(41 nodes) Cellular extravasation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fer	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	Podxl2	Podocalyxin-like protein 2. (573 aa)
	Itgb2	Integrin beta. (769 aa)
	Ext1	Exostosin-1. (388 aa)
	Chst4	Sulfotransferase; Belongs to the sulfotransferase 1 family. (385 aa)
	I79_008304	Platelet endothelial cell adhesion molecule. (596 aa)
	I79_008633	Integrin alpha-4; Belongs to the integrin alpha chain family. (441 aa)
	I79_008766	Integrin alpha-1; Belongs to the integrin alpha chain family. (1854 aa)
	Madcam1	Mucosal addressin cell adhesion molecule 1. (407 aa)
	I79_009201	Myeloblastin; Belongs to the peptidase S1 family. (211 aa)
	CgPICR_003438	C-C motif chemokine. (143 aa)
	Trim55	Tripartite motif-containing protein 55. (524 aa)
	ICAM1	Intercellular adhesion molecule 1. (527 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	Itgb7	Integrin beta-7. (266 aa)
	I79_025437	Junctional adhesion molecule-like. (340 aa)
	Trem1	Triggering receptor expressed on myeloid cells 1. (92 aa)
	I79_025274	Integrin alpha-L. (331 aa)
	I79_025094	CD99 antigen. (101 aa)
	Itgal	Integrin alpha-L; Belongs to the integrin alpha chain family. (699 aa)
	I79_024443	CD177 antigen. (158 aa)
	I79_024097	Vascular cell adhesion protein 1. (225 aa)
	Cd99l2	CD99 antigen-like protein 2. (102 aa)
	I79_021870	CD177 antigen. (106 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	Crkl	Crk-like protein. (303 aa)
	I79_010364	P-selectin glycoprotein ligand 1. (364 aa)
	Cx3cl1	Fractalkine. (335 aa)
	Golph3	Golgi phosphoprotein 3. (223 aa)
	Cx3cr1	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	Crk	Proto-oncogene C-crk. (327 aa)
	I79_014743	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1071 aa)
	I79_014831	Integrin beta; Belongs to the integrin beta chain family. (721 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	I79_016164	P-selectin. (1330 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Sirpa	Tyrosine-protein phosphatase non-receptor type substrate 1. (522 aa)
	Add2	Beta-adducin. (725 aa)
	Gcnt1	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (428 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccl5	CgPICR_003438	G3I8B1	G3GTT2	C-C motif chemokine.	C-C motif chemokine.	0.964
Ccl5	CgPICR_014700	G3I8B1	G3HWU4	C-C motif chemokine.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.993
Ccl5	Cx3cl1	G3I8B1	G3HIL2	C-C motif chemokine.	Fractalkine.	0.792
Ccl5	Cx3cr1	G3I8B1	G3HQW7	C-C motif chemokine.	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.976
Ccl5	I79_016164	G3I8B1	G3HYM3	C-C motif chemokine.	P-selectin.	0.511
Ccl5	ICAM1	G3I8B1	Q9ERF7	C-C motif chemokine.	Intercellular adhesion molecule 1.	0.646
Ccl5	Itgb2	G3I8B1	G3H8Z5	C-C motif chemokine.	Integrin beta.	0.486
Ccl5	Tnf	G3I8B1	G3HZG9	C-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.759
Ccl5	Vcam1	G3I8B1	G3ID63	C-C motif chemokine.	Vascular cell adhesion protein 1.	0.468
Cd99l2	I79_025094	G3IDY6	G3IMF5	CD99 antigen-like protein 2.	CD99 antigen.	0.647
Cd99l2	ICAM1	G3IDY6	Q9ERF7	CD99 antigen-like protein 2.	Intercellular adhesion molecule 1.	0.522
CgPICR_003438	Ccl5	G3GTT2	G3I8B1	C-C motif chemokine.	C-C motif chemokine.	0.964
CgPICR_003438	CgPICR_014700	G3GTT2	G3HWU4	C-C motif chemokine.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.989
CgPICR_003438	Cx3cl1	G3GTT2	G3HIL2	C-C motif chemokine.	Fractalkine.	0.605
CgPICR_003438	Cx3cr1	G3GTT2	G3HQW7	C-C motif chemokine.	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.901
CgPICR_003438	I79_024097	G3GTT2	G3IJR1	C-C motif chemokine.	Vascular cell adhesion protein 1.	0.503
CgPICR_003438	ICAM1	G3GTT2	Q9ERF7	C-C motif chemokine.	Intercellular adhesion molecule 1.	0.688
CgPICR_003438	Itgb2	G3GTT2	G3H8Z5	C-C motif chemokine.	Integrin beta.	0.526
CgPICR_003438	Lep	G3GTT2	G3GZ86	C-C motif chemokine.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.408
CgPICR_003438	Tnf	G3GTT2	G3HZG9	C-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.711