(35 nodes) Response to fluid shear stress network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	Tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	Abca1	ATP-binding cassette sub-family A member 1. (2261 aa)
	I79_001733	Mitogen-activated protein kinase. (1186 aa)
	Ptgs2	Prostaglandin G/H synthase 2. (604 aa)
	Tfpi2	Tissue factor pathway inhibitor. (222 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Mmp2	72 kDa type IV collagenase. (662 aa)
	Nfe2l2	Nuclear factor erythroid 2-related factor 2. (588 aa)
	I79_004285	p2X purinoceptor 7. (805 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	I79_006693	Intraflagellar transport protein 88-like. (533 aa)
	I79_006745	Mothers against decapentaplegic-like 6. (71 aa)
	Smad6	Mothers against decapentaplegic-like 6. (174 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Pkd1	Polycystin-1. (3717 aa)
	Hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	Xbp1	X-box binding protein 1 isoform 1. (330 aa)
	Smad7	Mothers against decapentaplegic-like 7. (256 aa)
	I79_013660	Beta-type platelet-derived growth factor receptor. (454 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	Socs5	Suppressor of cytokine signaling 5. (530 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Klf4	Krueppel-like factor 4. (474 aa)
	I79_022055	Argininosuccinate synthase. (97 aa)
	Spp1	Osteopontin. (117 aa)
	I79_024483	Polycystin-2. (192 aa)
	Mtss1	Metastasis suppressor protein 1. (526 aa)
	Ass1	Argininosuccinate synthase. (242 aa)
	I79_025625	Polycystin-2. (318 aa)
	Has2	Hyaluronan synthase 2. (337 aa)
	I79_025944	Hyaluronan synthase 2. (151 aa)
	I79_025974	Metastasis suppressor protein 1. (73 aa)
	Gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Gja1	G3H397	Q80Z93	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.413
Akt1	I79_007693	G3H397	G3HB72	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.835
Akt1	Klf4	G3H397	G3IAC9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Krueppel-like factor 4.	0.497
Akt1	Mmp2	G3H397	G3H0R8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	72 kDa type IV collagenase.	0.535
Akt1	Nfe2l2	G3H397	G3H1T9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 2.	0.717
Akt1	Ptgs2	G3H397	G3GWV6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Prostaglandin G/H synthase 2.	0.434
Akt1	Smad7	G3H397	G3HQJ4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic-like 7.	0.465
Akt1	Src	G3H397	G3GXX7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.857
Akt1	Tgfb1	G3H397	G3IA12	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta-1.	0.589
Akt1	Xbp1	G3H397	G3HNZ9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	X-box binding protein 1 isoform 1.	0.405
Ass1	I79_007693	G3IMU3	G3HB72	Argininosuccinate synthase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.419
Ass1	I79_022055	G3IMU3	G3IEB0	Argininosuccinate synthase.	Argininosuccinate synthase.	0.951
Gja1	Akt1	Q80Z93	G3H397	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.413
Gja1	Src	Q80Z93	G3GXX7	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Tyrosine-protein kinase.	0.857
Has2	I79_006693	G3IPF7	G3H8J1	Hyaluronan synthase 2.	Intraflagellar transport protein 88-like.	0.448
Has2	I79_025944	G3IPF7	G3IPM5	Hyaluronan synthase 2.	Hyaluronan synthase 2.	0.949
Has2	Ptgs2	G3IPF7	G3GWV6	Hyaluronan synthase 2.	Prostaglandin G/H synthase 2.	0.478
Hdac5	I79_006693	G3HLJ3	G3H8J1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Intraflagellar transport protein 88-like.	0.418
Hdac5	Mef2c	G3HLJ3	G3HAW1	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Myocyte-specific enhancer factor 2C.	0.795
I79_001733	Mef2c	G3GVJ3	G3HAW1	Mitogen-activated protein kinase.	Myocyte-specific enhancer factor 2C.	0.665