STRINGSTRING
Wnt5a Wnt5a I79_025972 I79_025972 Trib1 Trib1 Sorl1 Sorl1 Kit Kit Smpd1 Smpd1 Pak1 Pak1 Uchl1 Uchl1 I79_024744 I79_024744 I79_024271 I79_024271 I79_023937 I79_023937 Csk Csk Ntrk3 Ntrk3 Nppa Nppa Il1rn Il1rn Traf2 Traf2 Iqgap1 Iqgap1 Fzd4 Fzd4 I79_021837 I79_021837 I79_021836 I79_021836 I79_021835 I79_021835 Map3k11 Map3k11 I79_021789 I79_021789 Rps3 Rps3 Ghr Ghr I79_021564 I79_021564 Inppl1 Inppl1 I79_021125 I79_021125 I79_020969 I79_020969 I79_020968 I79_020968 Fgd4 Fgd4 Adam8 Adam8 I79_020594 I79_020594 Tgfb1 Tgfb1 Nox4 Nox4 H671_5g14804 H671_5g14804 Trib3 Trib3 I79_020009 I79_020009 I79_019934 I79_019934 I79_019878 I79_019878 Nup62 Nup62 Adra2a Adra2a Pdcd4 Pdcd4 Map4k2 Map4k2 Tgfa Tgfa CgPICR_011244 CgPICR_011244 I79_018306 I79_018306 Htr2a Htr2a I79_018131 I79_018131 Drd4 Drd4 Hras Hras I79_017859 I79_017859 Dvl3 Dvl3 Pdgfb Pdgfb Tab1 Tab1 I79_017561 I79_017561 Lyn Lyn Ptpn5 Ptpn5 Fzd10 Fzd10 IL1B IL1B Tlr4 Tlr4 I79_016567 I79_016567 Tnf Tnf I79_016430 I79_016430 I79_016423 I79_016423 Ager Ager Pdgfd Pdgfd Adipoq Adipoq I79_016051 I79_016051 Tmem130 Tmem130 I79_015983 I79_015983 I79_015809 I79_015809 Dab2ip Dab2ip Insr Insr H671_3g10913 H671_3g10913 PPARG PPARG Map3k12 Map3k12 Fzd5 Fzd5 Spry1 Spry1 Inpp5k Inpp5k Tdgf1 Tdgf1 Irak1 Irak1 Pdgfrb Pdgfrb I79_013660 I79_013660 Map2k7 Map2k7 Ajuba Ajuba Lax1 Lax1 Pdcd10 Pdcd10 Maged1 Maged1 Apoe Apoe I79_012394 I79_012394 I79_012384 I79_012384 I79_012336 I79_012336 Psen1 Psen1 Ccl19 Ccl19 App App Cbs Cbs Arhgef5 Arhgef5 Map3k13 Map3k13 Fgd2 Fgd2 I79_011154 I79_011154 Stk38 Stk38 I79_011140 I79_011140 Kitlg Kitlg Syk Syk Map3k1 Map3k1 Rasgrp1 Rasgrp1 Thbs1 Thbs1 I79_010159 I79_010159 Robo1 Robo1 Sfrp1 Sfrp1 Lime1 Lime1 Tnfsf11 Tnfsf11 I79_009795 I79_009795 Spry2 Spry2 I79_009116 I79_009116 I79_009115 I79_009115 Ptpn1 Ptpn1 Spry4 Spry4 Fgf1 Fgf1 I79_008941 I79_008941 Gba Gba Axin1 Axin1 Tsc2 Tsc2 Mapk8ip3 Mapk8ip3 I79_007935 I79_007935 Bmp7 Bmp7 Dusp16 Dusp16 Trib2 Trib2 Mef2c Mef2c Gsk3b Gsk3b Il34 Il34 Dusp1 Dusp1 Cav1 Cav1 Cd40 Cd40 Skor1 Skor1 Dusp19 Dusp19 Mst1r Mst1r Hyal2 Hyal2 Dusp7 Dusp7 I79_006547 I79_006547 Vangl2 Vangl2 Dkk1 Dkk1 I79_006254 I79_006254 I79_005718 I79_005718 Cdk5rap3 Cdk5rap3 Nod2 Nod2 I79_005573 I79_005573 Rgs2 Rgs2 I79_004922 I79_004922 Sh2b3 Sh2b3 Erp29 Erp29 I79_004285 I79_004285 I79_004035 I79_004035 I79_004031 I79_004031 Rgs14 Rgs14 Cav3 Cav3 Edn1 Edn1 Sfrp5 Sfrp5 Tlr9 Tlr9 I79_003212 I79_003212 Gpr39 Gpr39 Traf6 Traf6 Hipk3 Hipk3 I79_003024 I79_003024 Ptprj Ptprj Mapk8ip1 Mapk8ip1 Phf23 Phf23 I79_002696 I79_002696 Pik3r5 Pik3r5 I79_002662 I79_002662 Src Src Ezh2 Ezh2 Hgs Hgs Agt Agt Edn3 Edn3 I79_002099 I79_002099 Prkcd Prkcd Ptpn6 Ptpn6 Ntf3 Ntf3 Dtnbp1 Dtnbp1 Taok3 Taok3 I79_001046 I79_001046 Lgals9 Lgals9 I79_000959 I79_000959 I79_000697 I79_000697 Dusp10 Dusp10 Aida Aida ilk ilk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_025972Hepatocyte growth factor-regulated tyrosine kinase substrate. (147 aa)
Trib1Tribbles-like 1. (286 aa)
Sorl1Sortilin-related receptor. (223 aa)
KitMast/stem cell growth factor receptor. (452 aa)
Smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (593 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
Uchl1Ubiquitin carboxyl-terminal hydrolase. (219 aa)
I79_0247445-hydroxytryptamine receptor 2B. (407 aa)
I79_024271NT-3 growth factor receptor. (114 aa)
I79_023937Sortilin-related receptor. (88 aa)
CskTyrosine-protein kinase. (450 aa)
Ntrk3Tyrosine-protein kinase receptor. (226 aa)
NppaAtrial natriuretic factor. (362 aa)
Il1rnInterleukin-1. (157 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Iqgap1Ras GTPase-activating-like protein IQGAP1. (1675 aa)
Fzd4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
I79_021837Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
I79_021836Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)
I79_021835Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
Map3k11Mitogen-activated protein kinase kinase kinase. (850 aa)
I79_021789NT-3 growth factor receptor. (389 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (117 aa)
GhrGrowth hormone receptor. (345 aa)
I79_021564Pro-epidermal growth factor. (699 aa)
Inppl1Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
I79_021125Epigen. (135 aa)
I79_020969Fibroblast growth factor 18. (85 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
Fgd4FYVE, RhoGEF and PH domain-containing protein 4. (665 aa)
Adam8Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
I79_020594Tumor protein D53. (162 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Nox4NADPH oxidase 4. (130 aa)
H671_5g14804Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1012 aa)
Trib3Tribbles-like 3. (353 aa)
I79_020009Phosphodiesterase. (597 aa)
I79_019934Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (263 aa)
I79_019878Sortilin. (1038 aa)
Nup62Nuclear pore glycoprotein p62. (521 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
Map4k2Mitogen-activated protein kinase kinase kinase kinase 2. (259 aa)
TgfaProtransforming growth factor alpha. (211 aa)
CgPICR_01124440S ribosomal protein S3. (94 aa)
I79_018306Ephrin type-A receptor 4. (932 aa)
Htr2a5-hydroxytryptamine receptor 2A. (264 aa)
I79_0181315-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
Drd4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
HrasGTPase HRas-like protein. (189 aa)
I79_017859A-kinase anchor protein 13. (2703 aa)
Dvl3Segment polarity protein dishevelled-like DVL-3. (503 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Tab1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (336 aa)
I79_017561Tyrosine-protein kinase Lyn. (101 aa)
LynTyrosine-protein kinase. (289 aa)
Ptpn5Tyrosine-protein phosphatase non-receptor type 5. (507 aa)
Fzd10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (488 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
I79_016567Zinc finger E-box-binding homeobox 2. (1282 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
I79_016430Tenascin-X. (2530 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
PdgfdPlatelet-derived growth factor D. (253 aa)
AdipoqAdiponectin. (248 aa)
I79_016051Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
Tmem130Transmembrane protein 130. (461 aa)
I79_015983Teneurin-1. (1750 aa)
I79_0158093-hydroxy-3-methylglutaryl-coenzyme A reductase. (931 aa)
Dab2ipDisabled-like 2-interacting protein. (1065 aa)
InsrInsulin receptor. (114 aa)
H671_3g10913Protein sprouty-like 4. (82 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Map3k12Mitogen-activated protein kinase kinase kinase 12. (274 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (616 aa)
Spry1Protein sprouty-like 1. (313 aa)
Inpp5kInositol polyphosphate 5-phosphatase K. (451 aa)
Tdgf1Receptor-transporting protein 3. (313 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (494 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
AjubaProtein ajuba. (214 aa)
Lax1Lymphocyte transmembrane adapter 1. (408 aa)
Pdcd10Programmed cell death protein 10. (210 aa)
Maged1Melanoma-associated antigen D1-like protein. (776 aa)
ApoeApolipoprotein E. (313 aa)
I79_012394Mitogen-activated protein kinase kinase kinase 10. (594 aa)
I79_012384Leukocyte common antigen. (962 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
Psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
Ccl19C-C motif chemokine. (117 aa)
AppAmyloid beta A4 protein. (433 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
Arhgef5Rho guanine nucleotide exchange factor 5. (1561 aa)
Map3k13Mitogen-activated protein kinase kinase kinase 13. (431 aa)
Fgd2FYVE, RhoGEF and PH domain-containing protein 2. (250 aa)
I79_011154FYVE, RhoGEF and PH domain-containing protein 2. (359 aa)
Stk38Serine/threonine-protein kinase 38. (193 aa)
I79_011140Serine/threonine-protein kinase 38. (130 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SykTyrosine-protein kinase. (611 aa)
Map3k1Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
Rasgrp1RAS guanyl-releasing protein 1. (787 aa)
Thbs1Thrombospondin-1. (533 aa)
I79_010159Roundabout-like 1. (1362 aa)
Robo1Roundabout-like 1. (129 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
Lime1Lck-interacting transmembrane adapter 1. (218 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
I79_009795Mitogen-activated protein kinase kinase kinase 4. (1824 aa)
Spry2Protein sprouty-like 2. (316 aa)
I79_009116Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
I79_009115Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
Spry4Protein sprouty-like 4. (100 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
GbaGlucosylceramidase. (515 aa)
Axin1Axin-1. (863 aa)
Tsc2Tuberin. (1546 aa)
Mapk8ip3C-jun-amino-terminal kinase-interacting protein 3. (1073 aa)
I79_007935C-jun-amino-terminal kinase-interacting protein 3. (95 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Dusp16Dual specificity protein phosphatase 16. (80 aa)
Trib2Tribbles-like 2. (291 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Il34Interleukin-34. (201 aa)
Dusp1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
Skor1Dual specificity mitogen-activated protein kinase kinase 5. (719 aa)
Dusp19Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
Mst1rMacrophage-stimulating protein receptor. (1382 aa)
Hyal2Hyaluronidase. (359 aa)
Dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (320 aa)
I79_006547Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (311 aa)
Vangl2Vang-like protein. (521 aa)
Dkk1Dickkopf-related protein 1. (269 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
I79_005718Cell division cycle 2-related protein kinase 7. (1379 aa)
Cdk5rap3CDK5 regulatory subunit-associated protein 3. (455 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
I79_004922SAM and SH3 domain-containing protein 1. (999 aa)
Sh2b3SH2B adapter protein 3. (364 aa)
Erp29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (260 aa)
I79_004285p2X purinoceptor 7. (805 aa)
I79_004035Disintegrin and metalloproteinase domain-containing protein 9. (1196 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
Rgs14Regulator of G-protein signaling 14. (817 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Edn1Endothelin-1. (202 aa)
Sfrp5Secreted frizzled-related protein 5. (247 aa)
Tlr9Toll-like receptor 9. (1239 aa)
I79_003212G-protein coupled receptor 39. (151 aa)
Gpr39G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (289 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Hipk3Homeodomain-interacting protein kinase 3. (513 aa)
I79_003024Homeodomain-interacting protein kinase 3; Belongs to the protein kinase superfamily. (366 aa)
PtprjReceptor-type tyrosine-protein phosphatase eta. (1077 aa)
Mapk8ip1C-jun-amino-terminal kinase-interacting protein 1. (617 aa)
Phf23Segment polarity protein dishevelled-like DVL-2. (697 aa)
I79_002696Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
Pik3r5Phosphoinositide 3-kinase regulatory subunit 5. (148 aa)
I79_002662Interleukin-1 receptor-associated kinase 3. (537 aa)
SrcTyrosine-protein kinase. (536 aa)
Ezh2Histone-lysine N-methyltransferase EZH2. (746 aa)
HgsHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (776 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
Edn3Endothelin-3. (274 aa)
I79_002099Vascular endothelial growth factor receptor 1. (115 aa)
PrkcdNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
Ptpn6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
Dtnbp1Dysbindin. (125 aa)
Taok3Serine/threonine-protein kinase TAO3. (898 aa)
I79_001046Neurofibromin. (2164 aa)
Lgals9Kinase suppressor of Ras 1. (966 aa)
I79_000959CMRF35-like molecule 8. (295 aa)
I79_000697Mitogen-activated protein kinase kinase kinase 7. (287 aa)
Dusp10Dual specificity protein phosphatase 10. (482 aa)
AidaAxin interactor, dorsalization-associated protein. (124 aa)
ilkIntegrin-linked protein kinase. (452 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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