(37 nodes) Lipopolysaccharide-mediated signaling pathway network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Irak2	Interleukin-1 receptor-associated kinase-like 2. (626 aa)
	Nr2c2	Nuclear receptor subfamily 2 group C member 2. (596 aa)
	CgPICR_003438	C-C motif chemokine. (143 aa)
	Plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
	Prkce	Protein kinase C epsilon type. (137 aa)
	I79_001592	Protein kinase C epsilon type. (163 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	Nfkbia	NF-kappa-B inhibitor alpha. (224 aa)
	Mapk3	Mitogen-activated protein kinase. (408 aa)
	Cd14	Monocyte differentiation antigen CD14. (309 aa)
	CgPICR_003405	C-C motif chemokine. (98 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Mtdh	Protein LYRIC. (247 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	I79_008640	NF-kappa-B inhibitor alpha. (90 aa)
	I79_008639	NF-kappa-B inhibitor alpha. (52 aa)
	Ticam1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Cd180	CD180 antigen. (525 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	I79_021950	T-cell differentiation antigen CD6. (536 aa)
	I79_023218	Interferon regulatory factor 3. (377 aa)
	Bcl10	B-cell lymphoma/leukemia 10. (232 aa)
	Ptafr	Platelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	Lbp	Lipopolysaccharide-binding protein. (916 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Bcl10	G3H397	G3IMU1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	B-cell lymphoma/leukemia 10.	0.403
Akt1	Ccl5	G3H397	G3I8B1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	C-C motif chemokine.	0.421
Akt1	I79_007693	G3H397	G3HB72	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.835
Akt1	I79_009500	G3H397	G3HFY3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 1.	0.546
Akt1	I79_023218	G3H397	G3IHC9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interferon regulatory factor 3.	0.443
Akt1	IL1B	G3H397	G3I1B0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.594
Akt1	Lyn	G3H397	G3I2D1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.484
Akt1	Mapk14	G3H397	G3HZU1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.963
Akt1	Mapk3	G3H397	G3I4H1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.947
Akt1	Myd88	G3H397	G3HQV3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.545
Akt1	Plcg2	G3H397	G3GRN8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.474
Akt1	Stat1	G3H397	G3I9F9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.672
Akt1	Tgfb1	G3H397	G3IA12	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta-1.	0.589
Akt1	Tlr4	G3H397	G3I192	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.501
Akt1	Tnf	G3H397	G3HZG9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.636
Bcl10	Akt1	G3IMU1	G3H397	B-cell lymphoma/leukemia 10.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.403
Bcl10	I79_001592	G3IMU1	G3GV61	B-cell lymphoma/leukemia 10.	Protein kinase C epsilon type.	0.424
Bcl10	I79_008639	G3IMU1	G3HDQ3	B-cell lymphoma/leukemia 10.	NF-kappa-B inhibitor alpha.	0.446
Bcl10	I79_008640	G3IMU1	G3HDQ4	B-cell lymphoma/leukemia 10.	NF-kappa-B inhibitor alpha.	0.446
Bcl10	Mapk14	G3IMU1	G3HZU1	B-cell lymphoma/leukemia 10.	Mitogen-activated protein kinase.	0.908