(82 nodes) Positive regulation of T cell differentiation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	Rhoh	Rho-related GTP-binding protein RhoH. (191 aa)
	Il36b	Interleukin-1. (138 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	Dusp10	Dual specificity protein phosphatase 10. (482 aa)
	Hlx	H2.0-like homeobox protein. (374 aa)
	Bcl6	B-cell lymphoma 6 protein-like. (707 aa)
	I79_001513	Early growth response protein 3. (333 aa)
	Tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	I79_001990	Myb proto-oncogene protein. (650 aa)
	Socs1	Suppressor of cytokine signaling 1. (93 aa)
	Foxo3	Forkhead box protein O3. (672 aa)
	I79_002696	Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
	Mdk	Midkine. (160 aa)
	Ambra1	Activating molecule in BECN1-regulated autophagy protein 1. (1300 aa)
	Tnfsf4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
	Cd83	CD83 antigen. (202 aa)
	I79_004087	Tyrosine-protein kinase. (593 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Ap3b1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1091 aa)
	Zbtb1	Zinc finger and BTB domain-containing protein 1. (713 aa)
	I79_005603	Putative ubiquitin carboxyl-terminal hydrolase CYLD. (730 aa)
	Il1rl2	Interleukin-1 receptor-like 2. (190 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Shb	SH2 domain-containing adapter protein B. (298 aa)
	Lck	Proto-oncogene tyrosine-protein kinase LCK. (158 aa)
	I79_007699	GTPase IMAP family member 5. (344 aa)
	Pck1	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
	Zbtb7b	Zinc finger and BTB domain-containing protein 7B. (543 aa)
	Tnfsf9	Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (307 aa)
	Ap3d1	AP-3 complex subunit delta-1. (1199 aa)
	I79_010003	Zinc finger MIZ domain-containing protein 1. (960 aa)
	Rasgrp1	RAS guanyl-releasing protein 1. (787 aa)
	Syk	Tyrosine-protein kinase. (611 aa)
	I79_011181	Interleukin-7 receptor subunit alpha. (257 aa)
	I79_011202	T-cell surface glycoprotein CD1d1. (111 aa)
	Ada	Adenosine deaminase. (363 aa)
	I79_011711	Signal transducer and activator of transcription 5B. (274 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	Runx3	Runt-related transcription factor 3. (299 aa)
	Ccl19	C-C motif chemokine. (117 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	I79_012384	Leukocyte common antigen. (962 aa)
	Runx1	Runt-related transcription factor 1. (462 aa)
	Xbp1	X-box binding protein 1 isoform 1. (330 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	Nfkbid	NF-kappa-B inhibitor delta. (74 aa)
	I79_013013	Transcription factor SOX-13. (600 aa)
	I79_013182	Class II histocompatibility antigen, M alpha chain; Belongs to the MHC class II family. (261 aa)
	I79_013190	Ig-like domain-containing protein; Belongs to the MHC class II family. (206 aa)
	Il23a	Interleukin-23 subunit alpha. (196 aa)
	Cd74	H-2 class II histocompatibility antigen gamma chain. (329 aa)
	Nfkbiz	NF-kappa-B inhibitor zeta. (410 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Itpkb	Kinase; Belongs to the inositol phosphokinase (IPK) family. (789 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	I79_015109	Interleukin-6. (174 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	I79_016534	Leucine-rich repeat-containing protein 16C. (1178 aa)
	Tespa1	Uncharacterized protein KIAA0748-like. (496 aa)
	I79_017397	Protein kinase C zeta type. (280 aa)
	I79_017398	Protein kinase C zeta type. (53 aa)
	Vsir	Platelet receptor Gi24. (271 aa)
	Zbtb16	Zinc finger and BTB domain-containing protein 16. (423 aa)
	I79_017450	Zinc finger and BTB domain-containing protein 16. (236 aa)
	Sart1	U4/U6.U5 tri-snRNP-associated protein 1. (1215 aa)
	I79_017833	Lymphoid enhancer-binding factor 1. (276 aa)
	Il4r	Interleukin-4 receptor alpha chain. (835 aa)
	Anxa1	Annexin. (346 aa)
	I79_018785	Retinoic acid receptor alpha. (484 aa)
	I79_019038	Nck-associated protein 1-like. (1065 aa)
	Wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	Il4i1	L-amino-acid oxidase. (413 aa)
	I79_019300	L-amino-acid oxidase. (112 aa)
	Vnn1	Pantetheinase. (512 aa)
	CUNHXorf65	Cytokine receptor common gamma chain. (456 aa)
	Socs5	Suppressor of cytokine signaling 5. (530 aa)
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Adam8	Disintegrin and metalloproteinase domain-containing protein 8. (936 aa)
	Cd46	Membrane cofactor protein. (280 aa)
	I79_024694	Ig-like domain-containing protein; Belongs to the MHC class II family. (208 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ada	IL2	G3HLR7	G3HTL8	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.584
Ap3b1	Ap3d1	G3H316	G3HFA8	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit delta-1.	0.996
Ap3d1	Ap3b1	G3HFA8	G3H316	AP-3 complex subunit delta-1.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.996
Bcl6	Foxp3	G3GT91	G3HNB1	B-cell lymphoma 6 protein-like.	Forkhead box protein P3.	0.763
Bcl6	Gata3	G3GT91	G3GR59	B-cell lymphoma 6 protein-like.	Trans-acting T-cell-specific transcription factor GATA-3.	0.454
Bcl6	IL2	G3GT91	G3HTL8	B-cell lymphoma 6 protein-like.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.428
Bcl6	Rhoh	G3GT91	G3ILY9	B-cell lymphoma 6 protein-like.	Rho-related GTP-binding protein RhoH.	0.494
Bcl6	Xbp1	G3GT91	G3HNZ9	B-cell lymphoma 6 protein-like.	X-box binding protein 1 isoform 1.	0.475
CUNHXorf65	I79_004087	G3I7K3	G3H1Q5	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.419
CUNHXorf65	I79_011181	G3I7K3	G3HKG1	Cytokine receptor common gamma chain.	Interleukin-7 receptor subunit alpha.	0.850
CUNHXorf65	I79_011711	G3I7K3	G3HLW7	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription 5B.	0.464
CUNHXorf65	I79_011712	G3I7K3	G3HLW8	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription.	0.464
CUNHXorf65	I79_012384	G3I7K3	G3HNP2	Cytokine receptor common gamma chain.	Leukocyte common antigen.	0.592
CUNHXorf65	I79_015109	G3I7K3	G3HVW6	Cytokine receptor common gamma chain.	Interleukin-6.	0.414
CUNHXorf65	IL2	G3I7K3	G3HTL8	Cytokine receptor common gamma chain.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.958
CUNHXorf65	Il4r	G3I7K3	G3I4F2	Cytokine receptor common gamma chain.	Interleukin-4 receptor alpha chain.	0.760
CUNHXorf65	Syk	G3I7K3	G3HIA4	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.427
Ccl19	CgPICR_014700	G3HN20	G3HWU4	C-C motif chemokine.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.892
Ccl19	I79_012384	G3HN20	G3HNP2	C-C motif chemokine.	Leukocyte common antigen.	0.455
Cd46	Lck	G3ID99	G3H943	Membrane cofactor protein.	Proto-oncogene tyrosine-protein kinase LCK.	0.405