(46 nodes) Response to testosterone network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Hoxb13	Homeobox protein Hox-B13. (284 aa)
	I79_012135	Carbonic anhydrase 9. (114 aa)
	Ca9	Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (182 aa)
	Igf1r	Insulin-like growth factor 1 receptor. (191 aa)
	Rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	Thbs1	Thrombospondin-1. (533 aa)
	I79_005358	Estrogen receptor beta. (58 aa)
	Hoxd13	Homeobox protein Hox-D13. (204 aa)
	Edn1	Endothelin-1. (202 aa)
	Xrn1	5'-3' exoribonuclease 1. (1726 aa)
	Foxp1	Forkhead box protein P1. (696 aa)
	I79_000024	Aldo-keto reductase family 1 member C18. (219 aa)
	Hoxa11	Homeobox protein Hox-A11. (250 aa)
	I79_008458	Homeobox protein Hox-A10. (117 aa)
	Hoxa9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (271 aa)
	Cacna1a	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (78 aa)
	Calr	Calreticulin. (417 aa)
	Srd5a1	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
	Gba	Glucosylceramidase. (515 aa)
	I79_007624	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	I79_025512	Urotensin-2. (88 aa)
	I79_025333	Alcohol dehydrogenase 1. (220 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	Cacna1b	Voltage-dependent N-type calcium channel subunit alpha-1B. (244 aa)
	Calhm4	Protein FAM26D. (519 aa)
	Psph	Phosphoserine phosphatase. (250 aa)
	Rnf4	RING finger protein 4. (128 aa)
	Nqo1	NAD(P)H dehydrogenase [quinone] 1. (274 aa)
	Msn	Moesin. (293 aa)
	Tspo	Translocator protein. (169 aa)
	Elk1	ETS domain-containing protein Elk-1. (425 aa)
	I79_015356	Heat shock factor protein 1. (524 aa)
	I79_015205	Cell division protein kinase 4; Belongs to the protein kinase superfamily. (367 aa)
	Cflar	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (484 aa)
	Tbxa2r	Thromboxane A2 receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	CgPICR_018825	Cell division protein kinase 4. (121 aa)
	Hmgcs2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	I79_019286	Androgen receptor. (295 aa)
	I79_022371	Cell division protein kinase 4. (143 aa)
	I79_023022	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (218 aa)
	Ar	Androgen receptor. (517 aa)
	I79_023559	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1496 aa)
	Mstn	Growth/differentiation factor 8. (295 aa)
	Spp1	Osteopontin. (117 aa)
	I79_025230	Alcohol dehydrogenase 1. (331 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ar	Calr	G3IGU9	G3HCX8	Androgen receptor.	Calreticulin.	0.456
Ar	I79_005358	G3IGU9	G3H4Z4	Androgen receptor.	Estrogen receptor beta.	0.597
Ar	I79_019286	G3IGU9	G3I705	Androgen receptor.	Androgen receptor.	0.915
Ar	Igf1r	G3IGU9	G3HKI5	Androgen receptor.	Insulin-like growth factor 1 receptor.	0.527
Ar	Srd5a1	G3IGU9	G3HC96	Androgen receptor.	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.526
Cacna1a	Cacna1b	G3HCZ1	G3I5Z3	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent N-type calcium channel subunit alpha-1B.	0.900
Cacna1a	I79_023559	G3HCZ1	G3II91	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.871
Cacna1b	Cacna1a	G3I5Z3	G3HCZ1	Voltage-dependent N-type calcium channel subunit alpha-1B.	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	0.900
Cacna1b	I79_023559	G3I5Z3	G3II91	Voltage-dependent N-type calcium channel subunit alpha-1B.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.403
Calr	Ar	G3HCX8	G3IGU9	Calreticulin.	Androgen receptor.	0.456
Calr	I79_019286	G3HCX8	G3I705	Calreticulin.	Androgen receptor.	0.456
Calr	Thbs1	G3HCX8	G3HHV4	Calreticulin.	Thrombospondin-1.	0.666
CgPICR_018825	Myc	G3HQ42	G3IP28	Cell division protein kinase 4.	Myc proto-oncogene protein.	0.430
Edn1	I79_025512	G3H0G9	G3INI7	Endothelin-1.	Urotensin-2.	0.627
Edn1	Spp1	G3H0G9	G3IKQ9	Endothelin-1.	Osteopontin.	0.476
Hoxa11	Hoxa9	G3HD82	G3HD80	Homeobox protein Hox-A11.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.422
Hoxa11	I79_008458	G3HD82	G3HD81	Homeobox protein Hox-A11.	Homeobox protein Hox-A10.	0.507
Hoxa9	Hoxa11	G3HD80	G3HD82	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox protein Hox-A11.	0.422
Hoxa9	I79_008458	G3HD80	G3HD81	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox protein Hox-A10.	0.900
I79_005358	Ar	G3H4Z4	G3IGU9	Estrogen receptor beta.	Androgen receptor.	0.597