(27 nodes) Embryonic hemopoiesis network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	Thoc5	THO complex subunit 5-like. (683 aa)
	Pbx1	Pre-B-cell leukemia transcription factor 1. (325 aa)
	Stk4	Serine/threonine-protein kinase 4. (487 aa)
	Gata1	Erythroid transcription factor-like protein. (330 aa)
	Runx1	Runt-related transcription factor 1. (462 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	I79_014483	Serine/threonine-protein kinase 3. (118 aa)
	Atf4	Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	Flt3lg	SL cytokine. (230 aa)
	Kmt2a	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3512 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	I79_023161	Alanine--glyoxylate aminotransferase 2-like 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	I79_000238	Zinc finger protein ZFPM1. (744 aa)
	Tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	Tal1	T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
	Lmo2	Rhombotin-2. (151 aa)
	Sh2b3	SH2B adapter protein 3. (364 aa)
	I79_004353	Alanine--glyoxylate aminotransferase 2-like 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	I79_007806	Thyroid peroxidase. (841 aa)
	Klf1	Krueppel-like factor 1. (356 aa)
	Kat6a	Histone acetyltransferase MYST3. (200 aa)
	Kitlg	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	Stk3	Serine/threonine-protein kinase 3. (260 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Flt3lg	Kit	G3I001	G3IMP9	SL cytokine.	Mast/stem cell growth factor receptor.	0.868
Flt3lg	Kitlg	G3I001	G3HII0	SL cytokine.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.675
Flt3lg	Med1	G3I001	G3H5X2	SL cytokine.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.752
Gata1	Gata3	G3HND3	G3GR59	Erythroid transcription factor-like protein.	Trans-acting T-cell-specific transcription factor GATA-3.	0.544
Gata1	I79_000238	G3HND3	G3GRU4	Erythroid transcription factor-like protein.	Zinc finger protein ZFPM1.	0.940
Gata1	Kitlg	G3HND3	G3HII0	Erythroid transcription factor-like protein.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.421
Gata1	Klf1	G3HND3	G3HCX4	Erythroid transcription factor-like protein.	Krueppel-like factor 1.	0.892
Gata1	Kmt2a	G3HND3	G3I5S4	Erythroid transcription factor-like protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.481
Gata1	Lmo2	G3HND3	G3GYY1	Erythroid transcription factor-like protein.	Rhombotin-2.	0.991
Gata1	Med1	G3HND3	G3H5X2	Erythroid transcription factor-like protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.469
Gata1	Runx1	G3HND3	G3HNW1	Erythroid transcription factor-like protein.	Runt-related transcription factor 1.	0.820
Gata1	Tal1	G3HND3	G3GYT5	Erythroid transcription factor-like protein.	T-cell acute lymphocytic leukemia protein 1-like.	0.977
Gata3	Gata1	G3GR59	G3HND3	Trans-acting T-cell-specific transcription factor GATA-3.	Erythroid transcription factor-like protein.	0.544
Gata3	I79_000238	G3GR59	G3GRU4	Trans-acting T-cell-specific transcription factor GATA-3.	Zinc finger protein ZFPM1.	0.707
Gata3	Lmo2	G3GR59	G3GYY1	Trans-acting T-cell-specific transcription factor GATA-3.	Rhombotin-2.	0.692
Gata3	Runx1	G3GR59	G3HNW1	Trans-acting T-cell-specific transcription factor GATA-3.	Runt-related transcription factor 1.	0.780
Gata3	Tal1	G3GR59	G3GYT5	Trans-acting T-cell-specific transcription factor GATA-3.	T-cell acute lymphocytic leukemia protein 1-like.	0.885
Hif1a	I79_022034	G3HZ04	G3IE90	Hypoxia-inducible factor 1 alpha.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.489
Hif1a	Runx1	G3HZ04	G3HNW1	Hypoxia-inducible factor 1 alpha.	Runt-related transcription factor 1.	0.507
I79_000238	Gata1	G3GRU4	G3HND3	Zinc finger protein ZFPM1.	Erythroid transcription factor-like protein.	0.940