(17 nodes) Hippo signaling network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Lats1	Serine/threonine-protein kinase LATS1. (1130 aa)
	I79_024087	Transcriptional enhancer factor TEF-4. (198 aa)
	Sav1	Protein salvador-like 1. (210 aa)
	I79_021721	Protocadherin-16. (3015 aa)
	I79_018283	Mps one binder kinase activator-like 1B. (72 aa)
	Fat4	Protocadherin Fat 4. (5152 aa)
	I79_016660	Transcriptional enhancer factor TEF-4. (375 aa)
	Tead3	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (373 aa)
	Wwtr1	WW domain-containing transcription regulator protein 1. (395 aa)
	Tead1	Transcriptional enhancer factor TEF-1. (432 aa)
	I79_014483	Serine/threonine-protein kinase 3. (118 aa)
	Stk4	Serine/threonine-protein kinase 4. (487 aa)
	Stk3	Serine/threonine-protein kinase 3. (260 aa)
	Lats2	Serine/threonine-protein kinase LATS2. (1040 aa)
	Tead4	Transcriptional enhancer factor TEF-3. (361 aa)
	Pja2	E3 ubiquitin-protein ligase Praja2. (699 aa)
	I79_001484	65 kDa Yes-associated protein. (257 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I79_001484	I79_014483	G3GUW0	G3HU75	65 kDa Yes-associated protein.	Serine/threonine-protein kinase 3.	0.749
I79_001484	I79_016660	G3GUW0	G3HZZ5	65 kDa Yes-associated protein.	Transcriptional enhancer factor TEF-4.	0.861
I79_001484	I79_018283	G3GUW0	G3I4A6	65 kDa Yes-associated protein.	Mps one binder kinase activator-like 1B.	0.758
I79_001484	I79_024087	G3GUW0	G3IJQ1	65 kDa Yes-associated protein.	Transcriptional enhancer factor TEF-4.	0.861
I79_001484	Lats1	G3GUW0	G3H3S6	65 kDa Yes-associated protein.	Serine/threonine-protein kinase LATS1.	0.925
I79_001484	Lats2	G3GUW0	G3H8I4	65 kDa Yes-associated protein.	Serine/threonine-protein kinase LATS2.	0.898
I79_001484	Sav1	G3GUW0	G3IDP2	65 kDa Yes-associated protein.	Protein salvador-like 1.	0.798
I79_001484	Stk3	G3GUW0	G3HK46	65 kDa Yes-associated protein.	Serine/threonine-protein kinase 3.	0.749
I79_001484	Stk4	G3GUW0	G3HLS6	65 kDa Yes-associated protein.	Serine/threonine-protein kinase 4.	0.749
I79_001484	Tead1	G3GUW0	G3HUV1	65 kDa Yes-associated protein.	Transcriptional enhancer factor TEF-1.	0.965
I79_001484	Tead3	G3GUW0	G3HZU9	65 kDa Yes-associated protein.	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.	0.917
I79_001484	Tead4	G3GUW0	G3GUJ1	65 kDa Yes-associated protein.	Transcriptional enhancer factor TEF-3.	0.975
I79_014483	I79_001484	G3HU75	G3GUW0	Serine/threonine-protein kinase 3.	65 kDa Yes-associated protein.	0.749
I79_014483	I79_018283	G3HU75	G3I4A6	Serine/threonine-protein kinase 3.	Mps one binder kinase activator-like 1B.	0.931
I79_014483	Lats1	G3HU75	G3H3S6	Serine/threonine-protein kinase 3.	Serine/threonine-protein kinase LATS1.	0.744
I79_014483	Lats2	G3HU75	G3H8I4	Serine/threonine-protein kinase 3.	Serine/threonine-protein kinase LATS2.	0.744
I79_014483	Sav1	G3HU75	G3IDP2	Serine/threonine-protein kinase 3.	Protein salvador-like 1.	0.934
I79_014483	Stk3	G3HU75	G3HK46	Serine/threonine-protein kinase 3.	Serine/threonine-protein kinase 3.	0.873
I79_014483	Stk4	G3HU75	G3HLS6	Serine/threonine-protein kinase 3.	Serine/threonine-protein kinase 4.	0.537
I79_014483	Wwtr1	G3HU75	G3HY70	Serine/threonine-protein kinase 3.	WW domain-containing transcription regulator protein 1.	0.749