(38 nodes) Cellular response to vascular endothelial growth factor stimulus network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fn1	Fibronectin. (2486 aa)
	I79_001513	Early growth response protein 3. (333 aa)
	Map2k3	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (340 aa)
	I79_002099	Vascular endothelial growth factor receptor 1. (115 aa)
	I79_003683	Nogo-B receptor. (291 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	I79_005201	Serine/threonine-protein kinase D1. (116 aa)
	I79_005202	Serine/threonine-protein kinase D1. (748 aa)
	I79_007264	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (84 aa)
	Mapkapk2	MAPKAPK2. (307 aa)
	Nrp2	Neuropilin; Belongs to the neuropilin family. (909 aa)
	Pgf	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
	Vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
	I79_012498	Semaphorin-6A. (305 aa)
	Sema6a	Semaphorin-6A; Belongs to the semaphorin family. (503 aa)
	Xbp1	X-box binding protein 1 isoform 1. (330 aa)
	I79_012556	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
	I79_013660	Beta-type platelet-derived growth factor receptor. (454 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	Myo1c	Myosin-Ic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (487 aa)
	Sphk1	Sphingosine kinase 1. (383 aa)
	Nus1	Nogo-B receptor. (193 aa)
	Dab2ip	Disabled-like 2-interacting protein. (1065 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
	Anxa1	Annexin. (346 aa)
	I79_018849	Serine/threonine-protein kinase D2. (513 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
	Vegfb	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	Rela	Transcription factor p65. (546 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	Itgb1bp1	Integrin beta-1-binding protein 1. (199 aa)
	I79_023773	Nuclear receptor subfamily 4 group A member 1. (924 aa)
	I79_024097	Vascular cell adhesion protein 1. (225 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	I79_007264	G3H397	G3HA24	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	0.798
Akt1	I79_022034	G3H397	G3IE90	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.418
Akt1	I79_023773	G3H397	G3IIU4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear receptor subfamily 4 group A member 1.	0.508
Akt1	Map2k3	G3H397	G3GVI7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.	0.572
Akt1	Mapk14	G3H397	G3HZU1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.963
Akt1	Mapkapk2	G3H397	G3HB00	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	MAPKAPK2.	0.651
Akt1	Nrp1	G3H397	G3HZ57	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neuropilin; Belongs to the neuropilin family.	0.422
Akt1	Pgf	G3H397	G3HFQ6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family.	0.418
Akt1	Pik3ca	G3H397	G3I1C5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.985
Akt1	Pik3cd	G3H397	G3I7G5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.961
Akt1	Rela	G3H397	G3IDM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transcription factor p65.	0.558
Akt1	Xbp1	G3H397	G3HNZ9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	X-box binding protein 1 isoform 1.	0.405
Dab2ip	Pik3ca	G3HX88	G3I1C5	Disabled-like 2-interacting protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.403
Dab2ip	Sphk1	G3HX88	G3HTX9	Disabled-like 2-interacting protein.	Sphingosine kinase 1.	0.410
Dll4	I79_002099	G3ICK3	G3GWH4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor receptor 1.	0.461
Dll4	I79_012556	G3ICK3	G3HP52	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.536
Dll4	I79_022034	G3ICK3	G3IE90	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.466
Dll4	Nrp1	G3ICK3	G3HZ57	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neuropilin; Belongs to the neuropilin family.	0.408
I79_001513	I79_023773	G3GUY7	G3IIU4	Early growth response protein 3.	Nuclear receptor subfamily 4 group A member 1.	0.497
I79_002099	Dll4	G3GWH4	G3ICK3	Vascular endothelial growth factor receptor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.461