(72 nodes) Aorta development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_019934	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (263 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	I79_013660	Beta-type platelet-derived growth factor receptor. (454 aa)
	Aplnr	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	I79_012894	Transcription factor AP-2 beta. (287 aa)
	Chd7	Chromodomain-helicase-DNA-binding protein 7. (615 aa)
	I79_012815	Chromodomain-helicase-DNA-binding protein 7. (150 aa)
	I79_012814	Chromodomain-helicase-DNA-binding protein 7. (100 aa)
	I79_012727	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
	I79_012060	Roundabout-like 2. (1397 aa)
	Fkbp10	Peptidylprolyl isomerase. (581 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	I79_010159	Roundabout-like 1. (1362 aa)
	Robo1	Roundabout-like 1. (129 aa)
	Kat6a	Histone acetyltransferase MYST3. (200 aa)
	I79_009100	Latent-transforming growth factor beta-binding protein 1. (1194 aa)
	I79_009030	T-box transcription factor TBX1. (293 aa)
	Loxl1	Lysyl oxidase-like 1. (543 aa)
	Tbx2	T-box transcription factor TBX2. (234 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Smad6	Mothers against decapentaplegic-like 6. (174 aa)
	I79_006745	Mothers against decapentaplegic-like 6. (71 aa)
	I79_005867	Dynamin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (885 aa)
	Smarca4	Putative global transcription activator SNF2L4. (1614 aa)
	Hectd1	E3 ubiquitin-protein ligase HECTD1. (2610 aa)
	Cxcr4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Myh10	Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
	Snx17	Sorting nexin-17. (470 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	I79_000661	Myosin light chain kinase, smooth muscle. (1766 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	Adamts9	A disintegrin and metalloproteinase with thrombospondin motifs 9. (489 aa)
	I79_000337	A disintegrin and metalloproteinase with thrombospondin motifs 9. (1068 aa)
	Prox1	Prospero homeobox protein 1. (738 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Egr2	Early growth response protein 2. (410 aa)
	I79_025625	Polycystin-2. (318 aa)
	Col3a1	Collagen alpha-1(III) chain. (1051 aa)
	I79_024932	Dynactin subunit 5. (82 aa)
	I79_024483	Polycystin-2. (192 aa)
	I79_024083	Protein-lysine 6-oxidase. (123 aa)
	Prickle1	Prickle-like protein 1. (619 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Rbpj	Recombining binding protein suppressor of hairless-like protein. (486 aa)
	Acvrl1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (776 aa)
	I79_021177	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1191 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
	Enpp1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
	Nprl3	UPF0171 protein C16orf35-like. (569 aa)
	Ap2b1	AP-2 complex subunit beta. (490 aa)
	I79_019340	Suppressor of fused-like. (144 aa)
	I79_019293	Protein fuzzy-like. (60 aa)
	Fuz	Protein fuzzy-like. (365 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	H671_4g11668	Chordin. (842 aa)
	Tab1	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (336 aa)
	Efemp2	EGF-containing fibulin-like extracellular matrix protein 2. (375 aa)
	Pde2a	cGMP-dependent 3',5'-cyclic phosphodiesterase; Belongs to the cyclic nucleotide phosphodiesterase family. (216 aa)
	Srf	Serum response factor. (361 aa)
	Sufu	Suppressor of fused-like. (266 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	Adamts6	A disintegrin and metalloproteinase with thrombospondin motifs 6. (1102 aa)
	Cntrl	Centriolin. (1787 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Foxh1	Forkhead box protein H1. (367 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Prdm1	PR domain zinc finger protein 1. (825 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	Plxnd1	Plexin-D1. (612 aa)
	I79_013668	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1. (809 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acvrl1	I79_000092	G3IC00	G3GRE7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.576
Acvrl1	I79_006745	G3IC00	G3H8N7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic-like 6.	0.598
Acvrl1	Smad6	G3IC00	G3H8N8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic-like 6.	0.598
Adamts6	I79_009100	G3HXI3	G3HEV3	A disintegrin and metalloproteinase with thrombospondin motifs 6.	Latent-transforming growth factor beta-binding protein 1.	0.470
Adamts9	I79_000337	G3GS31	G3GS30	A disintegrin and metalloproteinase with thrombospondin motifs 9.	A disintegrin and metalloproteinase with thrombospondin motifs 9.	0.839
Ap2b1	I79_001239	G3I8B9	G3GU85	AP-2 complex subunit beta.	Low-density lipoprotein receptor-related protein 2.	0.400
Ap2b1	I79_005867	G3I8B9	G3H6B2	AP-2 complex subunit beta.	Dynamin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.529
Chd7	I79_012814	G3HPU6	G3HPU4	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.886
Chd7	I79_012815	G3HPU6	G3HPU5	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.845
Col3a1	Efemp2	G3IM20	G3I2G7	Collagen alpha-1(III) chain.	EGF-containing fibulin-like extracellular matrix protein 2.	0.663
Col3a1	I79_024083	G3IM20	G3IJP7	Collagen alpha-1(III) chain.	Protein-lysine 6-oxidase.	0.544
Col3a1	Loxl1	G3IM20	G3HEI6	Collagen alpha-1(III) chain.	Lysyl oxidase-like 1.	0.478
Cxcr4	I79_000661	G3GZR2	G3GSP4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family.	Myosin light chain kinase, smooth muscle.	0.457
Dll4	Hey2	G3ICK3	G3IB43	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 2.	0.712
Dll4	I79_015033	G3ICK3	G3HVP3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1.	0.535
Dll4	I79_015503	G3ICK3	G3HWY8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.596
Dll4	Jag1	G3ICK3	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Dll4	Rbpj	G3ICK3	G3ICG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein.	0.800
Efemp2	Col3a1	G3I2G7	G3IM20	EGF-containing fibulin-like extracellular matrix protein 2.	Collagen alpha-1(III) chain.	0.663
Efemp2	Fkbp10	G3I2G7	G3HLV1	EGF-containing fibulin-like extracellular matrix protein 2.	Peptidylprolyl isomerase.	0.761