(21 nodes) Toll-like receptor 4 signaling pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nmi	N-myc-interactor. (303 aa)
	Ticam2	TIR domain-containing adapter molecule 2. (233 aa)
	I79_014126	Leucine-rich repeat flightless-interacting protein 2. (455 aa)
	I79_014088	TNFAIP3-interacting protein 3. (113 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	I79_009350	Toll/interleukin-1 receptor domain-containing adapter protein. (245 aa)
	I79_008640	NF-kappa-B inhibitor alpha. (90 aa)
	I79_008639	NF-kappa-B inhibitor alpha. (52 aa)
	Tril	Leucine-rich repeat-containing protein KIAA0644. (437 aa)
	S100a14	Protein S100-A14; Belongs to the S-100 family. (104 aa)
	Rab11fip2	Rab11 family-interacting protein 2. (452 aa)
	Pik3ap1	Phosphoinositide 3-kinase adapter protein 1. (61 aa)
	Prkce	Protein kinase C epsilon type. (137 aa)
	I79_001592	Protein kinase C epsilon type. (163 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	Nfkbia	NF-kappa-B inhibitor alpha. (224 aa)
	Cd14	Monocyte differentiation antigen CD14. (309 aa)
	I79_014546	Leucine-rich repeat transmembrane protein FLRT1. (354 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd14	Tlr4	G3I590	G3I192	Monocyte differentiation antigen CD14.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.982
I79_001592	Prkce	G3GV61	G3GV62	Protein kinase C epsilon type.	Protein kinase C epsilon type.	0.742
I79_008639	Irak1	G3HDQ3	G3HSV4	NF-kappa-B inhibitor alpha.	Interleukin-1 receptor-associated kinase 1.	0.544
I79_008640	Irak1	G3HDQ4	G3HSV4	NF-kappa-B inhibitor alpha.	Interleukin-1 receptor-associated kinase 1.	0.544
I79_009350	Irak1	G3HFJ2	G3HSV4	Toll/interleukin-1 receptor domain-containing adapter protein.	Interleukin-1 receptor-associated kinase 1.	0.736
I79_009350	Ticam2	G3HFJ2	G3HTM6	Toll/interleukin-1 receptor domain-containing adapter protein.	TIR domain-containing adapter molecule 2.	0.591
I79_009350	Tlr4	G3HFJ2	G3I192	Toll/interleukin-1 receptor domain-containing adapter protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.879
Irak1	I79_008639	G3HSV4	G3HDQ3	Interleukin-1 receptor-associated kinase 1.	NF-kappa-B inhibitor alpha.	0.544
Irak1	I79_008640	G3HSV4	G3HDQ4	Interleukin-1 receptor-associated kinase 1.	NF-kappa-B inhibitor alpha.	0.544
Irak1	I79_009350	G3HSV4	G3HFJ2	Interleukin-1 receptor-associated kinase 1.	Toll/interleukin-1 receptor domain-containing adapter protein.	0.736
Irak1	Nfkbia	G3HSV4	G3I3X5	Interleukin-1 receptor-associated kinase 1.	NF-kappa-B inhibitor alpha.	0.544
Irak1	Ripk2	G3HSV4	G3HP95	Interleukin-1 receptor-associated kinase 1.	Receptor-interacting serine/threonine-protein kinase 2.	0.496
Irak1	Ticam2	G3HSV4	G3HTM6	Interleukin-1 receptor-associated kinase 1.	TIR domain-containing adapter molecule 2.	0.648
Irak1	Tlr4	G3HSV4	G3I192	Interleukin-1 receptor-associated kinase 1.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.871
Nfkbia	Irak1	G3I3X5	G3HSV4	NF-kappa-B inhibitor alpha.	Interleukin-1 receptor-associated kinase 1.	0.544
Prkce	I79_001592	G3GV62	G3GV61	Protein kinase C epsilon type.	Protein kinase C epsilon type.	0.742
Ripk2	Irak1	G3HP95	G3HSV4	Receptor-interacting serine/threonine-protein kinase 2.	Interleukin-1 receptor-associated kinase 1.	0.496
Ripk2	Ticam2	G3HP95	G3HTM6	Receptor-interacting serine/threonine-protein kinase 2.	TIR domain-containing adapter molecule 2.	0.425
Ripk2	Tlr4	G3HP95	G3I192	Receptor-interacting serine/threonine-protein kinase 2.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.551
Ticam2	I79_009350	G3HTM6	G3HFJ2	TIR domain-containing adapter molecule 2.	Toll/interleukin-1 receptor domain-containing adapter protein.	0.591