(44 nodes) T cell selection network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	I79_001680	Caspase recruitment domain-containing protein 11. (1089 aa)
	I79_001953	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (763 aa)
	Irf4	Interferon regulatory factor 4. (418 aa)
	I79_002793	Traf2 and NCK-interacting protein kinase. (160 aa)
	I79_002794	Misshapen-like kinase 1. (851 aa)
	Cd28	T-cell-specific surface glycoprotein CD28. (100 aa)
	I79_004087	Tyrosine-protein kinase. (593 aa)
	I79_004721	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1234 aa)
	I79_005603	Putative ubiquitin carboxyl-terminal hydrolase CYLD. (730 aa)
	Tbx21	T-box transcription factor TBX21. (365 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006854	Autoimmune regulator. (606 aa)
	Il6r	Interleukin-6 receptor subunit alpha. (505 aa)
	Stk11	Serine/threonine-protein kinase 11. (505 aa)
	Batf	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	I79_009740	B-Raf proto-oncogene serine/threonine-protein kinase. (229 aa)
	Syk	Tyrosine-protein kinase. (611 aa)
	Bcl11b	B-cell lymphoma/leukemia 11B. (812 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	I79_011202	T-cell surface glycoprotein CD1d1. (111 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_012384	Leukocyte common antigen. (962 aa)
	I79_013182	Class II histocompatibility antigen, M alpha chain; Belongs to the MHC class II family. (261 aa)
	H671_3g9857	Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6. (124 aa)
	Cd74	H-2 class II histocompatibility antigen gamma chain. (329 aa)
	I79_014206	Dedicator of cytokinesis protein 2. (785 aa)
	Itpkb	Kinase; Belongs to the inositol phosphokinase (IPK) family. (789 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	I79_015109	Interleukin-6. (174 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	I79_015244	Thymocyte selection-associated high mobility group box protein TOX. (415 aa)
	Srf	Serum response factor. (361 aa)
	Ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	I79_021702	Dedicator of cytokinesis protein 2. (377 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Testin-2	Testin-2; Belongs to the peptidase C1 family. (401 aa)
	Themis	Protein THEMIS. (591 aa)
	I79_024001	Protein THEMIS. (67 aa)
	Cd3d	T-cell surface glycoprotein CD3 delta chain. (150 aa)
	I79_025440	Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg5	Cd4	G3HVR2	G3GUN9	Autophagy protein 5; Involved in autophagic vesicle formation.	T-cell surface glycoprotein CD4.	0.564
Atg5	Mtor	G3HVR2	G3IEE8	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.587
Batf	Bcl11b	G3HFR9	G3HIW2	Basic leucine zipper transcriptional factor ATF-like.	B-cell lymphoma/leukemia 11B.	0.594
Batf	Cd4	G3HFR9	G3GUN9	Basic leucine zipper transcriptional factor ATF-like.	T-cell surface glycoprotein CD4.	0.734
Batf	Gata3	G3HFR9	G3GR59	Basic leucine zipper transcriptional factor ATF-like.	Trans-acting T-cell-specific transcription factor GATA-3.	0.499
Batf	Irf4	G3HFR9	G3GWW9	Basic leucine zipper transcriptional factor ATF-like.	Interferon regulatory factor 4.	0.849
Batf	Stat3	G3HFR9	G3HLW9	Basic leucine zipper transcriptional factor ATF-like.	Signal transducer and activator of transcription.	0.567
Bcl11b	Batf	G3HIW2	G3HFR9	B-cell lymphoma/leukemia 11B.	Basic leucine zipper transcriptional factor ATF-like.	0.594
Bcl11b	Cd4	G3HIW2	G3GUN9	B-cell lymphoma/leukemia 11B.	T-cell surface glycoprotein CD4.	0.420
Ccr7	Cd28	G3I5N8	G3GYW3	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell-specific surface glycoprotein CD28.	0.525
Ccr7	Cd3d	G3I5N8	G3IMA2	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD3 delta chain.	0.613
Ccr7	Cd4	G3I5N8	G3GUN9	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD4.	0.922
Ccr7	I79_012384	G3I5N8	G3HNP2	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Leukocyte common antigen.	0.553
Ccr7	I79_015109	G3I5N8	G3HVW6	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-6.	0.570
Ccr7	Il15	G3I5N8	G3HJ60	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin; Belongs to the IL-15/IL-21 family.	0.493
Ccr7	Tbx21	G3I5N8	G3H5U9	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-box transcription factor TBX21.	0.550
Cd28	Ccr7	G3GYW3	G3I5N8	T-cell-specific surface glycoprotein CD28.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.525
Cd28	Cd4	G3GYW3	G3GUN9	T-cell-specific surface glycoprotein CD28.	T-cell surface glycoprotein CD4.	0.896
Cd28	I79_001680	G3GYW3	G3GVE3	T-cell-specific surface glycoprotein CD28.	Caspase recruitment domain-containing protein 11.	0.563
Cd28	I79_004087	G3GYW3	G3H1Q5	T-cell-specific surface glycoprotein CD28.	Tyrosine-protein kinase.	0.644