STRINGSTRING
Tnfsf4 Tnfsf4 Il18 Il18 Igfbp2 Igfbp2 H671_3g9841 H671_3g9841 I79_005113 I79_005113 I79_005129 I79_005129 Jak3 Jak3 Igf1 Igf1 Cd86 Cd86 Tnfsf9 Tnfsf9 Il12rb1 Il12rb1 I79_023475 I79_023475 I79_022515 I79_022515 Rps3 Rps3 I79_020697 I79_020697 I79_019425 I79_019425 Epo Epo CgPICR_011244 CgPICR_011244 I79_016423 I79_016423 Ager Ager I79_015916 I79_015916 IL2 IL2 Il23a Il23a Fadd Fadd I79_011712 I79_011712 I79_011711 I79_011711 IL12B IL12B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tnfsf4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Igfbp2Insulin-like growth factor-binding protein 2. (177 aa)
H671_3g9841Interleukin-27 receptor subunit alpha. (566 aa)
I79_005113Interleukin-12 receptor beta-1 chain. (585 aa)
I79_005129Tyrosine-protein kinase JAK3. (330 aa)
Jak3Tyrosine-protein kinase JAK3. (222 aa)
Igf1Insulin-like growth factor I. (75 aa)
Cd86T-lymphocyte activation antigen CD86. (269 aa)
Tnfsf9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (307 aa)
Il12rb1Interleukin-12 receptor beta-1 chain. (183 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (117 aa)
I79_020697Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
I79_019425Apoptosis-associated speck-like protein containing a CARD. (192 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
CgPICR_01124440S ribosomal protein S3. (94 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
I79_015916Insulin-like growth factor II. (155 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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