(27 nodes) T-helper cell differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rora	Nuclear receptor ROR-alpha. (959 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Atp7a	Copper-transporting ATPase 1. (1457 aa)
	Il21	Interleukin-21. (67 aa)
	Gpr183	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	I79_015109	Interleukin-6. (174 aa)
	I79_010073	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
	I79_011558	Ring finger and CCCH-type zinc finger domain-containing protein 2. (835 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	I79_017833	Lymphoid enhancer-binding factor 1. (276 aa)
	Entpd7	Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (558 aa)
	I79_021840	Nuclear receptor ROR-gamma. (341 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Hlx	H2.0-like homeobox protein. (374 aa)
	Foxp1	Forkhead box protein P1. (696 aa)
	Bcl6	B-cell lymphoma 6 protein-like. (707 aa)
	Tmem98	Transmembrane protein 98. (226 aa)
	I79_001358	Ras-related protein Rab-44. (166 aa)
	Cracr2a	EF-hand calcium-binding domain-containing protein 4B. (567 aa)
	Irf4	Interferon regulatory factor 4. (418 aa)
	Serpinc1	Roquin; Belongs to the serpin family. (1418 aa)
	Tbx21	T-box transcription factor TBX21. (365 aa)
	Il6r	Interleukin-6 receptor subunit alpha. (505 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	Batf	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	Sema4a	Semaphorin-4A; Belongs to the semaphorin family. (761 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Batf	Bcl6	G3HFR9	G3GT91	Basic leucine zipper transcriptional factor ATF-like.	B-cell lymphoma 6 protein-like.	0.469
Batf	Gata3	G3HFR9	G3GR59	Basic leucine zipper transcriptional factor ATF-like.	Trans-acting T-cell-specific transcription factor GATA-3.	0.499
Batf	I79_021840	G3HFR9	G3IDQ7	Basic leucine zipper transcriptional factor ATF-like.	Nuclear receptor ROR-gamma.	0.514
Batf	Irf4	G3HFR9	G3GWW9	Basic leucine zipper transcriptional factor ATF-like.	Interferon regulatory factor 4.	0.849
Batf	Rora	G3HFR9	G3IG02	Basic leucine zipper transcriptional factor ATF-like.	Nuclear receptor ROR-alpha.	0.520
Batf	Stat3	G3HFR9	G3HLW9	Basic leucine zipper transcriptional factor ATF-like.	Signal transducer and activator of transcription.	0.567
Bcl6	Batf	G3GT91	G3HFR9	B-cell lymphoma 6 protein-like.	Basic leucine zipper transcriptional factor ATF-like.	0.469
Bcl6	Gata3	G3GT91	G3GR59	B-cell lymphoma 6 protein-like.	Trans-acting T-cell-specific transcription factor GATA-3.	0.454
Bcl6	Il21	G3GT91	G3HTL7	B-cell lymphoma 6 protein-like.	Interleukin-21.	0.473
Bcl6	Irf4	G3GT91	G3GWW9	B-cell lymphoma 6 protein-like.	Interferon regulatory factor 4.	0.774
Bcl6	Stat3	G3GT91	G3HLW9	B-cell lymphoma 6 protein-like.	Signal transducer and activator of transcription.	0.521
Bcl6	Stat6	G3GT91	G3HW32	B-cell lymphoma 6 protein-like.	Signal transducer and activator of transcription.	0.523
Bcl6	Tbx21	G3GT91	G3H5U9	B-cell lymphoma 6 protein-like.	T-box transcription factor TBX21.	0.600
Cracr2a	I79_001358	G3GUJ7	G3GUJ6	EF-hand calcium-binding domain-containing protein 4B.	Ras-related protein Rab-44.	0.894
Gata3	Batf	G3GR59	G3HFR9	Trans-acting T-cell-specific transcription factor GATA-3.	Basic leucine zipper transcriptional factor ATF-like.	0.499
Gata3	Bcl6	G3GR59	G3GT91	Trans-acting T-cell-specific transcription factor GATA-3.	B-cell lymphoma 6 protein-like.	0.454
Gata3	I79_015109	G3GR59	G3HVW6	Trans-acting T-cell-specific transcription factor GATA-3.	Interleukin-6.	0.419
Gata3	I79_017833	G3GR59	G3I333	Trans-acting T-cell-specific transcription factor GATA-3.	Lymphoid enhancer-binding factor 1.	0.403
Gata3	I79_021840	G3GR59	G3IDQ7	Trans-acting T-cell-specific transcription factor GATA-3.	Nuclear receptor ROR-gamma.	0.492
Gata3	Irf4	G3GR59	G3GWW9	Trans-acting T-cell-specific transcription factor GATA-3.	Interferon regulatory factor 4.	0.621