STRINGSTRING
I79_016874 I79_016874 Apoh Apoh Pdcd4 Pdcd4 Ccdc142 Ccdc142 Atf4 Atf4 I79_005895 I79_005895 Slc7a5 Slc7a5 E2f3 E2f3 I79_002785 I79_002785 Map2k4 Map2k4 Edn1 Edn1 Rbm10 Rbm10 Igf1 Igf1 Dnmt1 Dnmt1 I79_007067 I79_007067 Sirt1 Sirt1 Gsk3b Gsk3b I79_007641 I79_007641 Lrp6 Lrp6 IL12B IL12B Stk4 Stk4 I79_012750 I79_012750 PPARG PPARG Sod2 Sod2 Mfn2 Mfn2 Arrb1 Arrb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_016874Cyclin-dependent kinase inhibitor 2A, isoforms 1/2. (92 aa)
ApohBeta-2-glycoprotein 1. (577 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
Ccdc142Coiled-coil domain-containing protein 142. (723 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
I79_005895DNA (Cytosine-5)-methyltransferase 1. (85 aa)
Slc7a5Large neutral amino acids transporter small subunit 1. (506 aa)
E2f3Transcription factor E2F3. (458 aa)
I79_002785Beta-arrestin-2. (65 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (342 aa)
Edn1Endothelin-1. (202 aa)
Rbm10RNA-binding protein 10. (1001 aa)
Igf1Insulin-like growth factor I. (75 aa)
Dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1494 aa)
I79_007067Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1107 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Stk4Serine/threonine-protein kinase 4. (487 aa)
I79_012750Glutamate receptor 4. (545 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Arrb1Beta-arrestin-1. (422 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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