STRINGSTRING
Ntrk3 Ntrk3 Dynap Dynap I79_024271 I79_024271 Ntf3 Ntf3 Wnt5a Wnt5a I79_002035 I79_002035 Src Src Adra2b Adra2b Il18 Il18 Fgf1 Fgf1 Igf1 Igf1 Tcl1a Tcl1a I79_010470 I79_010470 Ccdc88a Ccdc88a Slc1a1 Slc1a1 I79_014015 I79_014015 I79_014451 I79_014451 Insr Insr I79_017397 I79_017397 I79_017398 I79_017398 Pdgfb Pdgfb Kctd5 Kctd5 Adra2a Adra2a Gas6 Gas6 I79_021789 I79_021789 H671_2g5844 H671_2g5844 Itgb1bp1 Itgb1bp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ntrk3Tyrosine-protein kinase receptor. (226 aa)
DynapCLLAC domain-containing protein. (165 aa)
I79_024271NT-3 growth factor receptor. (114 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_002035Alpha-2C adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (230 aa)
SrcTyrosine-protein kinase. (536 aa)
Adra2bAlpha-2B adrenergic receptor. (449 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Igf1Insulin-like growth factor I. (75 aa)
Tcl1aT-cell leukemia/lymphoma protein 1A. (105 aa)
I79_010470Metallothionein-3; Belongs to the metallothionein superfamily. Type 1 family. (108 aa)
Ccdc88aGirdin. (1664 aa)
Slc1a1Amino acid transporter. (492 aa)
I79_014015Oxysterol-binding protein; Belongs to the OSBP family. (472 aa)
I79_014451Pro-neuregulin-1, membrane-bound isoform. (639 aa)
InsrInsulin receptor. (114 aa)
I79_017397Protein kinase C zeta type. (280 aa)
I79_017398Protein kinase C zeta type. (53 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Kctd53-phosphoinositide-dependent protein kinase 1; Belongs to the peptidase S1 family. (799 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
Gas6Growth arrest-specific protein 6. (684 aa)
I79_021789NT-3 growth factor receptor. (389 aa)
H671_2g5844T-cell leukemia/lymphoma protein 1A-like protein. (115 aa)
Itgb1bp1Integrin beta-1-binding protein 1. (199 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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