(52 nodes) Protein destabilization network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fbxo4	F-box only protein 4. (248 aa)
	Ccdc88c	Protein Daple. (225 aa)
	I79_017613	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3486 aa)
	Isoc1	Isochorismatase domain-containing protein 1. (177 aa)
	I79_016874	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2. (92 aa)
	I79_016692	CREB-binding protein. (1054 aa)
	Rnf5	E3 ubiquitin-protein ligase RNF5. (180 aa)
	Siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	I79_016114	Isochorismatase domain-containing protein 2A, mitochondrial. (109 aa)
	I79_016113	Isochorismatase domain-containing protein 2B, mitochondrial. (181 aa)
	Gsn	Gelsolin. (658 aa)
	Cdc73	Parafibromin. (164 aa)
	I79_014650	Parafibromin. (260 aa)
	Ep300	Histone acetyltransferase p300. (2415 aa)
	Btrc	F-box/WD repeat-containing protein 1A. (488 aa)
	I79_013817	NAD-dependent deacetylase sirtuin-6. (334 aa)
	I79_013707	CREB-binding protein. (202 aa)
	I79_013706	CREB-binding protein. (759 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (508 aa)
	Mylk3	Vacuolar protein sorting-associated protein 35. (1427 aa)
	Cul3	Cullin-3; Belongs to the cullin family. (746 aa)
	I79_022945	Immunity-related GTPase family M protein. (285 aa)
	I79_024386	JmjC domain-containing protein 5. (455 aa)
	Trim21	52 kDa Ro protein. (463 aa)
	Plk1	Serine/threonine-protein kinase PLK. (602 aa)
	I79_025694	Derlin-1. (87 aa)
	I79_025745	Nuclear receptor subfamily 1 group D member 1. (226 aa)
	Rnf139	RING finger protein 139. (612 aa)
	I79_025846	Derlin-1. (54 aa)
	Pex2	Peroxisome assembly factor 1. (334 aa)
	I79_013004	F-box/WD repeat-containing protein 7. (709 aa)
	Xbp1	X-box binding protein 1 isoform 1. (330 aa)
	Hdac6	Histone deacetylase 6. (666 aa)
	I79_011258	Sentrin-specific protease 2. (314 aa)
	I79_011017	Immunity-related GTPase family M protein. (341 aa)
	H671_3g8974	F-box/WD repeat-containing protein 11. (122 aa)
	I79_010620	Alpha-synuclein; Belongs to the synuclein family. (166 aa)
	Id1	DNA-binding protein inhibitor ID-1. (157 aa)
	Commd1	COMM domain-containing protein 1. (188 aa)
	I79_008349	UV excision repair protein RAD23-like A. (316 aa)
	Fbxw9	F-box/WD repeat-containing protein 9. (458 aa)
	I79_008145	Zinc finger protein 605. (769 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Mul1	Mitochondrial ubiquitin ligase activator of NFKB 1. (321 aa)
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	Utp25	Digestive organ expansion factor-like. (524 aa)
	I79_003794	Calpain-3; Belongs to the peptidase C2 family. (934 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Htt	Huntingtin protein. (2928 aa)
	Mylip	E3 ubiquitin-protein ligase MYLIP. (417 aa)
	Gga3	ADP-ribosylation factor-binding protein GGA3. (685 aa)
	I79_000037	F-box/WD repeat-containing protein 11. (481 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Btrc	Cul3	G3I574	G3ICS3	F-box/WD repeat-containing protein 1A.	Cullin-3; Belongs to the cullin family.	0.861
Btrc	Fbxo4	G3I574	G3HHE8	F-box/WD repeat-containing protein 1A.	F-box only protein 4.	0.915
Btrc	H671_3g8974	G3I574	G3HJ61	F-box/WD repeat-containing protein 1A.	F-box/WD repeat-containing protein 11.	0.640
Btrc	I79_000037	G3I574	G3GR94	F-box/WD repeat-containing protein 1A.	F-box/WD repeat-containing protein 11.	0.639
Btrc	I79_013004	G3I574	G3HQA7	F-box/WD repeat-containing protein 1A.	F-box/WD repeat-containing protein 7.	0.559
Btrc	Plk1	G3I574	G3IN30	F-box/WD repeat-containing protein 1A.	Serine/threonine-protein kinase PLK.	0.679
Cdc73	I79_014650	G3HUN9	G3HUN7	Parafibromin.	Parafibromin.	0.950
Commd1	Cul3	G3HDR1	G3ICS3	COMM domain-containing protein 1.	Cullin-3; Belongs to the cullin family.	0.675
Commd1	Fbxw9	G3HDR1	G3HCV9	COMM domain-containing protein 1.	F-box/WD repeat-containing protein 9.	0.414
Commd1	I79_013004	G3HDR1	G3HQA7	COMM domain-containing protein 1.	F-box/WD repeat-containing protein 7.	0.414
Commd1	Mul1	G3HDR1	G3H9S8	COMM domain-containing protein 1.	Mitochondrial ubiquitin ligase activator of NFKB 1.	0.450
Commd1	Mylk3	G3HDR1	G3I8H3	COMM domain-containing protein 1.	Vacuolar protein sorting-associated protein 35.	0.482
Cul3	Btrc	G3ICS3	G3I574	Cullin-3; Belongs to the cullin family.	F-box/WD repeat-containing protein 1A.	0.861
Cul3	Commd1	G3ICS3	G3HDR1	Cullin-3; Belongs to the cullin family.	COMM domain-containing protein 1.	0.675
Cul3	Fbxo4	G3ICS3	G3HHE8	Cullin-3; Belongs to the cullin family.	F-box only protein 4.	0.747
Cul3	Fbxw9	G3ICS3	G3HCV9	Cullin-3; Belongs to the cullin family.	F-box/WD repeat-containing protein 9.	0.711
Cul3	H671_3g8974	G3ICS3	G3HJ61	Cullin-3; Belongs to the cullin family.	F-box/WD repeat-containing protein 11.	0.841
Cul3	I79_000037	G3ICS3	G3GR94	Cullin-3; Belongs to the cullin family.	F-box/WD repeat-containing protein 11.	0.841
Cul3	I79_008349	G3ICS3	G3HCY1	Cullin-3; Belongs to the cullin family.	UV excision repair protein RAD23-like A.	0.585
Cul3	I79_013004	G3ICS3	G3HQA7	Cullin-3; Belongs to the cullin family.	F-box/WD repeat-containing protein 7.	0.729