(34 nodes) Regulation of intracellular estrogen receptor signaling pathway network (Cricetulus griseus)

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Predicted Interactions

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Your Input:
	I79_023104	CCR4-NOT transcription complex subunit 2. (417 aa)
	Vps18	Vacuolar protein sorting-associated protein 18-like. (973 aa)
	Vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (965 aa)
	Foxa1	Hepatocyte nuclear factor 3-alpha. (434 aa)
	I79_019663	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (216 aa)
	I79_019286	Androgen receptor. (295 aa)
	I79_019113	Histone-lysine N-methyltransferase MLL2. (1475 aa)
	Kmt2d	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (4002 aa)
	Pagr1	PAXIP1-associated protein 1. (251 aa)
	Foxh1	Forkhead box protein H1. (367 aa)
	Cnot1	CCR4-NOT transcription complex subunit 1. (1520 aa)
	I79_017776	CCR4-NOT transcription complex subunit 1. (660 aa)
	Ufsp2	Ufm1-specific protease 2. (461 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	Phb2	Prohibitin-2. (396 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)
	Lbh	Protein LBH. (88 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Uba5	Ubiquitin-like modifier-activating enzyme 5. (359 aa)
	Lats1	Serine/threonine-protein kinase LATS1. (1130 aa)
	I79_005032	DDRGK domain-containing protein 1. (345 aa)
	I79_005195	Striatin-3. (593 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	I79_005864	Histone-arginine methyltransferase CARM1. (94 aa)
	I79_006792	DUF1518 domain-containing protein. (200 aa)
	Ncoa3	Nuclear receptor coactivator 3. (1211 aa)
	Znf366	Zinc finger protein 366. (726 aa)
	Skp2	S-phase kinase-associated protein 2. (424 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Wbp2	WW domain-binding protein 2. (261 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (971 aa)
	Cnot9	Cell differentiation protein RCD1-like. (299 aa)
	Pak1	Serine/threonine-protein kinase PAK 1. (325 aa)
	Ar	Androgen receptor. (517 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	Brca1	G3IGU9	G3HM05	Androgen receptor.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.509
Ar	Foxa1	G3IGU9	G3I810	Androgen receptor.	Hepatocyte nuclear factor 3-alpha.	0.745
Ar	I79_006792	G3IGU9	G3H8T1	Androgen receptor.	DUF1518 domain-containing protein.	0.790
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Med1	G3IGU9	G3H5X2	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.485
Ar	Ncoa3	G3IGU9	G3H8T2	Androgen receptor.	Nuclear receptor coactivator 3.	0.790
Ar	Src	G3IGU9	G3GXX7	Androgen receptor.	Tyrosine-protein kinase.	0.571
Brca1	Ar	G3HM05	G3IGU9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Androgen receptor.	0.509
Brca1	I79_019286	G3HM05	G3I705	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Androgen receptor.	0.424
Brca1	Parp1	G3HM05	G3HV73	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.755
Brca1	Tp63	G3HM05	G3GT84	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.530
Cnot1	Cnot9	G3I2X8	G3HWH2	CCR4-NOT transcription complex subunit 1.	Cell differentiation protein RCD1-like.	0.979
Cnot1	I79_017776	G3I2X8	G3I2X9	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 1.	0.962
Cnot1	I79_023104	G3I2X8	G3IH26	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.980
Cnot9	Cnot1	G3HWH2	G3I2X8	Cell differentiation protein RCD1-like.	CCR4-NOT transcription complex subunit 1.	0.979
Cnot9	I79_017776	G3HWH2	G3I2X9	Cell differentiation protein RCD1-like.	CCR4-NOT transcription complex subunit 1.	0.979
Cnot9	I79_023104	G3HWH2	G3IH26	Cell differentiation protein RCD1-like.	CCR4-NOT transcription complex subunit 2.	0.996
Foxa1	Ar	G3I810	G3IGU9	Hepatocyte nuclear factor 3-alpha.	Androgen receptor.	0.745
Foxa1	I79_005864	G3I810	G3H6B0	Hepatocyte nuclear factor 3-alpha.	Histone-arginine methyltransferase CARM1.	0.538
Foxa1	I79_006792	G3I810	G3H8T1	Hepatocyte nuclear factor 3-alpha.	DUF1518 domain-containing protein.	0.460