STRINGSTRING
Il18 Il18 I79_007336 I79_007336 I79_007624 I79_007624 I79_007641 I79_007641 Lrp6 Lrp6 I79_008932 I79_008932 I79_008941 I79_008941 Cldn18 Cldn18 Itgb3 Itgb3 Tnfsf11 Tnfsf11 I79_010073 I79_010073 Sfrp1 Sfrp1 Tmem119 Tmem119 Syk Syk Cartpt Cartpt I79_010693 I79_010693 Fgfr3 Fgfr3 Mc4r Mc4r Bcr Bcr I79_012556 I79_012556 Ddr2 Ddr2 Ppargc1b Ppargc1b I79_013650 I79_013650 I79_013659 I79_013659 I79_013771 I79_013771 I79_013797 I79_013797 I79_014111 I79_014111 Pdk4 Pdk4 Abr Abr I79_014743 I79_014743 I79_014943 I79_014943 PPARG PPARG Gja1 Gja1 FSHB FSHB I79_025002 I79_025002 Spp1 Spp1 Inpp5d Inpp5d Csk Csk I79_023475 I79_023475 I79_023010 I79_023010 S1pr1 S1pr1 I79_022663 I79_022663 I79_022515 I79_022515 Tmbim1 Tmbim1 Grem1 Grem1 Plekhm1 Plekhm1 Adam8 Adam8 Gpr137 Gpr137 I79_019107 I79_019107 I79_018885 I79_018885 Dlk1 Dlk1 I79_016800 I79_016800 H671_4g12667 H671_4g12667 I79_015980 I79_015980 I79_015624 I79_015624 Gpr137b Gpr137b Lrp1 Lrp1 Gpnmb Gpnmb I79_015109 I79_015109 Klf6 Klf6 Def8 Def8 Tfrc Tfrc I79_001046 I79_001046 I79_001981 I79_001981 Agt Agt Src Src Mdk Mdk Lep Lep I79_003225 I79_003225 Suco Suco I79_004285 I79_004285 I79_004475 I79_004475
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
I79_007336Tumor necrosis factor receptor superfamily member 11B. (323 aa)
I79_007624Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
I79_008932Alpha-L-iduronidase. (625 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
Cldn18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Tmem119Transmembrane protein 119. (277 aa)
SykTyrosine-protein kinase. (611 aa)
CartptCocaine-and amphetamine-regulated transcript protein. (112 aa)
I79_010693Type II inositol-3,4-bisphosphate 4-phosphatase. (491 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Mc4rMelanocortin receptor 4. (332 aa)
BcrBreakpoint cluster region protein. (1193 aa)
I79_012556Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
Ddr2Discoidin domain-containing receptor 2. (854 aa)
Ppargc1bPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (843 aa)
I79_013650Peroxisome proliferator-activated receptor gamma coactivator 1-beta. (111 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
I79_013771Calcitonin. (206 aa)
I79_013797Target of Nesh-SH3. (335 aa)
I79_014111Protein-serine/threonine kinase. (60 aa)
Pdk4Protein-serine/threonine kinase. (178 aa)
AbrActive breakpoint cluster region-related protein. (769 aa)
I79_014743Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
I79_014943Transmembrane 7 superfamily member 4. (243 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
FSHBFollicle stimulating hormone beta-subunit protein. (129 aa)
I79_025002Ubiquitin-associated and SH3 domain-containing protein B. (201 aa)
Spp1Osteopontin. (117 aa)
Inpp5dPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
CskTyrosine-protein kinase. (450 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
I79_023010Latent-transforming growth factor beta-binding protein 3. (624 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
I79_022663Ubiquitin-associated and SH3 domain-containing protein B. (85 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
Tmbim1Transmembrane BAX inhibitor motif-containing protein 1; Belongs to the BI1 family. (308 aa)
Grem1Gremlin-1. (117 aa)
Plekhm1Pleckstrin-likey domain-containing family M member 1. (1062 aa)
Adam8Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
Gpr137Integral membrane protein GPR137. (265 aa)
I79_019107Integral membrane protein GPR137C. (89 aa)
I79_018885Transmembrane protein 64. (105 aa)
Dlk1Protein delta-like 1. (361 aa)
I79_016800Cytochrome P450 19A1; Belongs to the cytochrome P450 family. (436 aa)
H671_4g12667Alpha-2-HS-glycoprotein. (333 aa)
I79_015980Leptin receptor. (533 aa)
I79_015624Thrombospondin-4. (960 aa)
Gpr137bIntegral membrane protein GPR137B. (385 aa)
Lrp1Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
GpnmbTransmembrane glycoprotein NMB. (610 aa)
I79_015109Interleukin-6. (174 aa)
Klf6Krueppel-like factor 6. (317 aa)
Def8Differentially expressed in FDCP 8-like. (451 aa)
TfrcTransferrin receptor protein 1. (757 aa)
I79_001046Neurofibromin. (2164 aa)
I79_001981Interleukin-20 receptor alpha chain. (479 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
SrcTyrosine-protein kinase. (536 aa)
MdkMidkine. (160 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_003225Serotransferrin. (1227 aa)
SucoProtein C1orf9-like. (1150 aa)
I79_004285p2X purinoceptor 7. (805 aa)
I79_004475Carbonic anhydrase 2. (220 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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