(19 nodes) Cellular response to hepatocyte growth factor stimulus network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Lgmn	Legumain. (438 aa)
	Gclc	Glutamate--cysteine ligase catalytic subunit. (584 aa)
	Sirt2	NAD-dependent deacetylase sirtuin-2. (83 aa)
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	I79_013706	CREB-binding protein. (759 aa)
	I79_013707	CREB-binding protein. (202 aa)
	I79_016692	CREB-binding protein. (1054 aa)
	I79_016547	DCC-interacting protein 13-beta. (634 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	Vil1	Villin-1. (827 aa)
	Bcar1	Breast cancer anti-estrogen resistance protein 1. (879 aa)
	Rela	Transcription factor p65. (546 aa)
	I79_022778	Glutamate--cysteine ligase regulatory subunit. (225 aa)
	Il10	Interleukin-10. (178 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	Appl1	DCC-interacting protein 13-alpha. (664 aa)
	I79_014474	Cyclic AMP-responsive element-binding protein 1. (325 aa)
	I79_015109	Interleukin-6. (174 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Appl1	I79_016547	G3GUS8	G3HZP0	DCC-interacting protein 13-alpha.	DCC-interacting protein 13-beta.	0.999
Gclc	I79_022778	G3HIY9	G3IG96	Glutamate--cysteine ligase catalytic subunit.	Glutamate--cysteine ligase regulatory subunit.	0.995
Gsk3b	I79_014474	G3HAI0	G3HU68	Glycogen synthase kinase-3 beta.	Cyclic AMP-responsive element-binding protein 1.	0.599
Gsk3b	I79_015109	G3HAI0	G3HVW6	Glycogen synthase kinase-3 beta.	Interleukin-6.	0.408
Gsk3b	Nrp1	G3HAI0	G3HZ57	Glycogen synthase kinase-3 beta.	Neuropilin; Belongs to the neuropilin family.	0.408
Hgf	I79_015109	G3HPQ5	G3HVW6	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Interleukin-6.	0.511
Hgf	Il10	G3HPQ5	G3HB01	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Interleukin-10.	0.572
Hgf	Nrp1	G3HPQ5	G3HZ57	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Neuropilin; Belongs to the neuropilin family.	0.776
I79_013706	I79_013707	G3HS80	G3HS81	CREB-binding protein.	CREB-binding protein.	0.928
I79_013706	I79_014474	G3HS80	G3HU68	CREB-binding protein.	Cyclic AMP-responsive element-binding protein 1.	0.896
I79_013706	I79_016692	G3HS80	G3I026	CREB-binding protein.	CREB-binding protein.	0.888
I79_013706	Med1	G3HS80	G3H5X2	CREB-binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.652
I79_013706	Rela	G3HS80	G3IDM9	CREB-binding protein.	Transcription factor p65.	0.883
I79_013707	I79_013706	G3HS81	G3HS80	CREB-binding protein.	CREB-binding protein.	0.928
I79_013707	I79_014474	G3HS81	G3HU68	CREB-binding protein.	Cyclic AMP-responsive element-binding protein 1.	0.896
I79_013707	I79_016692	G3HS81	G3I026	CREB-binding protein.	CREB-binding protein.	0.941
I79_013707	Med1	G3HS81	G3H5X2	CREB-binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.652
I79_013707	Rela	G3HS81	G3IDM9	CREB-binding protein.	Transcription factor p65.	0.883
I79_014474	Gsk3b	G3HU68	G3HAI0	Cyclic AMP-responsive element-binding protein 1.	Glycogen synthase kinase-3 beta.	0.599
I79_014474	I79_013706	G3HU68	G3HS80	Cyclic AMP-responsive element-binding protein 1.	CREB-binding protein.	0.896