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Aldh1a2 Aldh1a2 cytb cytb I79_025795 I79_025795 Spp1 Spp1 Folr1 Folr1 Pitx2 Pitx2 Mthfr Mthfr NDOR1 NDOR1 Fes Fes Tyms Tyms Tpcn2 Tpcn2 I79_022311 I79_022311 I79_022023 I79_022023 Vdr Vdr Postn Postn Enpp1 Enpp1 Tgfb1 Tgfb1 Gas6 Gas6 Brip1 Brip1 Epo Epo I79_018785 I79_018785 Bche Bche Pth Pth I79_016240 I79_016240 F5 F5 I79_015930 I79_015930 Tspo Tspo Hlcs Hlcs I79_015616 I79_015616 Sod2 Sod2 Serpina7 Serpina7 I79_015207 I79_015207 I79_015065 I79_015065 Ccnd1 Ccnd1 I79_000568 I79_000568 CgPICR_003438 CgPICR_003438 Fgf23 Fgf23 Cd4 Cd4 Stc1 Stc1 Ptgs2 Ptgs2 Ogg1 Ogg1 Cat Cat Lep Lep Fkbp1b Fkbp1b I79_003765 I79_003765 Slc34a1 Slc34a1 I79_003959 I79_003959 Setdb1 Setdb1 Lrat Lrat Ascl1 Ascl1 Cdkn2d Cdkn2d Gpx1 Gpx1 Cd40 Cd40 I79_006978 I79_006978 Stc2 Stc2 I79_007641 I79_007641 Lrp6 Lrp6 Bmp7 Bmp7 Runx2 Runx2 I79_008941 I79_008941 Dcps Dcps Bglap Bglap Sfrp1 Sfrp1 PEMT PEMT Alad Alad Alpl Alpl Map1b Map1b Il15 Il15 Tshb Tshb Col1a1 Col1a1 I79_011076 I79_011076 Pim1 Pim1 Igf1r Igf1r Atp2b1 Atp2b1 I79_011367 I79_011367 Cbs Cbs I79_011643 I79_011643 I79_011644 I79_011644 Ada Ada Becn1 Becn1 Kl Kl I79_012903 I79_012903 I79_013067 I79_013067 Ppard Ppard PPARG PPARG I79_015041 I79_015041
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Aldh1a2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (460 aa)
cytbCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
I79_025795Vitamin D3 receptor. (86 aa)
Spp1Osteopontin. (117 aa)
Folr1Folate receptor alpha. (257 aa)
Pitx2Homeobox protein. (322 aa)
MthfrMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (644 aa)
NDOR1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (597 aa)
FesTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
TymsThymidylate synthase-like protein. (307 aa)
Tpcn2Two pore calcium channel protein 2. (338 aa)
I79_022311Two pore calcium channel protein 2. (227 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
VdrVitamin D3 receptor. (372 aa)
PostnPeriostin isoform 6. (785 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Gas6Growth arrest-specific protein 6. (684 aa)
Brip1Fanconi anemia group J protein-like. (1166 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
I79_018785Retinoic acid receptor alpha. (484 aa)
BcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
PthParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (114 aa)
I79_016240Beclin-1. (119 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2140 aa)
I79_015930Glutathione S-transferase theta-1; Belongs to the GST superfamily. (240 aa)
TspoTranslocator protein. (169 aa)
HlcsBiotin--protein ligase. (586 aa)
I79_015616Interferon-induced, double-stranded RNA-activated protein kinase. (180 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Serpina7Thyroxine-binding globulin; Belongs to the serpin family. (418 aa)
I79_01520725-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
I79_015065Kynureninase. (114 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
I79_000568Ornithine carbamoyltransferase, mitochondrial. (232 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Stc1Stanniocalcin-1. (247 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Ogg1N-glycosylase/DNA lyase. (335 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (555 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Fkbp1bPeptidylprolyl isomerase. (143 aa)
I79_003765Protein disulfide-isomerase A3. (444 aa)
Slc34a1Sodium-dependent phosphate transport protein 2A. (629 aa)
I79_003959Tripartite motif-containing protein 25. (1075 aa)
Setdb1Histone-lysine N-methyltransferase SETDB1. (1227 aa)
LratLecithin retinol acyltransferase-like protein. (227 aa)
Ascl1Achaete-scute-like 1. (140 aa)
Cdkn2dCyclin-dependent kinase 4 inhibitor D. (166 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
I79_006978Cytochrome P450 26A1; Belongs to the cytochrome P450 family. (379 aa)
Stc2Stanniocalcin-2. (297 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
DcpsScavenger mRNA-decapping enzyme DcpS. (339 aa)
BglapOsteocalcin; Binds strongly to apatite and calcium. (99 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (189 aa)
AladDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
AlplAlkaline phosphatase. (524 aa)
Map1bMicrotubule-associated protein 1B. (2371 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
TshbThyrotropin subunit beta-like protein. (138 aa)
Col1a1Collagen alpha-1(I) chain. (355 aa)
I79_011076Coagulation factor X. (629 aa)
Pim1Proto-oncogene serine/threonine-protein kinase Pim-1. (250 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Atp2b1Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (384 aa)
I79_011367Plasma membrane calcium-transporting ATPase 1. (327 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
I79_0116431,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (246 aa)
I79_0116441,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial. (177 aa)
AdaAdenosine deaminase. (363 aa)
Becn1Beclin-1. (448 aa)
KlKlotho. (900 aa)
I79_012903Pulmonary surfactant-associated protein A. (238 aa)
I79_013067Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (443 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015041Thymidylate synthase. (192 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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