(43 nodes) Forelimb morphogenesis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fmn1	Formin-1. (644 aa)
	I79_010314	Ecotropic virus integration site 1 protein. (947 aa)
	I79_010137	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (262 aa)
	I79_009364	Transcription factor AP-2 alpha. (411 aa)
	Osr1	Protein odd-skipped-related 1. (266 aa)
	Hoxa11	Homeobox protein Hox-A11. (250 aa)
	Hoxa9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (271 aa)
	I79_008277	Sal-like protein 3. (1161 aa)
	Runx2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	I79_007514	Growth/differentiation factor 5. (253 aa)
	Rnf165	RING finger protein 165. (280 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	I79_006562	Voltage-dependent L-type calcium channel subunit alpha-1C. (1112 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	Lnpk	Protein lunapark. (350 aa)
	Hoxd4	Homeobox protein Hox-D10. (371 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Rpgrip1l	Protein fantom. (1265 aa)
	Msx1	Homeobox protein MSX-1. (261 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	Tbx3	T-box transcription factor TBX3. (709 aa)
	Tbx5	T-box transcription factor TBX5. (518 aa)
	Tp63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (642 aa)
	Wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
	Aldh1a2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (460 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	Alx3	Homeobox protein aristaless-like 3. (200 aa)
	Reck	Reversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
	I79_020843	Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
	Enpp1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
	I79_017450	Zinc finger and BTB domain-containing protein 16. (236 aa)
	Zbtb16	Zinc finger and BTB domain-containing protein 16. (423 aa)
	I79_016814	Short stature homeobox protein 2. (194 aa)
	Rdh10	Retinol dehydrogenase 10. (65 aa)
	Alx4	Homeobox protein aristaless-like 4. (237 aa)
	Ift122	Intraflagellar transport protein 122-like. (292 aa)
	I79_012894	Transcription factor AP-2 beta. (287 aa)
	Magt1	Transcriptional regulator ATRX. (2344 aa)
	Nipbl	Nipped-B-like protein. (104 aa)
	I79_010448	Formin-1. (1049 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aldh1a2	Rdh10	G3GRL9	G3HX35	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 10.	0.952
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_007641	G3H996	G3HB26	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	I79_010137	G3H996	G3HHN3	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.484
Ctnnb1	Lrp6	G3H996	G3HB27	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	Runx2	G3H996	G3HC75	Catenin beta-1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.617
Ctnnb1	Tbx5	G3H996	G3GU42	Catenin beta-1.	T-box transcription factor TBX5.	0.713
Ctnnb1	Wnt7a	G3H996	G3GS11	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.536
Fmn1	I79_010448	G3HIH7	G3HIH8	Formin-1.	Formin-1.	0.666
Hoxa11	Hoxa9	G3HD82	G3HD80	Homeobox protein Hox-A11.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.422
Hoxa11	Hoxd4	G3HD82	G3H1U6	Homeobox protein Hox-A11.	Homeobox protein Hox-D10.	0.475
Hoxa9	Hoxa11	G3HD80	G3HD82	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox protein Hox-A11.	0.422
Hoxd4	Hoxa11	G3H1U6	G3HD82	Homeobox protein Hox-D10.	Homeobox protein Hox-A11.	0.475
I79_006225	Ctnnb1	G3H796	G3H996	Sonic hedgehog protein.	Catenin beta-1.	0.553
I79_006225	Msx1	G3H796	G3GWE2	Sonic hedgehog protein.	Homeobox protein MSX-1.	0.694
I79_006562	Ift122	G3H863	G3HVL8	Voltage-dependent L-type calcium channel subunit alpha-1C.	Intraflagellar transport protein 122-like.	0.579
I79_007641	Ctnnb1	G3HB26	G3H996	Low-density lipoprotein receptor-related protein 6.	Catenin beta-1.	0.686
I79_007641	Wnt7a	G3HB26	G3GS11	Low-density lipoprotein receptor-related protein 6.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.604
I79_009364	I79_012894	G3HFK4	G3HQ06	Transcription factor AP-2 alpha.	Transcription factor AP-2 beta.	0.737
I79_009364	Msx1	G3HFK4	G3GWE2	Transcription factor AP-2 alpha.	Homeobox protein MSX-1.	0.512