(23 nodes) Response to leptin network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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gene neighborhood

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Your Input:
	Adipor1	Adiponectin receptor protein 1. (375 aa)
	Ebi3	Interleukin-27 subunit beta. (228 aa)
	I79_008980	Bardet-Biedl syndrome 4 protein-like. (104 aa)
	Bbs4	Bardet-Biedl syndrome 4 protein-like. (125 aa)
	I79_010469	Bardet-Biedl syndrome 2 protein-like. (594 aa)
	I79_010470	Metallothionein-3; Belongs to the metallothionein superfamily. Type 1 family. (108 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Gck	Phosphotransferase. (465 aa)
	Ugcg	Ceramide glucosyltransferase. (236 aa)
	I79_013437	Nuclear receptor subfamily 4 group A member 3. (598 aa)
	I79_015980	Leptin receptor. (533 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	Nr1d1	Nuclear receptor subfamily 1 group D member 1. (508 aa)
	Pid1	PTB-containing, cubilin and LRP1-interacting protein. (159 aa)
	I79_025745	Nuclear receptor subfamily 1 group D member 1. (226 aa)
	I79_000430	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (533 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	Fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Edn1	Endothelin-1. (202 aa)
	Fgb	Fibrinogen beta chain. (407 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipor1	I79_015980	G3H3L5	G3HY62	Adiponectin receptor protein 1.	Leptin receptor.	0.410
Adipor1	Lep	G3H3L5	G3GZ86	Adiponectin receptor protein 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.705
Bbs4	I79_008980	G3HEJ7	G3HEJ6	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.450
Bbs4	I79_010469	G3HEJ7	G3HIJ8	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 2 protein-like.	0.947
Ccnd1	I79_018586	A5A422	G3I540	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.600
Ccnd1	Lep	A5A422	G3GZ86	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.567
Ccnd1	Sirt1	A5A422	G3HAB1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	NAD-dependent deacetylase sirtuin-1.	0.514
Ccnd1	Stat3	A5A422	G3HLW9	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.874
Edn1	Lep	G3H0G9	G3GZ86	Endothelin-1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.548
Edn1	Stat3	G3H0G9	G3HLW9	Endothelin-1.	Signal transducer and activator of transcription.	0.402
Fgf23	Lep	G3GUK1	G3GZ86	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.443
Gck	I79_015980	G3HMA6	G3HY62	Phosphotransferase.	Leptin receptor.	0.408
Gck	Lep	G3HMA6	G3GZ86	Phosphotransferase.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.456
I79_000430	I79_010469	G3GSB1	G3HIJ8	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.	Bardet-Biedl syndrome 2 protein-like.	0.424
I79_008980	Bbs4	G3HEJ6	G3HEJ7	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.450
I79_008980	I79_010469	G3HEJ6	G3HIJ8	Bardet-Biedl syndrome 4 protein-like.	Bardet-Biedl syndrome 2 protein-like.	0.947
I79_010469	Bbs4	G3HIJ8	G3HEJ7	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.947
I79_010469	I79_000430	G3HIJ8	G3GSB1	Bardet-Biedl syndrome 2 protein-like.	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.	0.424
I79_010469	I79_008980	G3HIJ8	G3HEJ6	Bardet-Biedl syndrome 2 protein-like.	Bardet-Biedl syndrome 4 protein-like.	0.947
I79_015980	Adipor1	G3HY62	G3H3L5	Leptin receptor.	Adiponectin receptor protein 1.	0.410