(40 nodes) Blood vessel endothelial cell migration network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cdh5	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (763 aa)
	I79_025518	Ephrin-B2. (123 aa)
	I79_025535	Ephrin-B2. (125 aa)
	I79_025726	Ephrin-B2. (121 aa)
	I79_002944	Phosphatidylinositol 3-kinase regulatory subunit gamma. (460 aa)
	Msrb3	Inner nuclear membrane protein Man1. (479 aa)
	Vhl	Von Hippel-Lindau disease tumor suppressor. (134 aa)
	Emp2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
	I79_001513	Early growth response protein 3. (333 aa)
	I79_001024	Ephrin-B2; Belongs to the ephrin family. (373 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	I79_023002	Receptor protein-tyrosine kinase. (650 aa)
	I79_023145	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1948 aa)
	I79_023773	Nuclear receptor subfamily 4 group A member 1. (924 aa)
	Cln3	Battenin. (400 aa)
	I79_024593	Uncharacterized protein. (194 aa)
	I79_024975	Ephrin-B2. (148 aa)
	I79_025170	Slit-like 2 protein. (345 aa)
	I79_025433	Ephrin-B2; Belongs to the ephrin family. (70 aa)
	I79_025496	Ephrin-B2. (147 aa)
	I79_025497	Ephrin-B2; Belongs to the ephrin family. (69 aa)
	Clec14a	C-type lectin domain family 14 member A. (333 aa)
	Apoa1	Apolipoprotein A-I. (264 aa)
	Sox18	Transcription factor SOX-18. (377 aa)
	I79_021151	Ephrin-B2. (178 aa)
	I79_010159	Roundabout-like 1. (1362 aa)
	I79_026231	Ephrin-B2; Belongs to the ephrin family. (68 aa)
	Robo1	Roundabout-like 1. (129 aa)
	Gpld1	Phosphatidylinositol-glycan-specific phospholipase D. (778 aa)
	Gpx1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Srf	Serum response factor. (361 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	I79_013999	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
	Adtrp	Uncharacterized protein C6orf105-like. (148 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	I79_013907	Ephrin-B2. (148 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	I79_002944	G3H397	G3GYN9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.949
Akt1	I79_022034	G3H397	G3IE90	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.418
Akt1	I79_023773	G3H397	G3IIU4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear receptor subfamily 4 group A member 1.	0.508
Akt1	Itgb1	G3H397	G3HZ55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.659
Akt1	Nrp1	G3H397	G3HZ57	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neuropilin; Belongs to the neuropilin family.	0.422
Akt1	Srf	G3H397	G3HYT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serum response factor.	0.403
Apoa1	Scarb1	G3I7Q1	G3HX53	Apolipoprotein A-I.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.406
Cdh5	I79_012336	G3H665	G3HNJ8	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Protein tyrosine kinase 2 beta.	0.443
Cdh5	I79_022034	G3H665	G3IE90	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.827
Cdh5	Sox18	G3H665	G3IBT0	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Transcription factor SOX-18.	0.527
Clec14a	I79_022034	G3I7F8	G3IE90	C-type lectin domain family 14 member A.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.582
Clec14a	Sox18	G3I7F8	G3IBT0	C-type lectin domain family 14 member A.	Transcription factor SOX-18.	0.427
Gpld1	Itgb1	G3HDW7	G3HZ55	Phosphatidylinositol-glycan-specific phospholipase D.	Integrin beta; Belongs to the integrin beta chain family.	0.447
I79_001024	I79_023002	G3GTN7	G3IGS6	Ephrin-B2; Belongs to the ephrin family.	Receptor protein-tyrosine kinase.	0.688
I79_001024	Nrp1	G3GTN7	G3HZ57	Ephrin-B2; Belongs to the ephrin family.	Neuropilin; Belongs to the neuropilin family.	0.400
I79_001513	I79_023773	G3GUY7	G3IIU4	Early growth response protein 3.	Nuclear receptor subfamily 4 group A member 1.	0.497
I79_002944	Akt1	G3GYN9	G3H397	Phosphatidylinositol 3-kinase regulatory subunit gamma.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.949
I79_002944	I79_012336	G3GYN9	G3HNJ8	Phosphatidylinositol 3-kinase regulatory subunit gamma.	Protein tyrosine kinase 2 beta.	0.457
I79_002944	I79_022034	G3GYN9	G3IE90	Phosphatidylinositol 3-kinase regulatory subunit gamma.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.565
I79_002944	Itgb1	G3GYN9	G3HZ55	Phosphatidylinositol 3-kinase regulatory subunit gamma.	Integrin beta; Belongs to the integrin beta chain family.	0.935