(61 nodes) Negative regulation of MAP kinase activity network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Sorl1	Sortilin-related receptor. (223 aa)
	I79_002662	Interleukin-1 receptor-associated kinase 3. (537 aa)
	Mapk8ip1	C-jun-amino-terminal kinase-interacting protein 1. (617 aa)
	Ptprj	Receptor-type tyrosine-protein phosphatase eta. (1077 aa)
	I79_003024	Homeodomain-interacting protein kinase 3; Belongs to the protein kinase superfamily. (366 aa)
	Hipk3	Homeodomain-interacting protein kinase 3. (513 aa)
	Sfrp5	Secreted frizzled-related protein 5. (247 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Rgs14	Regulator of G-protein signaling 14. (817 aa)
	Sh2b3	SH2B adapter protein 3. (364 aa)
	Rgs2	Regulator of G-protein signaling 2. (207 aa)
	I79_005573	Secreted frizzled-related protein 2. (268 aa)
	Cdk5rap3	CDK5 regulatory subunit-associated protein 3. (455 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (320 aa)
	Hyal2	Hyaluronidase. (359 aa)
	Dusp19	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	Gsk3b	Glycogen synthase kinase-3 beta. (328 aa)
	Dusp16	Dual specificity protein phosphatase 16. (80 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Tsc2	Tuberin. (1546 aa)
	Gba	Glucosylceramidase. (515 aa)
	Spry4	Protein sprouty-like 4. (100 aa)
	Ptpn1	Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
	I79_009115	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
	I79_009116	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
	Spry2	Protein sprouty-like 2. (316 aa)
	Sfrp1	Secreted frizzled-related protein 1. (104 aa)
	I79_011140	Serine/threonine-protein kinase 38. (130 aa)
	Stk38	Serine/threonine-protein kinase 38. (193 aa)
	Apoe	Apolipoprotein E. (313 aa)
	Lax1	Lymphocyte transmembrane adapter 1. (408 aa)
	Inpp5k	Inositol polyphosphate 5-phosphatase K. (451 aa)
	Spry1	Protein sprouty-like 1. (313 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	H671_3g10913	Protein sprouty-like 4. (82 aa)
	Dab2ip	Disabled-like 2-interacting protein. (1065 aa)
	I79_015809	3-hydroxy-3-methylglutaryl-coenzyme A reductase. (931 aa)
	Tmem130	Transmembrane protein 130. (461 aa)
	Adipoq	Adiponectin. (248 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Ptpn5	Tyrosine-protein phosphatase non-receptor type 5. (507 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	I79_017561	Tyrosine-protein kinase Lyn. (101 aa)
	Pdcd4	Programmed cell death protein 4. (469 aa)
	Nup62	Nuclear pore glycoprotein p62. (521 aa)
	I79_019878	Sortilin. (1038 aa)
	Inppl1	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
	Nppa	Atrial natriuretic factor. (362 aa)
	I79_023937	Sortilin-related receptor. (88 aa)
	Uchl1	Ubiquitin carboxyl-terminal hydrolase. (219 aa)
	Aida	Axin interactor, dorsalization-associated protein. (124 aa)
	Dusp10	Dual specificity protein phosphatase 10. (482 aa)
	I79_000959	CMRF35-like molecule 8. (295 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	Prkcd	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (593 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	Agt	G3HYG0	G3GX14	Adiponectin.	Angiotensinogen; Belongs to the serpin family.	0.453
Adipoq	Apoe	G3HYG0	G3HPC9	Adiponectin.	Apolipoprotein E.	0.590
Adipoq	IL1B	G3HYG0	G3I1B0	Adiponectin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.595
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Agt	Adipoq	G3GX14	G3HYG0	Angiotensinogen; Belongs to the serpin family.	Adiponectin.	0.453
Agt	Apoe	G3GX14	G3HPC9	Angiotensinogen; Belongs to the serpin family.	Apolipoprotein E.	0.495
Agt	Nppa	G3GX14	G3IHM2	Angiotensinogen; Belongs to the serpin family.	Atrial natriuretic factor.	0.575
Agt	PPARG	G3GX14	G3HVG0	Angiotensinogen; Belongs to the serpin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.411
Apoe	Adipoq	G3HPC9	G3HYG0	Apolipoprotein E.	Adiponectin.	0.590
Apoe	Agt	G3HPC9	G3GX14	Apolipoprotein E.	Angiotensinogen; Belongs to the serpin family.	0.495
Apoe	I79_015809	G3HPC9	G3HXP6	Apolipoprotein E.	3-hydroxy-3-methylglutaryl-coenzyme A reductase.	0.586
Apoe	I79_019878	G3HPC9	G3I8K3	Apolipoprotein E.	Sortilin.	0.826
Apoe	I79_023937	G3HPC9	G3IJA4	Apolipoprotein E.	Sortilin-related receptor.	0.601
Apoe	IL1B	G3HPC9	G3I1B0	Apolipoprotein E.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.481
Apoe	PPARG	G3HPC9	G3HVG0	Apolipoprotein E.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.652
Apoe	Sorl1	G3HPC9	G3INN7	Apolipoprotein E.	Sortilin-related receptor.	0.601
Bmp7	I79_006254	G3HBL1	G3H7C4	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.808
Cav1	Cav3	G3H9I8	G3H113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.938
Cav1	Gsk3b	G3H9I8	G3HAI0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase-3 beta.	0.402
Cav1	I79_017561	G3H9I8	G3I2D2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase Lyn.	0.405