(12 nodes) Leptin-mediated signaling pathway network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_015980	Leptin receptor. (533 aa)
	Ugcg	Ceramide glucosyltransferase. (236 aa)
	I79_000430	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (533 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Adipor1	Adiponectin receptor protein 1. (375 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Ebi3	Interleukin-27 subunit beta. (228 aa)
	I79_008980	Bardet-Biedl syndrome 4 protein-like. (104 aa)
	Bbs4	Bardet-Biedl syndrome 4 protein-like. (125 aa)
	I79_010469	Bardet-Biedl syndrome 2 protein-like. (594 aa)
	I79_010470	Metallothionein-3; Belongs to the metallothionein superfamily. Type 1 family. (108 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipor1	I79_015980	G3H3L5	G3HY62	Adiponectin receptor protein 1.	Leptin receptor.	0.410
Adipor1	Lep	G3H3L5	G3GZ86	Adiponectin receptor protein 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.705
Bbs4	I79_008980	G3HEJ7	G3HEJ6	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.450
Bbs4	I79_010469	G3HEJ7	G3HIJ8	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 2 protein-like.	0.947
I79_000430	I79_010469	G3GSB1	G3HIJ8	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.	Bardet-Biedl syndrome 2 protein-like.	0.424
I79_008980	Bbs4	G3HEJ6	G3HEJ7	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.450
I79_008980	I79_010469	G3HEJ6	G3HIJ8	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 2 protein-like.	0.947
I79_010469	Bbs4	G3HIJ8	G3HEJ7	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.947
I79_010469	I79_000430	G3HIJ8	G3GSB1	Bardet-Biedl syndrome 2 protein-like.	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.	0.424
I79_010469	I79_008980	G3HIJ8	G3HEJ6	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.947
I79_015980	Adipor1	G3HY62	G3H3L5	Leptin receptor.	Adiponectin receptor protein 1.	0.410
I79_015980	Lep	G3HY62	G3GZ86	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.992
I79_015980	Stat3	G3HY62	G3HLW9	Leptin receptor.	Signal transducer and activator of transcription.	0.739
Lep	Adipor1	G3GZ86	G3H3L5	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Adiponectin receptor protein 1.	0.705
Lep	I79_015980	G3GZ86	G3HY62	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Leptin receptor.	0.992
Lep	Sirt1	G3GZ86	G3HAB1	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	NAD-dependent deacetylase sirtuin-1.	0.487
Lep	Stat3	G3GZ86	G3HLW9	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Signal transducer and activator of transcription.	0.804
Sirt1	Lep	G3HAB1	G3GZ86	NAD-dependent deacetylase sirtuin-1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.487
Sirt1	Stat3	G3HAB1	G3HLW9	NAD-dependent deacetylase sirtuin-1.	Signal transducer and activator of transcription.	0.575
Stat3	I79_015980	G3HLW9	G3HY62	Signal transducer and activator of transcription.	Leptin receptor.	0.739