STRINGSTRING
I79_006881 I79_006881 Gjb2 Gjb2 Mst1 Mst1 I79_006650 I79_006650 Adipor2 Adipor2 I79_006442 I79_006442 Maged2 Maged2 I79_006416 I79_006416 Prdx3 Prdx3 Nodal Nodal Ghsr Ghsr Epor Epor Med1 Med1 Adcy7 Adcy7 Rgs2 Rgs2 Igfbp5 Igfbp5 Igfbp2 Igfbp2 Akt1 Akt1 Crhbp Crhbp Ptafr Ptafr Oxtr Oxtr Mmp2 Mmp2 Tacr1 Tacr1 Ctsb Ctsb Edn1 Edn1 Adra2b Adra2b Polr1b Polr1b I79_003312 I79_003312 Csmd1 Csmd1 Lep Lep Bmpr2 Bmpr2 Ucn Ucn Tcf23 Tcf23 Slc22a16 Slc22a16 Ghrl Ghrl Agt Agt I79_002264 I79_002264 Ptgs2 Ptgs2 Pla2g4a Pla2g4a Emp2 Emp2 I79_002035 I79_002035 Pmp22 Pmp22 Tgfbr2 Tgfbr2 Stc1 Stc1 I79_001487 I79_001487 Tead4 Tead4 Fkbp4 Fkbp4 I79_001328 I79_001328 Sp3 Sp3 CgPICR_003438 CgPICR_003438 I79_000761 I79_000761 Stox2 Stox2 I79_000682 I79_000682 I79_000677 I79_000677 I79_000658 I79_000658 Umps Umps I79_000054 I79_000054 I79_000024 I79_000024 Gja1 Gja1 I79_025795 I79_025795 I79_025606 I79_025606 I79_025440 I79_025440 Serpine2 Serpine2 I79_025229 I79_025229 CgPICR_017245 CgPICR_017245 I79_025003 I79_025003 I79_024946 I79_024946 I79_024944 I79_024944 Endou Endou I79_024535 I79_024535 Pla2g6 Pla2g6 Fut7 Fut7 I79_023816 I79_023816 I79_023605 I79_023605 I79_023594 I79_023594 Nppa Nppa Klk14 Klk14 I79_023125 I79_023125 Ar Ar Fbln1 Fbln1 I79_022667 I79_022667 Exoc1 Exoc1 I79_022305 I79_022305 Testin-2 Testin-2 Mtor Mtor I79_022023 I79_022023 Vdr Vdr Rxra Rxra Reck Reck I79_020843 I79_020843 Tgfb1 Tgfb1 Ucp3 Ucp3 Prdm14 Prdm14 I79_019286 I79_019286 Adra2a Adra2a Men1 Men1 Itga5 Itga5 Epo Epo I79_018862 I79_018862 Cuzd1 Cuzd1 I79_018785 I79_018785 I79_018776 I79_018776 Slc38a2 Slc38a2 Ndp Ndp Mapk3 Mapk3 I79_018056 I79_018056 I79_018055 I79_018055 CgPICR_009833 CgPICR_009833 I79_018053 I79_018053 I79_018052 I79_018052 I79_018050 I79_018050 Trim28 Trim28 Fosl1 Fosl1 Lamb1 Lamb1 I79_017352 I79_017352 Eddm3b Eddm3b Pappa Pappa Lif Lif I79_016941 I79_016941 I79_016834 I79_016834 I79_016832 I79_016832 I79_016831 I79_016831 I79_016830 I79_016830 I79_016829 I79_016829 H671_1g1119 H671_1g1119 CgPICR_005625 CgPICR_005625 Hsd11b2 Hsd11b2 Tppp3 Tppp3 Arid1a Arid1a Adm Adm Acvr2a Acvr2a I79_015916 I79_015916 Tmed2 Tmed2 Commd8 Commd8 I79_015356 I79_015356 Ihh Ihh A1cf A1cf I79_015207 I79_015207 Prdm1 Prdm1 I79_014844 I79_014844 Sp1 Sp1 I79_014809 I79_014809 I79_014329 I79_014329 Itgb4 Itgb4 I79_014326 I79_014326 I79_014325 I79_014325 I79_013946 I79_013946 Tle6 Tle6 I79_013771 I79_013771 I79_013721 I79_013721 Ppard Ppard Slc6a4 Slc6a4 Rxrb Rxrb Ddr1 Ddr1 I79_013032 I79_013032 Kiss1 Kiss1 Tgm4 Tgm4 Atp7a Atp7a Acsl4 Acsl4 I79_011937 I79_011937 I79_011936 I79_011936 I79_011712 I79_011712 I79_011711 I79_011711 Grn Grn Cbs Cbs Cdh1 Cdh1 Itga3 Itga3 I79_010883 I79_010883 I79_010700 I79_010700 Wnt4 Wnt4 Acod1 Acod1 H671_xg20748 H671_xg20748 Ooep Ooep Itgb3 Itgb3 I79_009500 I79_009500 Tgfb3 Tgfb3 Pgf Pgf Slc2a1 Slc2a1 Dazap1 Dazap1 I79_009191 I79_009191 Ptgis Ptgis Comt Comt Hfe Hfe I79_007986 I79_007986 Ash1l Ash1l Ube2q1 Ube2q1 I79_007917 I79_007917 Angpt2 Angpt2 I79_007744 I79_007744 Ptn Ptn Stc2 Stc2 Avpr1a Avpr1a Mmp9 Mmp9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_006881CUB and sushi domain-containing protein 2. (3527 aa)
Gjb2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
Mst1Hepatocyte growth factor-like protein. (88 aa)
I79_006650Hepatocyte growth factor-like protein. (93 aa)
Adipor2Adiponectin receptor protein 2. (386 aa)
I79_006442Relaxin receptor 1. (770 aa)
Maged2Melanoma-associated antigen D2. (628 aa)
I79_006416Histone H3.3. (117 aa)
Prdx3Thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
NodalNodal. (309 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
EporErythropoietin receptor. (479 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
Adcy7Adenylate cyclase type 7. (694 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Igfbp2Insulin-like growth factor-binding protein 2. (177 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CrhbpCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (353 aa)
Mmp272 kDa type IV collagenase. (662 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
Edn1Endothelin-1. (202 aa)
Adra2bAlpha-2B adrenergic receptor. (449 aa)
Polr1bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (996 aa)
I79_003312CUB and sushi domain-containing protein 1. (3110 aa)
Csmd1CUB and sushi domain-containing protein 1. (106 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
UcnUrocortin. (122 aa)
Tcf23Transcription factor 23. (278 aa)
Slc22a16Solute carrier family 22 member 16. (773 aa)
GhrlAppetite-regulating hormone. (100 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
I79_002264Histone H3.3 type 1. (138 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Pla2g4aPhospholipase A2. (749 aa)
Emp2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
I79_002035Alpha-2C adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (230 aa)
Pmp22Peripheral myelin protein 22. (92 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Stc1Stanniocalcin-1. (247 aa)
I79_001487Progesterone receptor. (741 aa)
Tead4Transcriptional enhancer factor TEF-3. (361 aa)
Fkbp4Peptidylprolyl isomerase. (411 aa)
I79_001328NACHT, LRR and PYD domains-containing protein 5. (160 aa)
Sp3Transcription factor Sp3. (338 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
I79_000761Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
Stox2Storkhead-box protein 2. (81 aa)
I79_000682Histone H3.3. (136 aa)
I79_000677Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
I79_000658Kalirin. (2681 aa)
UmpsUridine 5'-monophosphate synthase. (480 aa)
I79_000054Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (668 aa)
I79_000024Aldo-keto reductase family 1 member C18. (219 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
I79_025795Vitamin D3 receptor. (86 aa)
I79_025606Proteoglycan 4. (101 aa)
I79_025440Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
Serpine2Glia-derived nexin; Belongs to the serpin family. (189 aa)
I79_025229Upstream-binding factor 1-like protein 1. (329 aa)
CgPICR_017245Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
I79_025003Upstream-binding factor 1-like protein 1. (349 aa)
I79_024946NACHT, LRR and PYD domains-containing protein 5. (626 aa)
I79_024944NACHT, LRR and PYD domains-containing protein 5. (98 aa)
EndouPlacental protein 11. (241 aa)
I79_024535Protein FAM127C. (132 aa)
Pla2g685 kDa calcium-independent phospholipase A2. (77 aa)
Fut7Alpha-(1,3)-fucosyltransferase. (342 aa)
I79_023816Proprotein convertase subtilisin/kexin type 5. (306 aa)
I79_023605Histone H3.3. (136 aa)
I79_023594Atrial natriuretic peptide-converting enzyme. (271 aa)
NppaAtrial natriuretic factor. (362 aa)
Klk14Kallikrein-14; Belongs to the peptidase S1 family. (236 aa)
I79_023125Proprotein convertase subtilisin/kexin type 5. (661 aa)
ArAndrogen receptor. (517 aa)
Fbln1Fibulin-1. (156 aa)
I79_022667Fibulin-1. (628 aa)
Exoc1Exocyst complex component 1-like protein. (880 aa)
I79_022305Proprotein convertase subtilisin/kexin type 5. (170 aa)
Testin-2Testin-2; Belongs to the peptidase C1 family. (401 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
VdrVitamin D3 receptor. (372 aa)
RxraRetinoic acid receptor RXR-alpha. (439 aa)
ReckReversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
I79_020843Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Ucp3Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (650 aa)
Prdm14PR domain zinc finger protein 14. (564 aa)
I79_019286Androgen receptor. (295 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
Men1Menin. (610 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (729 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
I79_018862Homeobox protein HMX3. (257 aa)
Cuzd1CUB and zona pellucida-like domain-containing protein 1. (442 aa)
I79_018785Retinoic acid receptor alpha. (484 aa)
I79_018776Sodium-coupled neutral amino acid transporter 1. (436 aa)
Slc38a2Sodium-coupled neutral amino acid transporter 2. (504 aa)
NdpNorrin. (113 aa)
Mapk3Mitogen-activated protein kinase. (408 aa)
I79_018056Prolactin-3D4. (83 aa)
I79_018055Prolactin-6A1. (146 aa)
CgPICR_009833Prolactin-3B1. (216 aa)
I79_018053Prolactin-3B1. (114 aa)
I79_018052Prolactin-3D4. (185 aa)
I79_018050Prolactin-3D4. (172 aa)
Trim28Transcription intermediary factor 1-beta. (535 aa)
Fosl1Fos-related antigen 1. (279 aa)
Lamb1Laminin subunit beta-1. (1617 aa)
I79_017352ATP-binding cassette transporter sub-family C member 8. (2352 aa)
Eddm3bEpididymal secretory protein E3-beta; Belongs to the pancreatic ribonuclease family. (342 aa)
PappaPappalysin-1. (1506 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
I79_016941Histone H3.3. (114 aa)
I79_016834Cytochrome P450 2D4; Belongs to the cytochrome P450 family. (500 aa)
I79_016832Cytochrome P450 2D27; Belongs to the cytochrome P450 family. (177 aa)
I79_016831Cytochrome P450 2D20; Belongs to the cytochrome P450 family. (373 aa)
I79_016830Cytochrome P450 2D26. (124 aa)
I79_016829Cytochrome P450 2D27; Belongs to the cytochrome P450 family. (464 aa)
H671_1g111915-hydroxyprostaglandin dehydrogenase [NAD+]-like protein. (208 aa)
CgPICR_005625Agouti-related protein. (131 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2. (312 aa)
Tppp3Tubulin polymerization-promoting protein family member 3. (176 aa)
Arid1aAT-rich interactive domain-containing protein 1A. (1892 aa)
AdmProcalcitonin/adrenomedullin containing protein. (184 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Tmed2Transmembrane emp24 domain-containing protein 2. (116 aa)
Commd8Atrial natriuretic peptide-converting enzyme. (632 aa)
I79_015356Heat shock factor protein 1. (524 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
A1cfAPOBEC1 complementation factor. (1001 aa)
I79_01520725-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
Prdm1PR domain zinc finger protein 1. (825 aa)
I79_014844Histone H3.3. (140 aa)
Sp1Transcription factor Sp1. (778 aa)
I79_014809Histone H3.3 type 1. (89 aa)
I79_014329Histone H3.3. (102 aa)
Itgb4Integrin beta-4. (650 aa)
I79_014326Integrin beta-4. (157 aa)
I79_014325Integrin beta-4. (117 aa)
I79_013946Long-chain-fatty-acid--CoA ligase 4. (289 aa)
Tle6Transducin-like enhancer protein 6. (530 aa)
I79_013771Calcitonin. (206 aa)
I79_013721P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (360 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
Slc6a4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (520 aa)
RxrbRetinoic acid receptor RXR-beta. (101 aa)
Ddr1Epithelial discoidin domain-containing receptor 1 isoform 1. (910 aa)
I79_013032Peptidyl-glycine alpha-amidating monooxygenase B. (851 aa)
Kiss1Metastasis-suppressor KiSS-1. (262 aa)
Tgm4Protein-glutamine gamma-glutamyltransferase 4. (624 aa)
Atp7aCopper-transporting ATPase 1. (1457 aa)
Acsl4Long-chain-fatty-acid--CoA ligase 4. (274 aa)
I79_011937Prolactin-5A1. (252 aa)
I79_011936Prolactin-7A2. (148 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
GrnGranulins. (592 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
Itga3Integrin alpha-3; Belongs to the integrin alpha chain family. (1051 aa)
I79_010883Gastric inhibitory polypeptide. (205 aa)
I79_010700Transcription factor Sp3. (441 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
Acod1Immune-responsive gene 1 protein. (290 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
OoepOocyte-expressed protein-like. (129 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
I79_009500Mitogen-activated protein kinase 1. (68 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
Slc2a1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
Dazap1DAZ-associated protein 1. (365 aa)
I79_009191Basigin. (437 aa)
PtgisProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
HfeHereditary hemochromatosis protein-like; Belongs to the MHC class I family. (306 aa)
I79_007986Putative histone-lysine N-methyltransferase ASH1L. (455 aa)
Ash1lPutative histone-lysine N-methyltransferase ASH1L. (1546 aa)
Ube2q1Ubiquitin-conjugating enzyme E2 Q1. (761 aa)
I79_007917Serine protease 29; Belongs to the peptidase S1 family. (279 aa)
Angpt2Angiopoietin-2. (288 aa)
I79_007744Angiopoietin-2. (188 aa)
PtnPleiotrophin. (168 aa)
Stc2Stanniocalcin-2. (297 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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