(41 nodes) Negative regulation of DNA binding network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_011789	DNA-binding protein inhibitor ID-2. (185 aa)
	Ctnnbip1	Beta-catenin-interacting protein 1. (81 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	I79_021045	Heme oxygenase 1. (81 aa)
	Habp4	Intracellular hyaluronan-binding protein 4. (216 aa)
	I79_020958	Intracellular hyaluronan-binding protein 4. (123 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
	Hmox1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
	Rest	RE1-silencing transcription factor. (1047 aa)
	Lhx2	LIM/homeobox protein Lhx2. (385 aa)
	Nek2	Serine/threonine-protein kinase Nek2. (400 aa)
	I79_018682	Remodeling and spacing factor 1. (1308 aa)
	Znf593	Zinc finger protein 593. (134 aa)
	I79_017833	Lymphoid enhancer-binding factor 1. (276 aa)
	Per2	Period circadian protein-like 2. (1262 aa)
	Ddit3	DNA damage-inducible transcript 3. (167 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	Mad2l2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	Tfap4	Transcription factor AP-4. (338 aa)
	Ilrun	Uncharacterized protein C6orf106. (217 aa)
	Sri	Sorcin. (117 aa)
	I79_013004	F-box/WD repeat-containing protein 7. (709 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Gata1	Erythroid transcription factor-like protein. (330 aa)
	Hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
	I79_009953	Transcription factor AP-1. (72 aa)
	Id1	DNA-binding protein inhibitor ID-1. (157 aa)
	Fbxw9	F-box/WD repeat-containing protein 9. (458 aa)
	CgPICR_001195	Copine-1. (537 aa)
	E2f1	Transcription factor E2F1. (367 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Ankrd33b	Ankyrin repeat domain-containing protein 33B. (367 aa)
	Tnks	Poly [ADP-ribose] polymerase. (897 aa)
	I79_004332	Heat shock 70 kDa protein 4. (559 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Sin3a	Paired amphipathic helix protein Sin3a. (1274 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	I79_002659	High mobility group protein HMGI-C. (103 aa)
	Ercc4	DNA repair endonuclease XPF. (585 aa)
	Msx1	Homeobox protein MSX-1. (261 aa)
	Znf462	Zinc finger protein 462. (2487 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ddit3	I79_009953	G3HW45	G3HH56	DNA damage-inducible transcript 3.	Transcription factor AP-1.	0.496
E2f1	Hdac2	G3HAM7	G3HHV8	Transcription factor E2F1.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.635
E2f1	Sirt1	G3HAM7	G3HAB1	Transcription factor E2F1.	NAD-dependent deacetylase sirtuin-1.	0.660
Fbxw9	I79_009953	G3HCV9	G3HH56	F-box/WD repeat-containing protein 9.	Transcription factor AP-1.	0.629
Gata1	Hdac2	G3HND3	G3HHV8	Erythroid transcription factor-like protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.436
Gata1	I79_009953	G3HND3	G3HH56	Erythroid transcription factor-like protein.	Transcription factor AP-1.	0.498
Gata1	Lhx2	G3HND3	G3I8N8	Erythroid transcription factor-like protein.	LIM/homeobox protein Lhx2.	0.457
Gata1	Sin3a	G3HND3	G3H0F0	Erythroid transcription factor-like protein.	Paired amphipathic helix protein Sin3a.	0.423
Hdac2	E2f1	G3HHV8	G3HAM7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Transcription factor E2F1.	0.635
Hdac2	Gata1	G3HHV8	G3HND3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Erythroid transcription factor-like protein.	0.436
Hdac2	I79_009953	G3HHV8	G3HH56	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Transcription factor AP-1.	0.562
Hdac2	I79_017833	G3HHV8	G3I333	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Lymphoid enhancer-binding factor 1.	0.491
Hdac2	Rest	G3HHV8	G3I8Y7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	RE1-silencing transcription factor.	0.927
Hdac2	Sin3a	G3HHV8	G3H0F0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Paired amphipathic helix protein Sin3a.	0.998
Hdac2	Sirt1	G3HHV8	G3HAB1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	NAD-dependent deacetylase sirtuin-1.	0.645
Hey2	I79_015033	G3IB43	G3HVP3	Hairy/enhancer-of-split related with YRPW motif protein 2.	Hairy/enhancer-of-split related with YRPW motif protein 1.	0.668
Hmox1	Sirt1	G3IAI6	G3HAB1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	NAD-dependent deacetylase sirtuin-1.	0.451
I79_009953	Ddit3	G3HH56	G3HW45	Transcription factor AP-1.	DNA damage-inducible transcript 3.	0.496
I79_009953	Fbxw9	G3HH56	G3HCV9	Transcription factor AP-1.	F-box/WD repeat-containing protein 9.	0.629
I79_009953	Gata1	G3HH56	G3HND3	Transcription factor AP-1.	Erythroid transcription factor-like protein.	0.498