(27 nodes) Response to prostaglandin network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

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Your Input:
	Tnfsf4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
	Prkce	Protein kinase C epsilon type. (137 aa)
	I79_001592	Protein kinase C epsilon type. (163 aa)
	I79_000983	Non-specific serine/threonine protein kinase. (747 aa)
	P2ry6	p2Y purinoceptor 6. (328 aa)
	I79_021198	Acetyl-CoA carboxylase 1. (231 aa)
	I79_020666	Prostaglandin D2 receptor. (337 aa)
	Ptger2	Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	Adcy6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	Fn1	Fibronectin. (2486 aa)
	P2ry4	p2Y purinoceptor 4-like protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	I79_015207	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Hmgcs2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Ccl21	C-C motif chemokine 21a. (148 aa)
	Akap8	A-kinase anchor protein 8; Belongs to the AKAP95 family. (690 aa)
	I79_010910	Neurabin-2. (631 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	I79_010073	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
	Prkaa1	Non-specific serine/threonine protein kinase. (477 aa)
	Tgfbr3	TGF-beta receptor type III. (849 aa)
	I79_006999	Acetyl-CoA carboxylase 1. (1579 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Edn1	Endothelin-1. (202 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	I79_003342	Apolipoprotein B-100. (946 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adcy6	Akt1	G3I6K2	G3H397	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.695
Akt1	Adcy6	G3H397	G3I6K2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.695
Akt1	Edn1	G3H397	G3H0G9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Endothelin-1.	0.412
Akt1	I79_000983	G3H397	G3GTJ7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.430
Akt1	PPARG	G3H397	G3HVG0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.541
Akt1	Prkaa1	G3H397	G3HHG7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.464
Apob	I79_003342	G3GZQ0	G3GZP9	Apolipoprotein B-100.	Apolipoprotein B-100.	0.943
Apob	PPARG	G3GZQ0	G3HVG0	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.584
Ccl19	Ccl21	G3HN20	G3HN19	C-C motif chemokine.	C-C motif chemokine 21a.	0.990
Ccl21	Ccl19	G3HN19	G3HN20	C-C motif chemokine 21a.	C-C motif chemokine.	0.990
Edn1	Akt1	G3H0G9	G3H397	Endothelin-1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.412
Edn1	PPARG	G3H0G9	G3HVG0	Endothelin-1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.519
Hmgcs2	PPARG	G3HP76	G3HVG0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.426
I79_000983	Akt1	G3GTJ7	G3H397	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.430
I79_000983	Prkaa1	G3GTJ7	G3HHG7	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.736
I79_001592	Prkce	G3GV61	G3GV62	Protein kinase C epsilon type.	Protein kinase C epsilon type.	0.742
I79_003342	Apob	G3GZP9	G3GZQ0	Apolipoprotein B-100.	Apolipoprotein B-100.	0.943
I79_006999	I79_021198	G3H9D1	G3IC10	Acetyl-CoA carboxylase 1.	Acetyl-CoA carboxylase 1.	0.927
I79_006999	PPARG	G3H9D1	G3HVG0	Acetyl-CoA carboxylase 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.409
I79_010073	Ptger2	G3HHH1	G3IAN9	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family.	0.653