(12 nodes) Enucleate erythrocyte differentiation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_010700	Transcription factor Sp3. (441 aa)
	Sp3	Transcription factor Sp3. (338 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	Dnase2	Deoxyribonuclease-2-alpha-like protein. (371 aa)
	I79_009954	Macrophage erythroblast attacher. (67 aa)
	Maea	Macrophage erythroblast attacher. (348 aa)
	I79_011789	DNA-binding protein inhibitor ID-2. (185 aa)
	Rb1	Retinoblastoma-associated protein. (302 aa)
	Sp1	Transcription factor Sp1. (778 aa)
	I79_020066	CCAAT/enhancer-binding protein gamma. (93 aa)
	Tspo2	Peripheral-type benzodiazepine receptor-like protein 1. (136 aa)
	Mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I79_010700	Sp1	G3HJ66	G3HV45	Transcription factor Sp3.	Transcription factor Sp1.	0.611
Med1	Sp1	G3H5X2	G3HV45	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription factor Sp1.	0.967
Sp1	I79_010700	G3HV45	G3HJ66	Transcription factor Sp1.	Transcription factor Sp3.	0.611
Sp1	Med1	G3HV45	G3H5X2	Transcription factor Sp1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.967
Sp1	Sp3	G3HV45	G3GUC7	Transcription factor Sp1.	Transcription factor Sp3.	0.611
Sp3	Sp1	G3GUC7	G3HV45	Transcription factor Sp3.	Transcription factor Sp1.	0.611