(10 nodes) Leydig cell differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nr5a1	Steroidogenic factor 1. (462 aa)
	I79_022078	Homeobox protein Nkx-2.1. (190 aa)
	Ar	Androgen receptor. (517 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
	Tmf1	TATA element modulatory factor. (1094 aa)
	I79_006036	Sphingosine-1-phosphate lyase 1. (568 aa)
	Nr0b1	Nuclear receptor subfamily 0 group B member 1. (470 aa)
	Sf1	Splicing factor 1. (522 aa)
	I79_019286	Androgen receptor. (295 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	Ccnd1	G3IGU9	A5A422	Androgen receptor.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.692
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ccnd1	Ar	A5A422	G3IGU9	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Androgen receptor.	0.692
Ccnd1	I79_019286	A5A422	G3I705	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Androgen receptor.	0.690
I79_019286	Ar	G3I705	G3IGU9	Androgen receptor.	Androgen receptor.	0.915
I79_019286	Ccnd1	G3I705	A5A422	Androgen receptor.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.690
Nr0b1	Nr5a1	G3HXG4	G3I9D5	Nuclear receptor subfamily 0 group B member 1.	Steroidogenic factor 1.	0.992
Nr5a1	Nr0b1	G3I9D5	G3HXG4	Steroidogenic factor 1.	Nuclear receptor subfamily 0 group B member 1.	0.992