(55 nodes) Tumor necrosis factor-mediated signaling pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Plvap	Plasmalemma vesicle-associated protein. (409 aa)
	I79_006506	Interferon-inducible protein AIM2. (352 aa)
	Ext1	Exostosin-1. (388 aa)
	I79_008225	CD70 antigen; Belongs to the tumor necrosis factor family. (221 aa)
	I79_008639	NF-kappa-B inhibitor alpha. (52 aa)
	I79_008640	NF-kappa-B inhibitor alpha. (90 aa)
	I79_008646	Thioredoxin domain-containing protein 17. (67 aa)
	Commd7	COMM domain-containing protein 7. (147 aa)
	I79_009066	Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (426 aa)
	Cldn18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	Tnfsf11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
	I79_010095	Inhibitor of nuclear factor kappa-B kinase subunit beta. (408 aa)
	I79_010646	LIM and senescent cell antigen-like-containing domain protein 3. (61 aa)
	Lims1	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (325 aa)
	I79_010752	Alpha-actinin-4. (327 aa)
	Actn4	Alpha-actinin-4. (234 aa)
	Traf3ip2	Adapter protein CIKS. (560 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	H671_3g9857	Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6. (124 aa)
	Cdip1	LITAF-like protein. (208 aa)
	I79_015555	Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (255 aa)
	Chuk	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (647 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Nfkbia	NF-kappa-B inhibitor alpha. (224 aa)
	I79_019374	LIM and senescent cell antigen-like-containing domain protein 1. (184 aa)
	I79_019425	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_025719	Tight junction protein ZO-2. (190 aa)
	I79_025481	Tight junction protein ZO-2. (294 aa)
	CgPICR_014038	LIM and senescent cell antigen-like-containing domain protein 1. (184 aa)
	I79_025142	Tight junction protein ZO-2. (464 aa)
	Umod	Uromodulin. (618 aa)
	Tnfrsf1b	Tumor necrosis factor receptor superfamily member 1B. (477 aa)
	Traf1	TNF receptor-associated factor 1. (298 aa)
	I79_023283	Ras-related GTP-binding protein A. (291 aa)
	Traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	Krt8	Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (488 aa)
	Krt18	Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (437 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	Rela	Transcription factor p65. (546 aa)
	Tnfrsf13c	Tumor necrosis factor receptor superfamily member 13C. (162 aa)
	Txndc17	Thioredoxin domain-containing protein 17. (176 aa)
	Card14	Caspase recruitment domain-containing protein 14. (961 aa)
	Eda2r	Tumor necrosis factor receptor superfamily member 27. (297 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (355 aa)
	I79_001029	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (277 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	I79_015063	Suppression of tumorigenicity protein 18. (780 aa)
	I79_015553	Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (131 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Traf5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	Pias3	E3 SUMO-protein ligase PIAS3. (619 aa)
	Traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Actn4	I79_010752	G3HJB1	G3HJB0	Alpha-actinin-4.	Alpha-actinin-4.	0.899
Card14	Traf3ip2	G3HTE7	G3HMS0	Caspase recruitment domain-containing protein 14.	Adapter protein CIKS.	0.422
CgPICR_014038	ilk	G3IN77	C0SSX9	LIM and senescent cell antigen-like-containing domain protein 1.	Integrin-linked protein kinase.	0.899
Chuk	Foxo3	G3HZA3	G3GXK7	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Forkhead box protein O3.	0.929
Chuk	I79_008639	G3HZA3	G3HDQ3	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor alpha.	0.927
Chuk	I79_008640	G3HZA3	G3HDQ4	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor alpha.	0.927
Chuk	I79_010095	G3HZA3	G3HHH8	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit beta.	0.989
Chuk	Nfkbia	G3HZA3	G3I3X5	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor alpha.	0.992
Chuk	Rela	G3HZA3	G3IDM9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Transcription factor p65.	0.992
Chuk	Stat1	G3HZA3	G3I9F9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Signal transducer and activator of transcription.	0.502
Chuk	Tnf	G3HZA3	G3HZG9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.965
Chuk	Tnfrsf1a	G3HZA3	G3GUL6	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Tumor necrosis factor receptor superfamily member 1A.	0.969
Chuk	Traf1	G3HZA3	G3IKM9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor 1.	0.722
Chuk	Traf2	G3HZA3	G3IHB5	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.983
Chuk	Traf3	G3HZA3	G3H369	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.809
Chuk	Traf5	G3HZA3	G3H2L5	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.958
Chuk	Traf6	G3HZA3	G3GZ05	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.990
Eda2r	Traf1	G3HTK6	G3IKM9	Tumor necrosis factor receptor superfamily member 27.	TNF receptor-associated factor 1.	0.458
Eda2r	Traf3	G3HTK6	G3H369	Tumor necrosis factor receptor superfamily member 27.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.954
Eda2r	Traf6	G3HTK6	G3GZ05	Tumor necrosis factor receptor superfamily member 27.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.973