STRINGSTRING
IL1B IL1B I79_018761 I79_018761 I79_018661 I79_018661 Agtr2 Agtr2 Sstr4 Sstr4 Slc43a2 Slc43a2 Pla2g6 Pla2g6 I79_017861 I79_017861 I79_017638 I79_017638 I79_017637 I79_017637 Per2 Per2 Pla2g3 Pla2g3 Htr1a Htr1a I79_018762 I79_018762 Htr2c Htr2c Tnf Tnf Itgb1 Itgb1 Adora2a Adora2a Htr1b Htr1b Gabbr1 Gabbr1 I79_015084 I79_015084 I79_014994 I79_014994 Stxbp1 Stxbp1 Gopc Gopc I79_014543 I79_014543 Htr6 Htr6 Slc43a1 Slc43a1 Mapk9 Mapk9 Dpysl2 Dpysl2 Psen1 Psen1 Grin2b Grin2b I79_011428 I79_011428 I79_011427 I79_011427 I79_011426 I79_011426 I79_010620 I79_010620 Arl6ip1 Arl6ip1 P2ry2 P2ry2 Trh Trh Arl6ip5 Arl6ip5 Grik1 Grik1 I79_001236 I79_001236 Dtnbp1 Dtnbp1 Fgf23 Fgf23 Stc1 Stc1 Sfrp4 Sfrp4 Abat Abat Pla2g10 Pla2g10 Pla2g4a Pla2g4a Agt Agt Slc6a1 Slc6a1 Cry2 Cry2 Lep Lep I79_003347 I79_003347 Edn1 Edn1 Grk6 Grk6 Slc34a1 Slc34a1 I79_003906 I79_003906 Hrh2 Hrh2 I79_004031 I79_004031 Arg2 Arg2 Slc10a1 Slc10a1 Ptafr Ptafr I79_004285 I79_004285 I79_004475 I79_004475 Pdzk1 Pdzk1 Sv2a Sv2a Adora1 Adora1 Prnp Prnp Rgs2 Rgs2 Septin2 Septin2 I79_005455 I79_005455 I79_005534 I79_005534 Ca7 Ca7 Hk1 Hk1 I79_006234 I79_006234 I79_006547 I79_006547 Grm2 Grm2 I79_006708 I79_006708 Cck Cck I79_007067 I79_007067 Avpr1a Avpr1a Tnfsf11 Tnfsf11 Hrh3 Hrh3 Ntsr1 Ntsr1 I79_009987 I79_009987 H671_xg20748 H671_xg20748 Prkaa1 Prkaa1 Syk Syk I79_010458 I79_010458 Prkg2 Prkg2 Ahcyl1 Ahcyl1 Il1rn Il1rn Atf4 Atf4 Ptges Ptges Ripk1 Ripk1 Mtor Mtor I79_022023 I79_022023 Sigirr Sigirr I79_019630 I79_019630 I79_019629 I79_019629 I79_019626 I79_019626 I79_019625 I79_019625 I79_019537 I79_019537 Npy5r Npy5r I79_019158 I79_019158 Syt4 Syt4 Rab11b Rab11b I79_018763 I79_018763
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_018761Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (448 aa)
I79_018661Metabotropic glutamate receptor 5. (275 aa)
Agtr2Type-2 angiotensin II receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
Sstr4Somatostatin receptor type 4; Belongs to the G-protein coupled receptor 1 family. (384 aa)
Slc43a2Large neutral amino acids transporter small subunit 4. (217 aa)
Pla2g685 kDa calcium-independent phospholipase A2. (77 aa)
I79_017861Solute carrier family 12 member 2. (706 aa)
I79_017638Transient receptor potential cation channel subfamily A member 1. (312 aa)
I79_017637Transient receptor potential cation channel subfamily A member 1. (291 aa)
Per2Period circadian protein-like 2. (1262 aa)
Pla2g3Group 3 secretory phospholipase A2. (398 aa)
Htr1a5-hydroxytryptamine receptor 1A. (422 aa)
I79_018762Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (370 aa)
Htr2c5-hydroxytryptamine receptor 2C. (317 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Adora2aAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
Htr1b5-hydroxytryptamine receptor 1B. (386 aa)
Gabbr1Gamma-aminobutyric acid type B receptor subunit 1. (401 aa)
I79_015084Gamma-aminobutyric acid type B receptor subunit 1. (281 aa)
I79_014994Vesicular glutamate transporter 3. (461 aa)
Stxbp1Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (385 aa)
GopcGolgi-associated PDZ and coiled-coil motif-containing protein. (424 aa)
I79_014543Proto-oncogene tyrosine-protein kinase ROS. (1548 aa)
Htr65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (406 aa)
Slc43a1Large neutral amino acids transporter small subunit 3. (607 aa)
Mapk9Mitogen-activated protein kinase 9. (303 aa)
Dpysl2Dihydropyrimidinase-related protein 2. (572 aa)
Psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
Grin2bGlutamate [NMDA] receptor subunit epsilon-2. (1373 aa)
I79_011428Protein FAM115A. (882 aa)
I79_011427Protein FAM115C. (564 aa)
I79_011426Experimental autoimmune prostatitis antigen 2-like. (649 aa)
I79_010620Alpha-synuclein; Belongs to the synuclein family. (166 aa)
Arl6ip1ADP-ribosylation factor-like protein 6-interacting protein 1. (203 aa)
P2ry2p2Y purinoceptor 2; Belongs to the G-protein coupled receptor 1 family. (151 aa)
TrhPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (247 aa)
Arl6ip5PRA1 family protein. (188 aa)
Grik1Glutamate receptor, ionotropic kainate 1. (778 aa)
I79_001236Bile salt export pump. (1096 aa)
Dtnbp1Dysbindin. (125 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Stc1Stanniocalcin-1. (247 aa)
Sfrp4Secreted frizzled-related protein 4. (348 aa)
Abat4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
Pla2g10Phospholipase A(2). (140 aa)
Pla2g4aPhospholipase A2. (749 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
Slc6a1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
Cry2Cryptochrome-2. (577 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_003347Rab3 GTPase-activating protein catalytic subunit. (748 aa)
Edn1Endothelin-1. (202 aa)
Grk6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (551 aa)
Slc34a1Sodium-dependent phosphate transport protein 2A. (629 aa)
I79_003906Fibroblast growth factor receptor 4. (1040 aa)
Hrh2Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (358 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
Arg2Arginase. (305 aa)
Slc10a1Sodium/bile acid cotransporter. (317 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
I79_004285p2X purinoceptor 7. (805 aa)
I79_004475Carbonic anhydrase 2. (220 aa)
Pdzk1Na(+)/H(+) exchange regulatory cofactor NHE-RF3. (523 aa)
Sv2aSynaptic vesicle glycoprotein 2A. (742 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PrnpMajor prion protein; Belongs to the prion family. (254 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
Septin2Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (321 aa)
I79_005455Proton-coupled amino acid transporter 2. (480 aa)
I79_005534Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1145 aa)
Ca7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (208 aa)
Hk1Hexokinase-1. (917 aa)
I79_006234Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (161 aa)
I79_006547Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (311 aa)
Grm2Metabotropic glutamate receptor 2. (916 aa)
I79_006708Secretory phospholipase A2 receptor. (593 aa)
CckCholecystokinin. (115 aa)
I79_007067Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1107 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
Hrh3Histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
Ntsr1Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
I79_009987Collectrin. (118 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
Prkaa1Non-specific serine/threonine protein kinase. (477 aa)
SykTyrosine-protein kinase. (611 aa)
I79_010458Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (451 aa)
Prkg2cGMP-dependent protein kinase 2. (546 aa)
Ahcyl1Adenosylhomocysteinase. (646 aa)
Il1rnInterleukin-1. (157 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
PtgesProstaglandin E synthase. (150 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
SigirrAnoctamin. (1092 aa)
I79_019630Liver carboxylesterase 1; Belongs to the type-B carboxylesterase/lipase family. (765 aa)
I79_019629Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (564 aa)
I79_019626Liver carboxylesterase 4. (105 aa)
I79_019625Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (514 aa)
I79_019537Metabotropic glutamate receptor 5. (297 aa)
Npy5rNeuropeptide Y receptor type 5-like protein. (466 aa)
I79_019158Gamma-aminobutyric acid receptor subunit epsilon; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (360 aa)
Syt4Synaptotagmin-4. (243 aa)
Rab11bRas-related protein Rab-11B. (218 aa)
I79_018763Liver carboxylesterase 4. (393 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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