(35 nodes) Embryonic hindlimb morphogenesis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_012814	Chromodomain-helicase-DNA-binding protein 7. (100 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	Tbx3	T-box transcription factor TBX3. (709 aa)
	Msx1	Homeobox protein MSX-1. (261 aa)
	I79_002219	Neuroendocrine secretory protein 55. (295 aa)
	Rpgrip1l	Protein fantom. (1265 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	I79_005213	Nuclear receptor domain-containing protein. (162 aa)
	Rarb	Retinoic acid receptor beta. (284 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	Smarca4	Putative global transcription activator SNF2L4. (1614 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Tbx4	T-box transcription factor TBX4. (688 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	Osr1	Protein odd-skipped-related 1. (266 aa)
	I79_009708	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (332 aa)
	I79_010112	AF4/FMR2 family member 3. (286 aa)
	Aff3	AF4/FMR2 family member 3. (766 aa)
	I79_010314	Ecotropic virus integration site 1 protein. (947 aa)
	Wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
	Pitx2	Homeobox protein. (322 aa)
	Alx3	Homeobox protein aristaless-like 3. (200 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
	I79_017450	Zinc finger and BTB domain-containing protein 16. (236 aa)
	Zbtb16	Zinc finger and BTB domain-containing protein 16. (423 aa)
	Dicer1	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Alx4	Homeobox protein aristaless-like 4. (237 aa)
	Rarg	Retinoic acid receptor gamma. (458 aa)
	Chd7	Chromodomain-helicase-DNA-binding protein 7. (615 aa)
	I79_012815	Chromodomain-helicase-DNA-binding protein 7. (150 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aff3	I79_010112	G3HHK9	G3HHK8	AF4/FMR2 family member 3.	AF4/FMR2 family member 3.	0.940
Chd7	Ctnnb1	G3HPU6	G3H996	Chromodomain-helicase-DNA-binding protein 7.	Catenin beta-1.	0.521
Chd7	I79_012814	G3HPU6	G3HPU4	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.886
Chd7	I79_012815	G3HPU6	G3HPU5	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.845
Ctnnb1	Chd7	G3H996	G3HPU6	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_006254	G3H996	G3H7C4	Catenin beta-1.	Bone morphogenetic protein 4.	0.448
Ctnnb1	I79_007641	G3H996	G3HB26	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	I79_012814	G3H996	G3HPU4	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	I79_012815	G3H996	G3HPU5	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	Lrp6	G3H996	G3HB27	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	Pitx2	G3H996	G3IHV5	Catenin beta-1.	Homeobox protein.	0.693
Ctnnb1	Smarca4	G3H996	G3H6A7	Catenin beta-1.	Putative global transcription activator SNF2L4.	0.843
Ctnnb1	Tbx4	G3H996	G3H9F0	Catenin beta-1.	T-box transcription factor TBX4.	0.470
Ctnnb1	Wnt7a	G3H996	G3GS11	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.536
Dicer1	Med1	G3HZ70	G3H5X2	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.416
Fgf4	I79_006254	G3I4D8	G3H7C4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.483
Fgf4	I79_019149	G3I4D8	G3I6M4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518
Fgf4	Msx1	G3I4D8	G3GWE2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein MSX-1.	0.410
Fgf4	Npm3	G3I4D8	G3HXU8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518