STRINGSTRING
Tnfrsf1a Tnfrsf1a Lep Lep H671_5g13848 H671_5g13848 Isl1 Isl1 Il18 Il18 Crlf1 Crlf1 I79_005331 I79_005331 Csf2 Csf2 I79_005488 I79_005488 Il21 Il21 IL2 IL2 I79_015109 I79_015109 I79_015356 I79_015356 I79_015503 I79_015503 I79_017561 I79_017561 Clcf1 Clcf1 Epo Epo Ccl5 Ccl5 I79_020343 I79_020343 I79_020344 I79_020344 I79_021300 I79_021300 I79_021301 I79_021301 Jak2 Jak2 Osbp Osbp Cntf Cntf I79_024249 I79_024249 I79_024691 I79_024691 Kit Kit I79_025305 I79_025305 Hpx Hpx Tnf Tnf Igf1 Igf1 Cd40 Cd40 Lck Lck I79_007089 I79_007089 I79_007090 I79_007090 I79_007462 I79_007462 Il6r Il6r I79_008304 I79_008304 IL12B IL12B I79_010073 I79_010073 Hdac2 Hdac2 Il6st Il6st I79_010234 I79_010234 Il15 Il15 Fgfr3 Fgfr3 Fyn Fyn Il23a Il23a I79_013659 I79_013659 Lyn Lyn Osm Osm Lif Lif Parp14 Parp14 I79_000675 I79_000675
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tnfrsf1aTumor necrosis factor receptor superfamily member 1A. (355 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
H671_5g13848Interleukin-24-like protein. (160 aa)
Isl1Insulin gene enhancer protein ISL-1. (257 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Crlf1Cytokine receptor-like factor 1. (382 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
Csf2Granulocyte-macrophage colony-stimulating factor. (95 aa)
I79_005488Progesterone-induced-blocking factor 1. (757 aa)
Il21Interleukin-21. (67 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
I79_015109Interleukin-6. (174 aa)
I79_015356Heat shock factor protein 1. (524 aa)
I79_015503Transcription factor HES-1. (92 aa)
I79_017561Tyrosine-protein kinase Lyn. (101 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
Ccl5C-C motif chemokine. (91 aa)
I79_020343Cardiotrophin-2. (229 aa)
I79_020344Cardiotrophin-1. (203 aa)
I79_021300Poly [ADP-ribose] polymerase. (324 aa)
I79_021301Poly [ADP-ribose] polymerase 9. (112 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
OsbpOxysterol-binding protein; Belongs to the OSBP family. (736 aa)
CntfCiliary neurotrophic factor. (59 aa)
I79_024249Poly [ADP-ribose] polymerase 9. (106 aa)
I79_024691Poly [ADP-ribose] polymerase 9. (187 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_025305UPF0389 protein FAM162A. (213 aa)
HpxHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (461 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Igf1Insulin-like growth factor I. (75 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
LckProto-oncogene tyrosine-protein kinase LCK. (158 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007462Poly [ADP-ribose] polymerase 14. (125 aa)
Il6rInterleukin-6 receptor subunit alpha. (505 aa)
I79_008304Platelet endothelial cell adhesion molecule. (596 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
I79_010234Interleukin-31 receptor A. (530 aa)
Il15Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
FynProto-oncogene tyrosine-protein kinase Fyn. (232 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
LynTyrosine-protein kinase. (289 aa)
OsmOncostatin-M. (222 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
Parp14Poly [ADP-ribose] polymerase. (1786 aa)
I79_000675Poly [ADP-ribose] polymerase 9. (337 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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