(59 nodes) Positive regulation of protein import into nucleus network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	I79_008088	Heat shock protein HSP 90-beta. (412 aa)
	Zc3h12a	Ribonuclease ZC3H12A. (577 aa)
	I79_009500	Mitogen-activated protein kinase 1. (68 aa)
	I79_009958	Angiopoietin-1 receptor. (793 aa)
	Cdh1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
	Ubr5	E3 ubiquitin-protein ligase UBR5. (380 aa)
	I79_011384	E3 ubiquitin-protein ligase UBR5. (295 aa)
	Jup	Junction plakoglobin. (1148 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	I79_015109	Interleukin-6. (174 aa)
	I79_016292	Heat shock protein HSP 90-alpha. (205 aa)
	I79_016293	Heat shock protein HSP 90-alpha 1. (135 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	Ptpn5	Tyrosine-protein phosphatase non-receptor type 5. (507 aa)
	Trim28	Transcription intermediary factor 1-beta. (535 aa)
	I79_018653	Heat shock protein HSP 90-beta. (131 aa)
	Tardbp	TAR DNA-binding protein 43. (199 aa)
	I79_018871	TAR DNA-binding protein 43. (213 aa)
	I79_019552	Zinc finger protein ZPR1. (503 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Flna	Filamin-A. (2488 aa)
	I79_021138	Heat shock protein HSP 90-beta. (90 aa)
	I79_021139	Heat shock protein HSP 90-beta. (113 aa)
	Bag3	BAG family molecular chaperone regulator 3. (571 aa)
	I79_021590	Heat shock protein HSP 90-beta. (121 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	H671_2g5922	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	I79_024082	Heat shock protein HSP 90-beta. (166 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (355 aa)
	Prkcd	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
	Ptgs2	Prostaglandin G/H synthase 2. (604 aa)
	Tpr	Nucleoprotein TPR. (2122 aa)
	I79_002522	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (227 aa)
	I79_024397	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (128 aa)
	Chp2	Calcineurin B-likeous protein 2. (196 aa)
	I79_000010	Protein kinase C. (566 aa)
	H671_xg19992	Zinc finger protein ZPR1 isoform 1. (108 aa)
	I79_000806	Heat shock cognate protein HSP 90-beta. (102 aa)
	I79_000875	Zinc finger protein ZIC 1. (248 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CgPICR_014495	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	I79_013640	Heat shock protein HSP 90-alpha. (249 aa)
	I79_013671	Pre-mRNA-splicing factor RBM22. (241 aa)
	Gper1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	Dmap1	DNA methyltransferase 1-associated protein 1. (468 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Hsp90aa1	Heat shock protein HSP 90-alpha. (332 aa)
	Uaca	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1396 aa)
	I79_005111	Phosphatidylinositol 3-kinase regulatory subunit beta. (653 aa)
	I79_005201	Serine/threonine-protein kinase D1. (116 aa)
	I79_005202	Serine/threonine-protein kinase D1. (748 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Ect2	Protein ECT2. (881 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Hyal2	Hyaluronidase. (359 aa)
	I79_007634	Heat shock protein HSP 90-beta. (176 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bag3	Hsp90aa1	G3ICC2	G3H354	BAG family molecular chaperone regulator 3.	Heat shock protein HSP 90-alpha.	0.682
Bag3	I79_005111	G3ICC2	G3H4B1	BAG family molecular chaperone regulator 3.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.420
Bag3	Pik3r1	G3ICC2	G3H4N4	BAG family molecular chaperone regulator 3.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.420
Bag3	Tnfrsf1a	G3ICC2	G3GUL6	BAG family molecular chaperone regulator 3.	Tumor necrosis factor receptor superfamily member 1A.	0.624
Brca1	Cdk1	G3HM05	G3HVL1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.724
Brca1	Flna	G3HM05	G3IBK2	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Filamin-A.	0.590
Cdh1	Jup	G3HKU8	G3HLU9	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin.	0.997
Cdh1	Psen1	G3HKU8	G3HNF2	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.755
Cdh1	Tgfb1	G3HKU8	G3IA12	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Transforming growth factor beta-1.	0.510
Cdk1	Brca1	G3HVL1	G3HM05	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.724
Cdk1	Ect2	G3HVL1	G3H6H0	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Protein ECT2.	0.910
Cdk1	I79_009500	G3HVL1	G3HFY3	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 1.	0.415
Cdk1	Mapk14	G3HVL1	G3HZU1	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.432
Cdk1	Tpr	G3HVL1	G3GWV9	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Nucleoprotein TPR.	0.447
CgPICR_014495	H671_2g5922	G3HP89	G3IHE5	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.900
CgPICR_014495	Tpr	G3HP89	G3GWV9	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Nucleoprotein TPR.	0.473
Ect2	Cdk1	G3H6H0	G3HVL1	Protein ECT2.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.910
Flna	Brca1	G3IBK2	G3HM05	Filamin-A.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.590
Gli3	I79_006225	G3HVA3	G3H796	Zinc finger protein GLI3.	Sonic hedgehog protein.	0.662
Gli3	Smo	G3HVA3	G3GZ55	Zinc finger protein GLI3.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.917