(133 nodes) Signal transduction in response to DNA damage network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_022544	Tripartite motif-containing protein 39. (453 aa)
	Topbp1	DNA topoisomerase II-binding protein 1. (1517 aa)
	I79_002659	High mobility group protein HMGI-C. (103 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	Fancd2	Fanconi anemia group D2 protein-like. (1068 aa)
	I79_002347	Fanconi anemia group D2 protein-like. (261 aa)
	Hus1b	Checkpoint protein; Belongs to the HUS1 family. (277 aa)
	Acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	I79_002013	BRCA1-A complex subunit BRE. (288 aa)
	Ing4	Inhibitor of growth protein. (248 aa)
	Rhno1	Uncharacterized protein C12orf32-like. (245 aa)
	Foxm1	Forkhead box protein M1. (764 aa)
	Map3k20	Mitogen-activated protein kinase kinase kinase MLT. (445 aa)
	I79_001275	Uncharacterized protein. (119 aa)
	Taok3	Serine/threonine-protein kinase TAO3. (898 aa)
	Znf830	Zinc finger protein 830. (369 aa)
	Atad5	ATPase family AAA domain-containing protein 5. (1335 aa)
	CgPICR_012052	Growth factor receptor-bound protein 2. (217 aa)
	I79_000834	Protein downstream neighbor of Son. (113 aa)
	Donson	Protein downstream neighbor of Son. (188 aa)
	I79_000761	Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
	Xpc	DNA repair protein complementing XP-C cells-like. (926 aa)
	Usp10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (772 aa)
	I79_000250	F-box only protein 31. (436 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	Nek11	Serine/threonine-protein kinase Nek11. (196 aa)
	I79_003245	Serine/threonine-protein kinase Nek11. (119 aa)
	Tp53bp1	Tumor suppressor p53-binding protein 1. (1952 aa)
	Uimc1	BRCA1-A complex subunit RAP80. (722 aa)
	Atf2	Cyclic AMP-dependent transcription factor ATF-2. (487 aa)
	Sesn2	Sestrin-2. (480 aa)
	Rpa2	Replication protein A 32 kDa subunit. (248 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	Fam216a	Cell cycle checkpoint control protein RAD9B-like. (231 aa)
	Mfsd11	UNC93-like protein MFSD11. (446 aa)
	Wac	WW domain-containing adapter protein with coiled-coil. (601 aa)
	I79_005151	BRCA1-A complex subunit MERIT40. (362 aa)
	I79_005382	40S ribosomal protein S27. (52 aa)
	Msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (852 aa)
	Cdk5rap3	CDK5 regulatory subunit-associated protein 3. (455 aa)
	I79_006232	PAX-interacting protein 1. (79 aa)
	I79_007011	Protein phosphatase 1D. (490 aa)
	Clspn	Claspin. (1317 aa)
	Ccng1	Cyclin-G1-like protein; Belongs to the cyclin family. (294 aa)
	E2f1	Transcription factor E2F1. (367 aa)
	I79_007576	Protein Mdm4. (405 aa)
	Eme1	Crossover junction endonuclease EME1. (249 aa)
	Foxn3	Forkhead box protein N3. (188 aa)
	Eme2	Putative crossover junction endonuclease EME2. (377 aa)
	I79_008000	Mucin-1. (220 aa)
	Muc1	Mucin-1. (105 aa)
	Chek2	Serine/threonine-protein kinase Chk2. (539 aa)
	I79_008401	Centrosomal protein of 63 kDa. (443 aa)
	Tiprl	TIP41-like protein. (282 aa)
	Pml	Putative transcription factor PML. (540 aa)
	Izumo4	Uncharacterized protein C19orf36-like. (207 aa)
	Dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1492 aa)
	I79_009416	Serine-protein kinase ATM. (1640 aa)
	Batf	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	I79_010207	Eukaryotic translation initiation factor 2-alpha kinase 4. (1513 aa)
	Cradd	Death domain-containing protein CRADD. (117 aa)
	Tfap4	Transcription factor AP-4. (338 aa)
	Rad17	Cell cycle checkpoint protein RAD17. (683 aa)
	Cdkn1a	Cyclin-dependent kinase inhibitor 1. (163 aa)
	Rad1	Cell cycle checkpoint protein RAD1. (279 aa)
	Paxip1	PAX-interacting protein 1. (91 aa)
	I79_025641	BRCA1-A complex subunit Abraxas. (82 aa)
	I79_025593	Protein NDRG1. (129 aa)
	I79_025438	Uncharacterized protein C10orf90. (366 aa)
	Plk1	Serine/threonine-protein kinase PLK. (602 aa)
	I79_025189	Protein NDRG1. (323 aa)
	I79_024061	Ubiquitin carboxyl-terminal hydrolase 28; Belongs to the peptidase C19 family. (1027 aa)
	Trex1	Three prime repair exonuclease 1. (320 aa)
	Atrip	ATR-interacting protein. (690 aa)
	Casp2	Caspase-2; Belongs to the peptidase C14A family. (421 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	I79_011834	Breast cancer type 2 susceptibility protein-like. (143 aa)
	Brca2	Breast cancer type 2 susceptibility protein-like. (3008 aa)
	I79_012338	40S ribosomal protein S27. (52 aa)
	Magt1	Transcriptional regulator ATRX. (2344 aa)
	I79_012568	UPF0544 protein C5orf45-like. (154 aa)
	Mrnip	UPF0544 protein C5orf45-like. (195 aa)
	I79_012607	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (568 aa)
	Ier3	Radiation-inducible immediate-early gene IEX-1. (160 aa)
	Taok1	Serine/threonine-protein kinase TAO1. (723 aa)
	I79_023244	Bloom syndrome protein-like. (721 aa)
	Blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
	I79_022546	Tripartite motif-containing protein 39. (214 aa)
	Rsrp1	Pre-mRNA-splicing factor SYF2. (213 aa)
	I79_021945	Pre-mRNA-processing factor 19. (487 aa)
	Kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	Ticrr	Uncharacterized protein C15orf42-like. (1305 aa)
	Cdc14b	Dual specificity protein phosphatase CDC14B. (449 aa)
	Prap1	Proline-rich acidic protein 1. (148 aa)
	I79_020508	Protein NDRG1. (263 aa)
	Gigyf2	PERQ amino acid-rich with GYF domain-containing protein 2. (1298 aa)
	Hinfp	Histone H4 transcription factor. (513 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	I79_019971	RAD50-interacting protein 1. (600 aa)
	Foxo4	Forkhead box protein O4. (506 aa)
	Chek1	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
	I79_019348	Forkhead box protein M1. (185 aa)
	Triap1	TP53-regulated inhibitor of apoptosis 1. (79 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_018796	Integrator complex subunit 7. (652 aa)
	I79_018795	Integrator complex subunit 7. (108 aa)
	Dtl	Denticleless protein-like. (667 aa)
	Taok2	Serine/threonine-protein kinase TAO2. (1242 aa)
	Rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa)
	Pidd1	Leucine-rich repeat and death domain-containing protein. (915 aa)
	Rfwd3	RING finger and WD repeat domain-containing protein 3. (641 aa)
	I79_017872	RING finger and WD repeat domain-containing protein 3. (105 aa)
	I79_017613	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3486 aa)
	Mus81	Crossover junction endonuclease MUS81. (149 aa)
	Myo6	Myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (812 aa)
	I79_016946	Myosin-VI. (443 aa)
	I79_016810	Serine-protein kinase ATM. (473 aa)
	Tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (243 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	I79_016500	Ribosomal protein S6 kinase alpha-6; Belongs to the protein kinase superfamily. (342 aa)
	I79_016307	Lys-63-specific deubiquitinase BRCC36-like. (291 aa)
	I79_016104	BR serine/threonine-protein kinase 1. (410 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (281 aa)
	I79_015395	Replication protein A 30 kDa subunit. (333 aa)
	I79_015104	Tripartite motif-containing protein 39. (488 aa)
	Mbd4	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (560 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	Sde2	UPF0667 protein C1orf55-like. (439 aa)
	Mad2l2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	E2f7	Transcription factor E2F7. (900 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (705 aa)
	Fzr1	Fizzy-related protein-like. (493 aa)
	I79_013709	Death domain-containing protein CRADD. (120 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atad5	Blm	G3GTR7	G3IG14	ATPase family AAA domain-containing protein 5.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.819
Atad5	Brca1	G3GTR7	G3HM05	ATPase family AAA domain-containing protein 5.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.672
Atad5	Brca2	G3GTR7	G3HM86	ATPase family AAA domain-containing protein 5.	Breast cancer type 2 susceptibility protein-like.	0.606
Atad5	Chek1	G3GTR7	G3I7I8	ATPase family AAA domain-containing protein 5.	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	0.484
Atad5	Chek2	G3GTR7	G3HCC1	ATPase family AAA domain-containing protein 5.	Serine/threonine-protein kinase Chk2.	0.538
Atad5	Clspn	G3GTR7	G3H9V2	ATPase family AAA domain-containing protein 5.	Claspin.	0.892
Atad5	Dtl	G3GTR7	G3I5P1	ATPase family AAA domain-containing protein 5.	Denticleless protein-like.	0.821
Atad5	Fam216a	G3GTR7	G3H2A4	ATPase family AAA domain-containing protein 5.	Cell cycle checkpoint control protein RAD9B-like.	0.673
Atad5	Fancd2	G3GTR7	G3GX36	ATPase family AAA domain-containing protein 5.	Fanconi anemia group D2 protein-like.	0.458
Atad5	Hus1	G3GTR7	G3HXX1	ATPase family AAA domain-containing protein 5.	Checkpoint protein; Belongs to the HUS1 family.	0.462
Atad5	Hus1b	G3GTR7	G3GWX1	ATPase family AAA domain-containing protein 5.	Checkpoint protein; Belongs to the HUS1 family.	0.462
Atad5	I79_000761	G3GTR7	G3GSY9	ATPase family AAA domain-containing protein 5.	Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family.	0.468
Atad5	I79_002347	G3GTR7	G3GX35	ATPase family AAA domain-containing protein 5.	Fanconi anemia group D2 protein-like.	0.458
Atad5	I79_009416	G3GTR7	G3HFQ2	ATPase family AAA domain-containing protein 5.	Serine-protein kinase ATM.	0.524
Atad5	I79_011834	G3GTR7	G3HM85	ATPase family AAA domain-containing protein 5.	Breast cancer type 2 susceptibility protein-like.	0.606
Atad5	I79_012607	G3GTR7	G3HP98	ATPase family AAA domain-containing protein 5.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.488
Atad5	I79_015395	G3GTR7	G3HWN4	ATPase family AAA domain-containing protein 5.	Replication protein A 30 kDa subunit.	0.569
Atad5	I79_016810	G3GTR7	G3I0D1	ATPase family AAA domain-containing protein 5.	Serine-protein kinase ATM.	0.524
Atad5	I79_023244	G3GTR7	G3IHF5	ATPase family AAA domain-containing protein 5.	Bloom syndrome protein-like.	0.819
Atad5	Mad2l2	G3GTR7	G3HUM3	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.642