3HVC8	Catenin beta-1.	Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins.	0.965
Ctnnb1	I79_018586	G3H996	G3I540	Catenin beta-1.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.628
Ctnnb1	I79_018785	G3H996	G3I5N2	Catenin beta-1.	Retinoic acid receptor alpha.	0.591
Ctnnb1	I79_020783	G3H996	G3IAZ7	Catenin beta-1.	Transcription factor 7-like 2.	0.956
Ctnnb1	Rxra	G3H996	G3IDY0	Catenin beta-1.	Retinoic acid receptor RXR-alpha.	0.440
Ctnnb1	Rxrb	G3H996	G3HQS1	Catenin beta-1.	Retinoic acid receptor RXR-beta.	0.606
Ctnnb1	Sirt2	G3H996	G3HJB7	Catenin beta-1.	NAD-dependent deacetylase sirtuin-2.	0.579
Ctnnb1	Sox10	G3H996	G3I510	Catenin beta-1.	Transcription factor SOX-10.	0.641
Ctnnb1	Tcf7l2	G3H996	G3IIN4	Catenin beta-1.	Transcription factor 7-like 1.	0.995
Ctnnb1	Tnf	G3H996	G3HZG9	Catenin beta-1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.412