(72 nodes) Endothelial cell migration network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_006232	PAX-interacting protein 1. (79 aa)
	Cdh5	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (763 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	S100z	Protein S100; Belongs to the S-100 family. (99 aa)
	Adgra2	Putative G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1048 aa)
	I79_002944	Phosphatidylinositol 3-kinase regulatory subunit gamma. (460 aa)
	Msrb3	Inner nuclear membrane protein Man1. (479 aa)
	Vhl	Von Hippel-Lindau disease tumor suppressor. (134 aa)
	Emp2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
	Loxl2	Lysyl oxidase-like 2. (300 aa)
	I79_001513	Early growth response protein 3. (333 aa)
	I79_001232	Paxillin; Belongs to the phospholipase A2 family. (642 aa)
	Pxn	Paxillin. (388 aa)
	I79_001024	Ephrin-B2; Belongs to the ephrin family. (373 aa)
	Cdh13	Cadherin-13. (377 aa)
	I79_024593	Uncharacterized protein. (194 aa)
	I79_024975	Ephrin-B2. (148 aa)
	I79_025170	Slit-like 2 protein. (345 aa)
	I79_025433	Ephrin-B2; Belongs to the ephrin family. (70 aa)
	I79_025496	Ephrin-B2. (147 aa)
	I79_025497	Ephrin-B2; Belongs to the ephrin family. (69 aa)
	I79_026231	Ephrin-B2; Belongs to the ephrin family. (68 aa)
	Paxip1	PAX-interacting protein 1. (91 aa)
	I79_025726	Ephrin-B2. (121 aa)
	I79_025518	Ephrin-B2. (123 aa)
	Cln3	Battenin. (400 aa)
	I79_024117	Protein tyrosine phosphatase type IVA 3. (148 aa)
	I79_023773	Nuclear receptor subfamily 4 group A member 1. (924 aa)
	I79_023721	Leupaxin. (365 aa)
	I79_023145	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1948 aa)
	I79_023002	Receptor protein-tyrosine kinase. (650 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021151	Ephrin-B2. (178 aa)
	Sox18	Transcription factor SOX-18. (377 aa)
	Apoa1	Apolipoprotein A-I. (264 aa)
	Clec14a	C-type lectin domain family 14 member A. (333 aa)
	Ptk2	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	I79_018241	Serine/threonine-protein kinase PRKX. (388 aa)
	Coro1b	Coronin; Belongs to the WD repeat coronin family. (484 aa)
	Gcg	Seprase; Belongs to the peptidase S9B family. (561 aa)
	I79_016618	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Srf	Serum response factor. (361 aa)
	Scarb1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	Lgals8	Galectin. (316 aa)
	Plxnd1	Plexin-D1. (612 aa)
	Ccbe1	Collagen and calcium-binding EGF domain-containing protein 1. (303 aa)
	I79_025535	Ephrin-B2. (125 aa)
	I79_013999	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
	Adtrp	Uncharacterized protein C6orf105-like. (148 aa)
	I79_013907	Ephrin-B2. (148 aa)
	I79_013771	Calcitonin. (206 aa)
	I79_012336	Protein tyrosine kinase 2 beta. (53 aa)
	Stard13	StAR-related lipid transfer protein 13. (1113 aa)
	I79_010159	Roundabout-like 1. (1362 aa)
	Robo1	Roundabout-like 1. (129 aa)
	Gpld1	Phosphatidylinositol-glycan-specific phospholipase D. (778 aa)
	Gipc1	PDZ domain-containing protein GIPC1. (333 aa)
	I79_008304	Platelet endothelial cell adhesion molecule. (596 aa)
	I79_024363	Pleckstrin-likey domain-containing family G member 5. (593 aa)
	I79_024255	Galectin. (284 aa)
	I79_008250	Endothelin-2. (137 aa)
	Rab13	Ras-related protein Rab-13. (199 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	Fstl1	Follistatin-related protein 1. (583 aa)
	I79_007339	Protein NOV-like. (256 aa)
	Itgb2	Integrin beta. (769 aa)
	Gpx1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
	Tgfbr1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	I79_001232	G3H397	G3GU78	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Paxillin; Belongs to the phospholipase A2 family.	0.426
Akt1	I79_002944	G3H397	G3GYN9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.949
Akt1	I79_007693	G3H397	G3HB72	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.835
Akt1	I79_008304	G3H397	G3HCT8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Platelet endothelial cell adhesion molecule.	0.436
Akt1	I79_018586	G3H397	G3I540	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.767
Akt1	I79_022034	G3H397	G3IE90	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.418
Akt1	I79_023773	G3H397	G3IIU4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear receptor subfamily 4 group A member 1.	0.508
Akt1	Itgb1	G3H397	G3HZ55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.659
Akt1	Nrp1	G3H397	G3HZ57	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neuropilin; Belongs to the neuropilin family.	0.422
Akt1	Ptk2	G3H397	G3I7E2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.645
Akt1	Pxn	G3H397	G3GU77	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Paxillin.	0.426
Akt1	Srf	G3H397	G3HYT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serum response factor.	0.403
Apoa1	Scarb1	G3I7Q1	G3HX53	Apolipoprotein A-I.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.406
Ccbe1	Sox18	G3HUJ0	G3IBT0	Collagen and calcium-binding EGF domain-containing protein 1.	Transcription factor SOX-18.	0.410
Cdh13	Cdh5	G3GRY8	G3H665	Cadherin-13.	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	0.461
Cdh13	I79_023145	G3GRY8	G3IH63	Cadherin-13.	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.544
Cdh5	Cdh13	G3H665	G3GRY8	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-13.	0.461
Cdh5	I79_007693	G3H665	G3HB72	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Nitric oxide synthase; Produces nitric oxide (NO).	0.489
Cdh5	I79_008304	G3H665	G3HCT8	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Platelet endothelial cell adhesion molecule.	0.856
Cdh5	I79_012336	G3H665	G3HNJ8	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins.	Protein tyrosine kinase 2 beta.	0.443