(22 nodes) Megakaryocyte development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_005506	Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha. (320 aa)
	I79_014053	Abl interactor 1. (280 aa)
	Srf	Serum response factor. (361 aa)
	I79_016457	Protein G6b. (200 aa)
	Ep300	Histone acetyltransferase p300. (2415 aa)
	Znf385a	Zinc finger protein 385A. (366 aa)
	Wasf2	Wiskott-Aldrich syndrome protein family member 2. (360 aa)
	I79_020737	Platelet glycoprotein V. (355 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	I79_006520	Friend leukemia integration 1 transcription factor. (404 aa)
	Gp9	Platelet glycoprotein IX. (177 aa)
	Nbeal2	Neurobeachin-like protein 2. (697 aa)
	I79_011301	Neurobeachin-like protein 2. (190 aa)
	Vps33b	Vacuolar protein sorting-associated protein 33B; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	Kit	Mast/stem cell growth factor receptor. (452 aa)
	I79_000238	Zinc finger protein ZFPM1. (744 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	Sh2b3	SH2B adapter protein 3. (364 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	Meis1	Homeobox protein Meis1. (390 aa)
	Tal1	T-cell acute lymphocytic leukemia protein 1-like. (329 aa)
	Gp1ba	Platelet glycoprotein Ib alpha chain. (446 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ep300	I79_000238	G3I534	G3GRU4	Histone acetyltransferase p300.	Zinc finger protein ZFPM1.	0.466
Ep300	Med1	G3I534	G3H5X2	Histone acetyltransferase p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.727
Ep300	Tal1	G3I534	G3GYT5	Histone acetyltransferase p300.	T-cell acute lymphocytic leukemia protein 1-like.	0.532
Gp1ba	Gp9	G3GYC3	G3HIE0	Platelet glycoprotein Ib alpha chain.	Platelet glycoprotein IX.	0.998
Gp1ba	I79_020737	G3GYC3	G3IAV5	Platelet glycoprotein Ib alpha chain.	Platelet glycoprotein V.	0.570
Gp1ba	Nbeal2	G3GYC3	G3HKS0	Platelet glycoprotein Ib alpha chain.	Neurobeachin-like protein 2.	0.867
Gp9	Gp1ba	G3HIE0	G3GYC3	Platelet glycoprotein IX.	Platelet glycoprotein Ib alpha chain.	0.998
Gp9	I79_020737	G3HIE0	G3IAV5	Platelet glycoprotein IX.	Platelet glycoprotein V.	0.837
Gp9	Nbeal2	G3HIE0	G3HKS0	Platelet glycoprotein IX.	Neurobeachin-like protein 2.	0.830
I79_000238	Ep300	G3GRU4	G3I534	Zinc finger protein ZFPM1.	Histone acetyltransferase p300.	0.466
I79_000238	Tal1	G3GRU4	G3GYT5	Zinc finger protein ZFPM1.	T-cell acute lymphocytic leukemia protein 1-like.	0.589
I79_004244	I79_016457	G3H277	G3HZF6	Tyrosine-protein phosphatase non-receptor type 11.	Protein G6b.	0.848
I79_004244	Kit	G3H277	G3IMP9	Tyrosine-protein phosphatase non-receptor type 11.	Mast/stem cell growth factor receptor.	0.759
I79_004244	Ptpn6	G3H277	G3GUQ5	Tyrosine-protein phosphatase non-receptor type 11.	Tyrosine-protein phosphatase non-receptor type 6.	0.585
I79_006520	Srf	G3H824	G3HYT2	Friend leukemia integration 1 transcription factor.	Serum response factor.	0.407
I79_006520	Tal1	G3H824	G3GYT5	Friend leukemia integration 1 transcription factor.	T-cell acute lymphocytic leukemia protein 1-like.	0.582
I79_011301	Nbeal2	G3HKS1	G3HKS0	Neurobeachin-like protein 2.	Neurobeachin-like protein 2.	0.881
I79_014053	Wasf2	G3HT41	G3I8T3	Abl interactor 1.	Wiskott-Aldrich syndrome protein family member 2.	0.970
I79_016457	I79_004244	G3HZF6	G3H277	Protein G6b.	Tyrosine-protein phosphatase non-receptor type 11.	0.848
I79_016457	Ptpn6	G3HZF6	G3GUQ5	Protein G6b.	Tyrosine-protein phosphatase non-receptor type 6.	0.764