STRINGSTRING
Nppa Nppa Acr Acr Klk14 Klk14 I79_023125 I79_023125 Ar Ar Fbln1 Fbln1 I79_022667 I79_022667 Exoc1 Exoc1 I79_022305 I79_022305 Testin-2 Testin-2 Mtor Mtor I79_022023 I79_022023 Vdr Vdr Rxra Rxra I79_021538 I79_021538 Reck Reck I79_020843 I79_020843 Tgfb1 Tgfb1 Ucp3 Ucp3 B4galt1 B4galt1 Prdm14 Prdm14 I79_019286 I79_019286 Adra2a Adra2a Men1 Men1 Itga5 Itga5 Epo Epo I79_018862 I79_018862 Cuzd1 Cuzd1 I79_018785 I79_018785 I79_018776 I79_018776 Slc38a2 Slc38a2 Ndp Ndp Mapk3 Mapk3 Tbxt Tbxt I79_018056 I79_018056 I79_018055 I79_018055 CgPICR_009833 CgPICR_009833 I79_018053 I79_018053 I79_018052 I79_018052 I79_018050 I79_018050 Trim28 Trim28 Fosl1 Fosl1 Lamb1 Lamb1 I79_017352 I79_017352 Eddm3b Eddm3b Pappa Pappa Lif Lif I79_016941 I79_016941 I79_016832 I79_016832 I79_016834 I79_016834 I79_016831 I79_016831 I79_016830 I79_016830 I79_016829 I79_016829 Dkkl1 Dkkl1 H671_1g1119 H671_1g1119 CgPICR_005625 CgPICR_005625 Hsd11b2 Hsd11b2 Tppp3 Tppp3 I79_000024 I79_000024 I79_000054 I79_000054 Umps Umps I79_000658 I79_000658 I79_000677 I79_000677 I79_000682 I79_000682 Stox2 Stox2 I79_000761 I79_000761 CgPICR_003438 CgPICR_003438 Sp3 Sp3 I79_001328 I79_001328 Fkbp4 Fkbp4 Tead4 Tead4 I79_001487 I79_001487 Stc1 Stc1 Tgfbr2 Tgfbr2 I79_001759 I79_001759 I79_002035 I79_002035 Emp2 Emp2 Pla2g4a Pla2g4a Ptgs2 Ptgs2 I79_002264 I79_002264 Agt Agt Ghrl Ghrl Slc22a16 Slc22a16 Tcf23 Tcf23 Ucn Ucn Bmpr2 Bmpr2 Lep Lep Csmd1 Csmd1 I79_003312 I79_003312 Polr1b Polr1b Adra2b Adra2b Edn1 Edn1 Ctsb Ctsb Tacr1 Tacr1 Mmp2 Mmp2 Oxtr Oxtr Ptafr Ptafr Crhbp Crhbp Akt1 Akt1 Igfbp2 Igfbp2 Igfbp5 Igfbp5 Rgs2 Rgs2 Adcy7 Adcy7 Med1 Med1 Epor Epor Ghsr Ghsr Nodal Nodal Prdx3 Prdx3 I79_006416 I79_006416 Maged2 Maged2 I79_006442 I79_006442 Adipor2 Adipor2 I79_006650 I79_006650 Mst1 Mst1 Gjb2 Gjb2 Mmp9 Mmp9 I79_006881 I79_006881 Avpr1a Avpr1a Sh3pxd2b Sh3pxd2b Stc2 Stc2 Ptn Ptn I79_007744 I79_007744 Angpt2 Angpt2 Tekt4 Tekt4 I79_007917 I79_007917 Ube2q1 Ube2q1 Ash1l Ash1l I79_007986 I79_007986 Hfe Hfe Comt Comt Ptgis Ptgis I79_009191 I79_009191 Dazap1 Dazap1 Slc2a1 Slc2a1 Pgf Pgf Tgfb3 Tgfb3 I79_009500 I79_009500 Itgb3 Itgb3 Ooep Ooep H671_xg20748 H671_xg20748 Acod1 Acod1 Wnt4 Wnt4 I79_010700 I79_010700 I79_010883 I79_010883 Itga3 Itga3 Cdh1 Cdh1 Cbs Cbs Grn Grn I79_011711 I79_011711 I79_011712 I79_011712 I79_011936 I79_011936 I79_011937 I79_011937 Acsl4 Acsl4 Atp7a Atp7a Tgm4 Tgm4 Kiss1 Kiss1 I79_013032 I79_013032 Ddr1 Ddr1 Rxrb Rxrb Slc6a4 Slc6a4 Ppard Ppard I79_013721 I79_013721 I79_013771 I79_013771 Tle6 Tle6 I79_013946 I79_013946 I79_014325 I79_014325 I79_014326 I79_014326 Itgb4 Itgb4 I79_014329 I79_014329 I79_014809 I79_014809 Sp1 Sp1 I79_014844 I79_014844 Prdm1 Prdm1 I79_015207 I79_015207 A1cf A1cf Ihh Ihh I79_015356 I79_015356 Commd8 Commd8 Tmed2 Tmed2 I79_015798 I79_015798 I79_015800 I79_015800 I79_015916 I79_015916 Acvr2a Acvr2a Adm Adm Arid1a Arid1a Gja1 Gja1 I79_025795 I79_025795 I79_025606 I79_025606 I79_025440 I79_025440 Serpine2 Serpine2 I79_025229 I79_025229 I79_025216 I79_025216 CgPICR_017245 CgPICR_017245 I79_025003 I79_025003 I79_024946 I79_024946 I79_024944 I79_024944 Endou Endou I79_024535 I79_024535 Pla2g6 Pla2g6 Fut7 Fut7 I79_023816 I79_023816 I79_023605 I79_023605 I79_023594 I79_023594
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NppaAtrial natriuretic factor. (362 aa)
AcrAcrosin; Belongs to the peptidase S1 family. (286 aa)
Klk14Kallikrein-14; Belongs to the peptidase S1 family. (236 aa)
I79_023125Proprotein convertase subtilisin/kexin type 5. (661 aa)
ArAndrogen receptor. (517 aa)
Fbln1Fibulin-1. (156 aa)
I79_022667Fibulin-1. (628 aa)
Exoc1Exocyst complex component 1-like protein. (880 aa)
I79_022305Proprotein convertase subtilisin/kexin type 5. (170 aa)
Testin-2Testin-2; Belongs to the peptidase C1 family. (401 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
VdrVitamin D3 receptor. (372 aa)
RxraRetinoic acid receptor RXR-alpha. (439 aa)
I79_021538Brachyury protein. (242 aa)
ReckReversion-inducing cysteine-rich protein with Kazal motifs. (714 aa)
I79_020843Reversion-inducing cysteine-rich protein with Kazal motifs. (107 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Ucp3Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (650 aa)
B4galt1Beta-1,4-galactosyltransferase 1. (258 aa)
Prdm14PR domain zinc finger protein 14. (564 aa)
I79_019286Androgen receptor. (295 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
Men1Menin. (610 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (729 aa)
EpoErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
I79_018862Homeobox protein HMX3. (257 aa)
Cuzd1CUB and zona pellucida-like domain-containing protein 1. (442 aa)
I79_018785Retinoic acid receptor alpha. (484 aa)
I79_018776Sodium-coupled neutral amino acid transporter 1. (436 aa)
Slc38a2Sodium-coupled neutral amino acid transporter 2. (504 aa)
NdpNorrin. (113 aa)
Mapk3Mitogen-activated protein kinase. (408 aa)
TbxtBrachyury protein. (223 aa)
I79_018056Prolactin-3D4. (83 aa)
I79_018055Prolactin-6A1. (146 aa)
CgPICR_009833Prolactin-3B1. (216 aa)
I79_018053Prolactin-3B1. (114 aa)
I79_018052Prolactin-3D4. (185 aa)
I79_018050Prolactin-3D4. (172 aa)
Trim28Transcription intermediary factor 1-beta. (535 aa)
Fosl1Fos-related antigen 1. (279 aa)
Lamb1Laminin subunit beta-1. (1617 aa)
I79_017352ATP-binding cassette transporter sub-family C member 8. (2352 aa)
Eddm3bEpididymal secretory protein E3-beta; Belongs to the pancreatic ribonuclease family. (342 aa)
PappaPappalysin-1. (1506 aa)
LifLeukemia inhibitory factor-like protein. (158 aa)
I79_016941Histone H3.3. (114 aa)
I79_016832Cytochrome P450 2D27; Belongs to the cytochrome P450 family. (177 aa)
I79_016834Cytochrome P450 2D4; Belongs to the cytochrome P450 family. (500 aa)
I79_016831Cytochrome P450 2D20; Belongs to the cytochrome P450 family. (373 aa)
I79_016830Cytochrome P450 2D26. (124 aa)
I79_016829Cytochrome P450 2D27; Belongs to the cytochrome P450 family. (464 aa)
Dkkl1Dickkopf-like protein 1. (230 aa)
H671_1g111915-hydroxyprostaglandin dehydrogenase [NAD+]-like protein. (208 aa)
CgPICR_005625Agouti-related protein. (131 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2. (312 aa)
Tppp3Tubulin polymerization-promoting protein family member 3. (176 aa)
I79_000024Aldo-keto reductase family 1 member C18. (219 aa)
I79_000054Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (668 aa)
UmpsUridine 5'-monophosphate synthase. (480 aa)
I79_000658Kalirin. (2681 aa)
I79_000677Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
I79_000682Histone H3.3. (136 aa)
Stox2Storkhead-box protein 2. (81 aa)
I79_000761Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
Sp3Transcription factor Sp3. (338 aa)
I79_001328NACHT, LRR and PYD domains-containing protein 5. (160 aa)
Fkbp4Peptidylprolyl isomerase. (411 aa)
Tead4Transcriptional enhancer factor TEF-3. (361 aa)
I79_001487Progesterone receptor. (741 aa)
Stc1Stanniocalcin-1. (247 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
I79_001759Tektin 3. (318 aa)
I79_002035Alpha-2C adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (230 aa)
Emp2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
Pla2g4aPhospholipase A2. (749 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
I79_002264Histone H3.3 type 1. (138 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
GhrlAppetite-regulating hormone. (100 aa)
Slc22a16Solute carrier family 22 member 16. (773 aa)
Tcf23Transcription factor 23. (278 aa)
UcnUrocortin. (122 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Csmd1CUB and sushi domain-containing protein 1. (106 aa)
I79_003312CUB and sushi domain-containing protein 1. (3110 aa)
Polr1bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (996 aa)
Adra2bAlpha-2B adrenergic receptor. (449 aa)
Edn1Endothelin-1. (202 aa)
CtsbCathepsin B; Belongs to the peptidase C1 family. (339 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
Mmp272 kDa type IV collagenase. (662 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (353 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CrhbpCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Igfbp2Insulin-like growth factor-binding protein 2. (177 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Rgs2Regulator of G-protein signaling 2. (207 aa)
Adcy7Adenylate cyclase type 7. (694 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
EporErythropoietin receptor. (479 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
NodalNodal. (309 aa)
Prdx3Thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
I79_006416Histone H3.3. (117 aa)
Maged2Melanoma-associated antigen D2. (628 aa)
I79_006442Relaxin receptor 1. (770 aa)
Adipor2Adiponectin receptor protein 2. (386 aa)
I79_006650Hepatocyte growth factor-like protein. (93 aa)
Mst1Hepatocyte growth factor-like protein. (88 aa)
Gjb2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
I79_006881CUB and sushi domain-containing protein 2. (3527 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
Sh3pxd2bSH3 and PX domain-containing protein 2B. (880 aa)
Stc2Stanniocalcin-2. (297 aa)
PtnPleiotrophin. (168 aa)
I79_007744Angiopoietin-2. (188 aa)
Angpt2Angiopoietin-2. (288 aa)
Tekt4Tektin-4. (446 aa)
I79_007917Serine protease 29; Belongs to the peptidase S1 family. (279 aa)
Ube2q1Ubiquitin-conjugating enzyme E2 Q1. (761 aa)
Ash1lPutative histone-lysine N-methyltransferase ASH1L. (1546 aa)
I79_007986Putative histone-lysine N-methyltransferase ASH1L. (455 aa)
HfeHereditary hemochromatosis protein-like; Belongs to the MHC class I family. (306 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
PtgisProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
I79_009191Basigin. (437 aa)
Dazap1DAZ-associated protein 1. (365 aa)
Slc2a1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
I79_009500Mitogen-activated protein kinase 1. (68 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
OoepOocyte-expressed protein-like. (129 aa)
H671_xg20748Angiotensin-converting enzyme. (644 aa)
Acod1Immune-responsive gene 1 protein. (290 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
I79_010700Transcription factor Sp3. (441 aa)
I79_010883Gastric inhibitory polypeptide. (205 aa)
Itga3Integrin alpha-3; Belongs to the integrin alpha chain family. (1051 aa)
Cdh1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
GrnGranulins. (592 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011936Prolactin-7A2. (148 aa)
I79_011937Prolactin-5A1. (252 aa)
Acsl4Long-chain-fatty-acid--CoA ligase 4. (274 aa)
Atp7aCopper-transporting ATPase 1. (1457 aa)
Tgm4Protein-glutamine gamma-glutamyltransferase 4. (624 aa)
Kiss1Metastasis-suppressor KiSS-1. (262 aa)
I79_013032Peptidyl-glycine alpha-amidating monooxygenase B. (851 aa)
Ddr1Epithelial discoidin domain-containing receptor 1 isoform 1. (910 aa)
RxrbRetinoic acid receptor RXR-beta. (101 aa)
Slc6a4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (520 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
I79_013721P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (360 aa)
I79_013771Calcitonin. (206 aa)
Tle6Transducin-like enhancer protein 6. (530 aa)
I79_013946Long-chain-fatty-acid--CoA ligase 4. (289 aa)
I79_014325Integrin beta-4. (117 aa)
I79_014326Integrin beta-4. (157 aa)
Itgb4Integrin beta-4. (650 aa)
I79_014329Histone H3.3. (102 aa)
I79_014809Histone H3.3 type 1. (89 aa)
Sp1Transcription factor Sp1. (778 aa)
I79_014844Histone H3.3. (140 aa)
Prdm1PR domain zinc finger protein 1. (825 aa)
I79_01520725-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
A1cfAPOBEC1 complementation factor. (1001 aa)
IhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
I79_015356Heat shock factor protein 1. (524 aa)
Commd8Atrial natriuretic peptide-converting enzyme. (632 aa)
Tmed2Transmembrane emp24 domain-containing protein 2. (116 aa)
I79_015798Beta-hexosaminidase subunit beta. (96 aa)
I79_015800Beta-hexosaminidase. (527 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
AdmProcalcitonin/adrenomedullin containing protein. (184 aa)
Arid1aAT-rich interactive domain-containing protein 1A. (1892 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
I79_025795Vitamin D3 receptor. (86 aa)
I79_025606Proteoglycan 4. (101 aa)
I79_025440Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
Serpine2Glia-derived nexin; Belongs to the serpin family. (189 aa)
I79_025229Upstream-binding factor 1-like protein 1. (329 aa)
I79_025216Beta-hexosaminidase subunit beta. (74 aa)
CgPICR_017245Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
I79_025003Upstream-binding factor 1-like protein 1. (349 aa)
I79_024946NACHT, LRR and PYD domains-containing protein 5. (626 aa)
I79_024944NACHT, LRR and PYD domains-containing protein 5. (98 aa)
EndouPlacental protein 11. (241 aa)
I79_024535Protein FAM127C. (132 aa)
Pla2g685 kDa calcium-independent phospholipase A2. (77 aa)
Fut7Alpha-(1,3)-fucosyltransferase. (342 aa)
I79_023816Proprotein convertase subtilisin/kexin type 5. (306 aa)
I79_023605Histone H3.3. (136 aa)
I79_023594Atrial natriuretic peptide-converting enzyme. (271 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (24%) [HD]