(44 nodes) Negative regulation of T cell differentiation network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Jak3	Tyrosine-protein kinase JAK3. (222 aa)
	Tmem131l	Transmembrane protein 131-like. (1533 aa)
	Tbx21	T-box transcription factor TBX21. (365 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_007107	Zinc finger protein. (550 aa)
	I79_007264	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (84 aa)
	Zbtb7b	Zinc finger and BTB domain-containing protein 7B. (543 aa)
	Prdx2	Peroxiredoxin-2. (198 aa)
	Zc3h12a	Ribonuclease ZC3H12A. (577 aa)
	I79_011558	Ring finger and CCCH-type zinc finger domain-containing protein 2. (835 aa)
	Runx3	Runt-related transcription factor 3. (299 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	Runx1	Runt-related transcription factor 1. (462 aa)
	Nfkbid	NF-kappa-B inhibitor delta. (74 aa)
	Smad7	Mothers against decapentaplegic-like 7. (256 aa)
	Cd74	H-2 class II histocompatibility antigen gamma chain. (329 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Foxj1	Forkhead box protein J1. (421 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	I79_022036	Peroxiredoxin-2. (108 aa)
	I79_020948	Interferon regulatory factor 1. (369 aa)
	Socs5	Suppressor of cytokine signaling 5. (530 aa)
	I79_019597	Lysyl oxidase-like 3. (797 aa)
	H671_4g12762	Protein deltex-1-like protein. (466 aa)
	Anxa1	Annexin. (346 aa)
	Il4r	Interleukin-4 receptor alpha chain. (835 aa)
	I79_016874	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2. (92 aa)
	Fgl2	Fibroleukin. (613 aa)
	I79_015484	C-type lectin domain family 4 member G. (399 aa)
	Znf16	Zinc finger protein 16. (539 aa)
	Hlx	H2.0-like homeobox protein. (374 aa)
	Bcl6	B-cell lymphoma 6 protein-like. (707 aa)
	I79_001405	Lymphocyte activation gene 3 protein. (345 aa)
	Socs1	Suppressor of cytokine signaling 1. (93 aa)
	Ifnb1	Interferon beta. (182 aa)
	Mdk	Midkine. (160 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Rag2	V(D)J recombination-activating protein 2. (527 aa)
	Tnfsf4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
	Serpinc1	Roquin; Belongs to the serpin family. (1418 aa)
	Zc3h8	Zinc finger CCCH domain-containing protein 8. (306 aa)
	I79_005129	Tyrosine-protein kinase JAK3. (330 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl6	Ctla4	G3GT91	G3GYW4	B-cell lymphoma 6 protein-like.	Cytotoxic T-lymphocyte protein 4.	0.516
Bcl6	Foxp3	G3GT91	G3HNB1	B-cell lymphoma 6 protein-like.	Forkhead box protein P3.	0.763
Bcl6	IL2	G3GT91	G3HTL8	B-cell lymphoma 6 protein-like.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.428
Bcl6	Tbx21	G3GT91	G3H5U9	B-cell lymphoma 6 protein-like.	T-box transcription factor TBX21.	0.600
Ctla4	Bcl6	G3GYW4	G3GT91	Cytotoxic T-lymphocyte protein 4.	B-cell lymphoma 6 protein-like.	0.516
Ctla4	Foxp3	G3GYW4	G3HNB1	Cytotoxic T-lymphocyte protein 4.	Forkhead box protein P3.	0.920
Ctla4	I79_001405	G3GYW4	G3GUN8	Cytotoxic T-lymphocyte protein 4.	Lymphocyte activation gene 3 protein.	0.775
Ctla4	I79_005129	G3GYW4	G3H4C8	Cytotoxic T-lymphocyte protein 4.	Tyrosine-protein kinase JAK3.	0.418
Ctla4	IL2	G3GYW4	G3HTL8	Cytotoxic T-lymphocyte protein 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.891
Ctla4	Jak3	G3GYW4	G3H4C9	Cytotoxic T-lymphocyte protein 4.	Tyrosine-protein kinase JAK3.	0.520
Ctla4	Socs5	G3GYW4	G3I8M9	Cytotoxic T-lymphocyte protein 4.	Suppressor of cytokine signaling 5.	0.506
Ctla4	Tbx21	G3GYW4	G3H5U9	Cytotoxic T-lymphocyte protein 4.	T-box transcription factor TBX21.	0.524
Ctla4	Tnfsf4	G3GYW4	G3GZK7	Cytotoxic T-lymphocyte protein 4.	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family.	0.483
Foxp3	Bcl6	G3HNB1	G3GT91	Forkhead box protein P3.	B-cell lymphoma 6 protein-like.	0.763
Foxp3	Ctla4	G3HNB1	G3GYW4	Forkhead box protein P3.	Cytotoxic T-lymphocyte protein 4.	0.920
Foxp3	I79_001405	G3HNB1	G3GUN8	Forkhead box protein P3.	Lymphocyte activation gene 3 protein.	0.496
Foxp3	IL2	G3HNB1	G3HTL8	Forkhead box protein P3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.947
Foxp3	Rag2	G3HNB1	G3GZ06	Forkhead box protein P3.	V(D)J recombination-activating protein 2.	0.466
Foxp3	Runx1	G3HNB1	G3HNW1	Forkhead box protein P3.	Runt-related transcription factor 1.	0.977
Foxp3	Runx3	G3HNB1	G3HMU5	Forkhead box protein P3.	Runt-related transcription factor 3.	0.559